Pulsatile blood flow in a resistance vessel

The quasi-one-dimensional Newtonian fluid flow in an active vessel in which the inlet pressure oscillates about a mean value is considered. The vascular wall is assumed to display the Bayliss effect and a reaction to changes in blood flow. The first is characterized by the dependence of the contractility of the vascular smooth-muscle cells on the intravascular pressure and the second by the sensitivity of the endothelial cells to the wall shear stress. The dependence of the period-average radius and blood flow rate on the mean value and pulsation amplitude and frequency of the inlet pressure is investigated numerically. The characteristics are compared for the passive vessel, the vessel with the Bayliss effect, and the vessel with both reactions.     

Role of response to changes in flow rate in the regulation of vessel radius and blood flow

Estimates are presented for the effect of susceptibility of the inner surface of the blood vessel wall to shear stress on changes in diameter and volume blood flow rate. The model of thin-walled vessel with radius controlled by two parameters is used. The effect of rheological factors, hematocrit, and oxygen content in blood on the value of vessel response to a change in shear stress is considered. The estimates showed that the contribution of the vessel response in question to a change in blood volume flow rate amounts tens per cent. The influence of rheological (Fahraeus and Fahraeus-Lindqvist) effects on flow rate lies within several per cent. The role of the vessel response considered increases with anaemia: at low hematocrit its contribution to increase in flow rate exceeds 10%. Variation of oxygen concentration within the normal range has almost no effect on the hemodynamic parameters. With hypoxia, on the contrary, the participation of this response on changes in flow rate weakens: in severe hypoxia decrease in blood flow rate owing to a change in oxygen concentration equals approximately 9%.     

局部扩张动脉管血液振荡流的切应力分布

本文求解局部缓慢扩张动脉管中血液振荡流的基本方程，得到血管内血液的流速与压力梯度的关系。通过导出压力梯度沿局部扩张管轴向的变化特性。建立利用扩张段上游血管均匀段中心流速波形确定局部扩张管中血液流的速度和切应力分布的方法，文章以人体颈动脉余弦扩张为例进行分析。详细讨论了局部扩张对血管壁切应力及其梯度分布的影响。数值结果表明，在与刚性均匀管中管壁切应力沿轴向保持不变不同，在局部扩张段，管壁切应力将随着血管半径的增大而减小，因而管壁切应力梯度一般不为零，甚至在某些位置达到相当大的数值。另外，随着血管扩张程度的增加，管壁切应力还将进一步减小，而且管壁切应力梯度也将进一步增大，血管扩张导致管壁切应力的这些变化将直接影响血管壁的结构和功能，使其产生适应性的变化。     

脑Willis环的一维血流动力学及氧输运特性的数值研究

Willis环是大脑侧枝循环的重要组成部分, 研究其血流动力学特性以及氧输运规律对脑缺血疾病的认知和预防有着非常重要的作用. 该文旨在利用一维血流动力学模型模拟整个Willis环的流量变化和压力分布, 并建立动脉内氧输运的一维模型以模拟Willis 环内氧分压的变化规律, 为研究脑组织内血液流动和氧输运打下基础. 首先, 基于弹性圆管内的一维非线性流动方程和状态方程建立血流动力学模型, 在一维对流扩散方程的基础上, 考虑由管腔向壁面的扩散和壁面细胞的新陈代谢消耗推导出氧输运特性方程. 通过 Lax-Wendroff两步法对血流动力学方程进行离散, 而在进行对流扩散方程的离散时, 则运用迎风格式. 通过数值计算得到了正常情况下Willis环各个血管任意位置的流量、压力和氧分压的变化曲线, 正常情况下各个位置的氧分压处于稳定的平衡状态. 最后, 还通过此模型进一步模拟了右侧颈内动脉狭窄对各个血管内流动的影响. 当狭窄程度达到80%时, 中脑动脉的流量和压力会明显下降, 造成其供应区域的血流减少. 同时, Willis环右侧血管内的氧分压会大大降低, 而左侧血管的氧分压会出现上升趋势, 但幅度要小于右侧血管降低的幅度.     

A Model of Arterial Adaptation to Alterations in Blood Flow

Mechanisms of arterial adaptation to changes in blood flow rates were tested by comparing the predictions of a proposed theoretical model with available experimental data. The artery was modeled as an elastic membrane made of a nonlinear, incompressible, elastic material. Stimulation of the vascular smooth muscle was modeled through the generation of an active component of circumferential stress. The muscular tone was modulated by flow-induced shear stress sensed by the arterial endothelium, and is responsible for the vasomotor adjustment of the deformed arterial diameter in response to changes in blood flow. This study addresses the hypothesis that the synthetic and proliferative activity of smooth muscle cells, leading to a change in arterial dimensions, is shear stress dependent and is associated with changes in the contractile state of the smooth muscle cells and changes in the circumferential wall stress. Remodeling to a step change in flow was formulated as an initial-value problem for a system of first order autonomous differential equations for the evolution of muscular tone and evolution of arterial geometry. The governing equations were solved numerically for model parameters identified from experimental data available in the literature. The model predictions for the time variation of the geometrical dimensions and their asymptotic values were found to be in qualitative agreement with available experimental data. Experiments for validating the introduced hypotheses and further generalizations of the model were discussed. This revised version was published online in July 2006 with corrections to the Cover Date.     

A comparative study of poiseuille flow of a polar fluid under various boundary conditions with applications to blood flow

In this paper, Poiseuille flow of a polar fluid (model of a red blood cell suspension) under various boundary conditions at the wall, viz., slip or no-slip in the axial velocity and couple stresses zero or non-zero at the boundary, is considered from the point of view of its applications to blood flow. Analytic expressions for axial and rotational velocities, flow rate, effective viscosity and stresses are obtained. The magnitudes of the length ratioL and the coupling number N are determined in accordance with concentration and tube radius (in the existing literature, values ofL andN are chosen arbitrarily). Velocity profiles (both axial and rotational) and the variation of the effective viscosity with concentration, tube radius and for various values of the boundary condition parameters are shown graphically. The analytic results obtained are compared with experimental results (for blood flow). It is found that they are in a reasonably good agreement. The effective viscosity exhibits the Inverse Fahraeus-Lindquist Effect in all the cases (including the slip or no-slip in the velocity fields). A method is given for determining the non-zero couple stress boundary condition for a given concentration. Applications of this theory to blood flow are briefly discussed.     

Wave motions in viscoelastic tubes. Forced oscillations

A characteristic of small blood and lymphatic vessels is the capacity of the wall to change its rheological properties and lumen by active contraction of the annular muscle cells contained in it [1–3]. A model of flow in the vessels taking this feature into account has been proposed in [4, 5], where a linear stability analysis is also given. A consequence of wall activity is the existence of auto-oscillatory flow conditions [6–8], which have also been discovered in the numerical solutions of the corresponding problems [9, 10]. Up to the present time flows have only been studied under steady conditions at the ends of the vessel and in the environment. The wall of an actual blood vessel is subject to various actions, frequently of a periodic nature: pressure pulsations at entry and rhythmically changing external forces applied from the surrounding tissues. Data exist on the sensitivity of vessels to transient actions [11–13], in particular on the relationship of their hydraulic resistance to frequency and amplitude of the action. There has been frequent discussion of the hypothesis that bv contraction of muscles in its walls or by external compression the vessel can act as a valveless pump [14, 15]. Within the framework of the quasione-dimensional approximation given below [4] the movement of liquid along a viscoelastic tube in the presence of small amplitude periodic external actions has been studied. A general solution of the problem has been constructed and concrete examples are given illustrating the features of forced wave motions in a tube having passive and active properties.Translated from Izvestiya Akademii Nauk SSSR, Mekhanika Zhidkosti i Gaza, No, 4, pp. 94–99, July–August, 1984.     

Blood flow and microgravity

The absence of gravity during space flight can alter cardio-vascular functions partially due to reduced physical activity. This affects the overall hemodynamics, and in particular the level of shear stresses to which blood vessels are submitted. Long-term exposure to space environment is thus susceptible to induce vascular remodeling through a mechanotransduction cascade that couples vessel shape and function with the mechanical cues exerted by the circulating cells on the vessel walls. Central to such processes, the glycocalyx – i.e. the micron-thick layer of biomacromolecules that lines the lumen of blood vessels and is directly exposed to blood flow – is a major actor in the regulation of biochemical and mechanical interactions. We discuss in this article several experiments performed under microgravity, such as the determination of lift force and collective motion in blood flow, and some preliminary results obtained in artificial microfluidic circuits functionalized with endothelium that offer interesting perspectives for the study of the interactions between blood and endothelium in healthy condition as well as by mimicking the degradation of glycocalyx caused by long space missions. A direct comparison between experiments and simulations is discussed.     

Response of blood flow through an artery under stenotic conditions

This paper presents an analytical study on the behavoiur of blood flow in an artery having a stenosis. This is basically formulated through the use of a suitable mathematical model. The arterial segment under consideration is simulated by an anisotropically elastic cylindrical tube filled with a viscous incompressible fluid representing blood. The analysis is carried out for an artery with mild local narrowing in its lumen forming a stenosis. Particular emphasis has been paid to the effect of the surrounding connective tissues on the motion of the arterial wall. Blood is treated as a Newtonian fluid. The analysis is restricted to propagation of small amplitude harmonic waves, generated due to the flow of blood whose wave length is large compared to the radius of the arterial segment. The effect of the shape of stenosis on the resistance to blood flow has been well illustrated quantitatively through numerical computations of the resulting expressions. A quantitative analysis is also made for the variation of the phase velocity, as well as the velocity of wave propagation and the flow rate, in order to illustrate the applicability of the model.     

Effect of swirling flow on platelet concentration distribution in small-caliber artificial grafts and end-to-end anastomoses

Platelet concentration near the blood vessel wall is one of the major factors in the adhesion of platelets to the wall.In our previous studies,it was found that swirling flows could suppress platelet adhesion in small-caliber artificial grafts and end-to-end anastomoses.In order to better understand the beneficial effect of the swirling flow,we numerically analyzed the near-wall concentration distribution of platelets in a straight tube and a sudden tubular expansion tube under both swirling flow and normal flow conditions.The numerical models were created based on our previous experimental studies.The simulation results revealed that when compared with the normal flow,the swirling flow could significantly reduce the near-wall concentration of platelets in both the straight tube and the expansion tube.The present numerical study therefore indicates that the reduction in platelet adhesion under swirling flow conditions in small-caliber arterial grafts,or in end-to-end anastomoses as observed in our previous experimental study,was possibly through a mechanism of platelet transport,in which the swirling flow reduced the near-wall concentration of platelets.     

受支架支撑的血管管壁变形及应力分析

摘要：为了计算动脉粥样硬化和局部斑块形成的堵塞对血管壁工作状态的影响,本文根据血液流动的连续性方程、运动方程及管壁运动方程,在给定了血压波形函数的基础上,求得了狭窄血管管壁的径向位移及环向应力。分析了不同狭窄程度对血管壁变形及应力的影响;给出了不同狭窄情况下及局部斑块硬化程度不同时,血管植入支架所需的作用力。从而计算出了植入支架后血管壁的径向位移及应力状态。本文的研究结果可供临床上对狭窄血管植入支架后的变形与受力分析,和支架的正确安放参考,可避免发生堵塞严重或血管过渡硬化时,由于安放支架不当而使发生血管破裂的医疗事故。     

THE COUPLE MOTION BETWEEN VESSEL WALL AN DBLOOD IN THE ENTRANCE REGION OF A TAPERED VESSEL

ＴＨＥＣＯＵＰＬＥＭＯＴＩＯＮＢＥＴＷＥＥＮＶＥＳＳＥＬＷＡＬＬＡＮＤＢＬＯＯＤＩＮＴＨＥＥＮＴＲＡＮＣＥＲＥＧＩＯＮＯＦＡＴＡＰＥＲＥＤＶＥＳＳＥＬＣｅｎＲｅｎ－ｊｉｎｇ（岑人经）ＱｉｎＣｈａｎ（秦婵）ＴａｎＺｈｅ－ｄｏｎｇ（谭哲东）（ＳｏｕｔｈＣ...     

Pulsatile flow of Herschel-Bulkley fluid through stenosed arteries—A mathematical model

In this paper, the pulsatile flow of blood through stenosed artery is studied. The effects of pulsatility, stenosis and non-Newtonian behavior of blood, assuming the blood to be represented by Herschel-Bulkley fluid, are simultaneously considered. A perturbation method is used to analyze the flow assuming the thickness of plug core region to be non-uniform changing with axial distance. An expression for the variation of plug core radius with time and axial distance is obtained. The variation of pressure gradient with steady flow rate is given. Also the variation of wall shear stress distribution as well as resistance to flow with axial distance for different values of time and for different values of yield stress is given and the results analyzed.     

一种骨小管中液体流动产生的流量及切应力模型

骨组织受力变形后其内部液体就会流动,同时在其微观结构——骨单元壁中扩散,并进一步产生一系列与骨液流动相关的物理效应,如流体剪切应力、流动电位等,这些物理效应被细胞感知并做出破骨或成骨等反应,来使骨适应外部载荷环境.鉴于骨组织产生的内部液体流动很难实验测定,理论模拟是目前的主要研究手段.基于骨单元的多孔弹性性质建立了骨小管内部液体的流动模型,该模型将骨单元所受的外部载荷与骨小管内部液体的压力、流速、流量和切应力联系起来,并进一步可以研究其力传导与力电传导机制.骨小管模型的建立分别基于中空和考虑哈弗液体的骨单元模型,并考虑了骨单元外壁的弹性约束和刚性位移约束两种边界条件.最终得到骨单元在外部轴向载荷作用下,骨小管内部液体的流量及流体切应力的解析解.结果表明:骨小管中的液体流量与流体切应力都正比于应变载荷幅值和频率,并由载荷的应变率决定.因此应变率可以作为控制流量和流体切应力的一种生理载荷因素.流量随着骨小管半径的增大而非线性增大,而流体切应力则随着骨小管半径的增大而线性增大.此外,在相同的载荷下,含哈弗液体的骨单元的模型中,骨小管中液体的流量和切应力均大于中空骨单元模型.     

Numerical study of flow and heat transfer during oscillatory blood flow in diseased arteries in presence of magnetic fields

A problem motivated by the investigation of the heat and mass transfer in the unsteady magnetohydrodynamic(MHD) flow of blood through a vessel is solved numerically when the lumen of the vessel has turned into the porous structure.The time-dependent permeability and the oscillatory suction velocity are considered.The computational results are presented graphically for the velocity,the temperature,and the concentration fields for various values of skin friction coefficients,Nusselt numbers,and Sherwood numbers.The study reveals that the flow is appreciably influenced by the presence of a magnetic field and also by the value of the Grashof number.     

The blood flow and the motion of vessel wall

The correlation problem between the blood flow and the motion of vessel wall in the mammalian circulatory system is discussed in this paper. Supposing the blood flow is under the stable oscillatory condition, a set of formulas for velocity distribution, pressure distribution, displacement of vessel wall and constraining stress are obtained. Kuchar’s formulas are extended from steady flow to unsteady oscillatory flow by means of the formulas obtained in this paper. The problem of elasticity effect of vessel wall is also discussed.     

Steady flow through a slender tapered vessel with a partially permeable wall and closed end

We study the flow of a viscous fluid through a slender tapered tube whose radius may reduce to zero. The vessel is closed at the end, so that the flow is made possible owing to the fact that a portion of the tube wall is permeable. The smallness of the tube aspect ratio is exploited using an upscaling technique leading to a degenerate differential equation for pressure. Solutions are found either in explicit form or as power series expansions. This class of flows may represent, though in a largely approximated way, the blood flow though a coronary artery.     

Numerical simulation of mass transfer to micropolar fluid flow past a stenosed artery

A mathematical model of unsteady non‐Newtonian blood flow together with the mass transfer through constricted arteries has been developed. The mass transport refers to the movement of atherogenic molecules, i.e. blood‐borne components, such as low‐density lipoproteins from flowing blood into the arterial walls or vice versa. The flowing blood is represented as the suspension of all erythrocytes assumed to be Eringen's micropolar fluid and the arterial wall is considered to be rigid having cosine‐shaped stenosis in its lumen. The mass transfer to blood is controlled by the convection–diffusion equation. The governing equations of motion accompanied by the appropriate choice of the boundary conditions are solved numerically by Marker and Cell method and the results obtained are checked for numerical stability with the desired degree of accuracy. The quantitative analysis carried out finally includes the respective profiles of the flow‐field and the mass concentration along with their distributions over the entire arterial segment as well. The key factors, such as the wall shear stress and Sherwood number, are also examined for further quantitative insight into the flow and the mass transport phenomena through arterial stenosis. The present results show consistency with several existing results in the literature which substantiate sufficiently to validate the applicability of the model under consideration. Copyright © 2010 John Wiley & Sons, Ltd.     

Wave propagation in an elastic tube: a numerical study

In this paper, a fluid–wall interaction model, called the elastic tube model, is introduced to investigate wave propagation in an elastic tube and the effects of different parameters. The unsteady flow was assumed to be laminar, Newtonian and incompressible, and the vessel wall to be linear-elastic, isotropic and incompressible. A fluid–wall interaction scheme is constructed using a finite element method. The results demonstrate that the elastic tube plays an important role in wave propagation. It is shown that there is a time delay between the velocity waveforms at two different locations and that the peak velocity increases while the low velocity decreases in the elastic tube model, contrary to the rigid tube model where velocity waveforms overlap each other. Compared with the elastic tube model, the increase of the wall thickness makes wave propagation faster and the time delay cannot be observed clearly, however, the velocity amplitude is reduced slightly due to the decrease of the internal radius. The fluid–wall interaction model simulates wave propagation successfully and can be extended to study other mechanical properties considering complicated geometrical and material factors.     

Flowfields in lateral aneurysm models arising from parent vessels with different curvatures using PTV

 Pulsatile and steady flowfields in a lateral aneurysm model arising from the parent vessel with radius of curvature to vessel diameter ratios of 2.5, 5, and ∞ are presented in terms of particle tracking velocimetry (PTV) measurements and flow visualization. The steady-flow case has a Reynolds number of 600 and the pulsatile-flow one has a Womersley number of 3.9 and Reynolds number of 600. It is found that there exist two opposite vortices and a single vortex in the aneurysms arising from a straight and a curved parent vessel, respectively. The intra-aneurysmal flow velocity, vorticity, and wall shear stresses increase with increasing curvature of the parent vessel. It is suggested from the present results that the lateral aneurysm arising from a straight or small-curvature parent vessel has a tendency to thrombosis whereas the lateral aneurysm arising from a large-curvature parent vessel is more risky. Received: 14 August 1996/Accepted: 17 January 1997