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1.
以高藜芦胺为起始原料,经N-磺酰化反应制得高藜芦磺酰胺(2);2分别与芳乙烯甲醚经对甲苯磺酸催化的Pictet-Spengler反应后用金属钠脱除Ts基团合成了(±)-norlaudanosine(5a)和(±)-O,O-dimethylcoclaurine(5b);使用半量拆分法,以N-乙酰-L-苯丙氨酸为拆分剂,制得(S)-(-)-5a和(S)-(-)-5b,其结构经1H NMR,13C NMR,IR,MS和HR-ESI-MS确证。 相似文献
2.
以手性四氢吡咯片段3a和3b为起始原料, 采用汇聚式合成策略, 完成氮杂Solamin类似物(threo-trans-erythro)的两个对应的光学异构体2a(15S,16S, 19S,20R, 34S)和2b(15R,16R,19R,20S, 34S)的不对称合成. 化合物的结构以及四氢吡咯片段的立体构型均通过NMR波谱解析的方法得到确证. 这两个非对映异构体具有相近的体外抗肿瘤活性. 相似文献
3.
Introduction1,4 Diazabicyclo[2 .2 .2 ]octane (DABCO)wasre portedtocatalyzeorganicreactionsduetoitsstrongbasici ty .1,2 Severalchiraltrans 2 ,3 disubstitutedDABCOshavebeensynthesizedandappliedtotheasymmetricBaylis Hillmanreaction3andvicinalhydroxylation .4ThefirstsynthesisofthetitlecompoundwasreportedbySoai5from (2S ,5S) bis(phenylmethyl)piperazine (1) ,asshowninScheme 1.Butthisprocedureislengthy ,andtheoverallyieldisnotsosatisfactory .Besides ,thereport edmethodforthepreparationof 1is… 相似文献
4.
A series of chiral vicinal tertiary diacylamides with C 2‐symmetry was synthesized from (S)‐α‐phenylethylamine, different aromatic aldehydes, and oxalyl chloride. The diacylamides obtained were then reduced to afford chiral vicinal diamines with C 2‐symmetry. We propose that the diacylamides existed in four stable conformational isomers in solution because of the dihedral angle between acylamide bonds. 相似文献
5.
In this review are classified and analyzed structural parameters of almost 90 monomeric organoplatinum complexes with inner coordination spheres consisting of PtPCOX (X?=?N, Cl, S), PtPCNX (X?=?Cl, S, Br, I, As) and PtPCClX (X?=?S, I, As). These complexes crystallized in three crystal systems: orthorhombic (× 11), triclinic (× 32) and monoclinic (× 45). Distorted square planar arrangements about the Pt(II) atoms are provided by mono-, heterobi- and heterotridentate donor ligands. The chelating ligands create a wide variety of four-, five- and six-membered metallocyclic rings and the effects of both steric and electronic factors influence the L–Pt–L bite angles. There are wide variations in the trans-positions of the donor ligands. Two examples are classified as distortion isomers. 相似文献
6.
Yi Bo ZHOU Jun An MA Li Xin WANG Qi Lin ZHOU* State Key Laboratoratory Institute of Elemento-Organic Chemistry Nankai University Tianjin 《中国化学快报》2002,13(10)
During the last decade, 1-aminocyclopropanecarboxylic acid and its derivatives (ACCS) have attracted increasing attention of organic and bioorganic chemists due to their outstanding biological properties, ranging from antimicrobial, insecticidal, plant growth and fruit ripening controls, etc.1. Moreover, the three-membered carbocycle provides building blocks of unprecedented synthetic potential because it undergoes selective ring opening, ring enlargement or cycloaddition reactions2. The mo… 相似文献
7.
The optically active cobalt(III) complex with chiral cyclen, (2S,5S,8S,11S)-2,5,8,11-tetraethyl-1,4,7,10-tetraazacyclododecane, preferentially binds to D-phenylglycine (D-Phg) or D-t-leucine (D-t-Leu) rather than L-Phg or L-t-Leu, respectively, with 20% de in dimethyl sulfoxide at 293 K. Comparative studies on the crystal structures of cobalt(III) complexes with d-Phg and l-Phg revealed that the diastereoselectivity is due to the difference in the steric hindrance that should occur between the amino group of Phg and the ethyl group of cyclen. 相似文献
8.
[reaction: see text] A synthesis of (S,S)-isodityrosine 1, a naturally occurring, key structural subunit of numerous biologically active macromolecules, is described. A formal [3 + 2 + 1] cycloaddition (D?tz benzannulation) approach was utilized to simultaneously construct an aromatic ring and the diaryl ether linkage in one step. This key step was extended to the synthesis of (S,S)-isodityrosine in two separate convergent synthetic routes. This method demonstrates a novel and mild method for the synthesis of diaryl ethers. 相似文献
9.
Babievsky K. K. Davidovich Yu. A. Snegur L. V. Kochetkov K. A. 《Russian Chemical Bulletin》2019,68(10):1944-1945
Russian Chemical Bulletin - Betulonic acid S,S′-bis(carboxymethyl) dithioketal was obtained by condensation of betulonic and thioglycolic acids. 相似文献
10.
A series of novel dinuclear platinum(Ⅱ) complexes with (1S, 3S)-1,2,3,4-tetrahydroisoquinolines as the ligands were synthesized as potential anticancer agents in several steps starting from commercially available L-DOPA. The cytotoxicities of the series of dinuclear platinum(Ⅱ) complexes of tetrahydroisoquinoline were tested against HCT-8, BEL-7402, A2780, MCF-7, Hela, A549 and BGC-823 cell lines by the MTT test. These complexes showed selective inhibition activity against cisplatin-insensitive cell line Skov3. 相似文献
11.
Six new complexes, Mn(CO)(
5-C5H5){Ph2P(S)(CH2)
n
P(S)Ph2}] (1a–3a) [(1a), n=1; (2a), n=2; (3a), n=3] and [Mn2(CO)4(
5-C5H5)2(cis--Ph2P(S)(CH2)
n
P(S)Ph2)] (1b–3b) [(1b), n=1; (2b), n=2; (3b), n=3] have been synthesized by the photochemical reaction of [(
5-C5H5)Mn(CO)3] with Ph2P(S)(CH2)
n
P(S)Ph2 [n=1, dppm(S)2; 2, dppe(S)2; 3, dppp(S)2]. The complexes have been characterized by elemental analysis, mass spectroscopy, f.t.-i.r. and 31P–[1H]-n.m.r. spectroscopy. The spectroscopic studies reveal that coordination of the ligand iscis-chelate bidentate in [Mn(CO)(
5-C5H5){Ph2P(S)(CH2)
n
P(S)Ph2}] (1a–3a) and cis-bridging bidentate between two metals in [Mn2(CO)4(
5-C5H5)2(cis--Ph2P(S)(CH2)
n
P(S)Ph2)] (1b–3b). 相似文献
12.
Suk-Ku Kang Hyun-Sung Cho Hyeong-Su Sim Beon-Kyu Kim 《Journal of carbohydrate chemistry》2013,32(6):807-812
Abstract In connection with our projects on the synthesis of biologically active 5-hydroxyalkan-4-olides which have a chiral 2.3-diol unit,1 we have carried out the synthesis of (4R,5S)-(?)- and (4R,5S)-(+)-L-factors (1).2 the proposed autoregulators from Streptomyees griseus, and muricatacin (2),3 a biologically active constituent from the seeds of Annona muricata L. via 2.3-dihydroxy aldehydes derived from D-glucose. Hex-3-enofuranose4 was prepared by the elimination of thetriflate derived from D-glucose. 相似文献
13.
(R,S)-5-Ethyl-5-(2′-pentyl)barbituric acid (I)1,2 is metabolized in vivo to give all four possible optical isomers of 5-ethyl-5-(3′-hydroxy-1′-methylbutyl)barbituric acid (II). 3,4 From metabolism studies of pure (1′S)- I and (1′3)-I, Palmer and co-workers4,5 were able to determine the relative amounts of each of the four isomers formed. These studies showed that (1′S)-I gave mainly one enantiomer of (1′S)-II, whereas (1′R)-I gave approximately equal amounts of both (1′R)-II enantiomers. 相似文献
14.
《Journal of carbohydrate chemistry》2013,32(2-3):123-132
Abstract A general procedure for the synthesis of 1‐O‐acyl‐β‐D‐glucuronic acids using the benzyl 1-O-trichloroacetimidoyl-2,3,4-tri-O-benzyl-D-glucopyranuronate 6 as donor is exemplified by the synthesis of the urine metabolites of (S)‐naproxen, desmethyl (S)‐naproxen, indoprofen, and carboxymefloquine. The key intermediate benzyl 2,3,4‐tri‐O‐benzyl‐D‐glucopyranuronate 5 is easily accessible in four steps (29%) from the peracetylated β-D-glucuronic acid 1. 相似文献
15.
《Tetrahedron: Asymmetry》2000,11(22):4537-4541
Conformationally restricted metabotropic glutamate receptor agonist (2S,1′S,2′S)-2-(Carboxycyclopropyl) glycine (LCCG-I) 1 have been efficiently synthesized in a stereoselective manner. A convenient five step synthesis of 1 from readily available (−)-dimenthyl (1S,2S)-cyclopropane-1,2-dicarboxylate 5 in 49% overall yield is described. 相似文献
16.
Introduction Asarelativelynewmemberofnaturalalkaloidswith2 ,6 disubstituted 3 piperidinolskeleton ,irnigaine 1wasisolatedfromthetubersofArisarumVulgare (Araceae)in1995byMelhaouiandBode .1Itsstructureandrelativeconfigurationswereelucidatedby1HNMRstudiesandtheabsoluteconfigurationwasproposedonthebasisofitsopti calrotation .1Soonafterthen ,Meyerandhisco workersreportedthefirstsynthesisof (- ) (2R ,3R ,6S) irni gaineandtheconfigurationconfirmation .Althoughtheirsynthesisroutewasshortan… 相似文献
17.
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19.
《Journal of Coordination Chemistry》2012,65(1-2):115-123
Abstract Electronic absorption and CD spectra are reported for the sexidentate complexes, trans(O5)-Rh(EDDDA)?, trans(O5 O6)-Rh(EDDDA)?, and trans(O5)-Rh(S,S-EDDS)? (EDDDA)=ethylenediamine-N,N′-di-3-propionate; S,S-EDDS=(S,S)-ethylenediamine-N,N′-disuccinate). Because of the sterospecific coordination of the S,S-EDDS ligand the absolute configuration of (+)D-trans(O5)-Rh(S,S-EDDS)? is known to be Λ. By comparison of their CD spectra to that of the (+)D isomer of trans(O5)-Rh(S,S-EDDS)?, the absolute configurations of the (?)DEDDDA complexes are assigned tentatively. 相似文献
20.
Zdeněk Trávníček Richard Pastorek Zdeněk Šindelář Roman Klička Jaromír Marek 《Transition Metal Chemistry》1996,21(1):81-84
Summary The reaction of bis(iso-propylxanthato)nickel(II) with 1,2-bis(diphenylphosphino)ethane (dppe) in a 11 molar ratio affords [Ni(S2CO)(dppe)], which, on the basis of its magneto-chemical and spectral properties, has been characterized as a square-planar Ni complex. The complex was one-electron irreversibly oxidized at a potential of 0.673 V versus s.c.e. The crystal and molecular structure of a twinned crystal of the complex has been elucidated, and consists of two crystallographically independent molecules in which each Ni atom is coordinated by two S atoms from the dithiocarbonate ligand and two P atoms from the dppe ligand in an approximately square-planar arrangement. 相似文献