胃癌患者与非癌对照血清微量元素含量对比研究

在医院选择３３例经病理学诊断的胃癌患者及７９例非癌对照，测定其血清锌、铜、锰、钼、硒含量并进行对比分析。结果显示，胃癌患者血清铜含量显著低于对照组（Ｐ＜０．０５））；血清硒含量亦显著低于对照组（Ｐ＜０．００２）．曾报道，江西土壤有效钼含量与胃癌死亡率呈负相关．江西胃癌患者发钼含量显著低于非癌对照．硒是抗氧化剂和抗氧化酶的重要成分，在抑制自由基反应、清除过氧化物方面起重要作用．显然钼、硒与胃癌关系十分密切。缺乏钼、硒是造成胃癌发病率升高的危险因素。     

缺锌对大鼠所致危害的实验研究

用缺锌饲料饲养Wister大鼠,以N-甲基-N硝基-N亚硝基胍(MNNG)作为致癌剂染毒,观察了缺锌对大鼠的危害。结果显示,实验组动物血清锌降低,脱毛、吃毛,体质量减轻,免疫力下降,前胃黏膜增生,前胃癌发生率显著高于对照;2例实验组大鼠胃腺区发生非典型增生,对照组无此种现象。提示适量锌具有保护胃黏膜、抑制肿瘤发生的作用;缺锌是导致胃癌发生率升高的危险因素。     

非水反相高效液相色谱法同时检测人血清中VA,VD3,VE和β—胡萝卜素

介绍一种用非水反相高效液相色谱法及外标法同时检测人血清中的视黄醇（ＶＡ）、胆钙化醇（ＶＤ３）、α－生育酚）ＶＥ）和β－胡萝卜素含量的方法。此方法实际用于检测胃癌病例及对照血清标本１８８份，有操作简便，出限低的特点。     

126例脑血栓形成的危险因素分析

收集了１２６例脑血栓形成病例，分析了导致脑血栓形成的危险因素。     

胃液中微量元素含量测定及临床意义

采用原子吸收法测定了６０例受试者空腹胃液中Ｚｎ，Ｃｕ，Ｆｅ，Ｃａ的含量，以探讨微量元素与胃部疾病的关系，结果显示，Ｚｎ元素在萎缩性胃炎和胃癌组较对照明显升高，而在胃溃疡组则较为对照组明显降低；Ｃｕ元素在萎缩性胃炎和胃癌组较对照组明显升高，Ｆｅ，Ｃａ元素在病例组与对照组间未见差异，Ｚｎ／Ｃｕ比值在胃溃疡和胃癌组较对照组明显降低，本研究为开展微量元素与胃病关系的研究提供了有益资料。     

ICP-MS测定肾癌患者血清微量元素水平及其临床意义分析

采用电感耦合等离子体质谱法(ICP-MS)对24例健康对照者、30例肾癌患者血清中多种微量元素的含量进行测定,探讨血清微量元素与肾肿瘤的关系。与健康对照组相比,肾癌患者血清中V、Co、Ni、Mn、Cd的含量显著增高(P0.05),而Ca、Zn的含量明显降低(P0.05)。Co、Ni、Cd可能是肾癌的危险因素,Ca、Zn可能为肾癌的保护因素。V、Mn与肾癌的相关性仍需进一步研究。     

非水反相高效液相色谱法同时检测人血清中V_A、V_D_3、V_E和β－胡萝卜素

介绍一种用非水反相高效液相色谱法及外标法同时检测人血清中的视黄醇（Ｖ＿Ａ）、胆钙化醇（Ｖ＿Ｄ＿３）、α－生育酚（Ｖ＿Ｅ）和β－湖萝卜素含量的方法。此方法实际用于检测胃癌病例及对照血清标本１８８份,有操作简便、检出限低的特点。     

血清六种微量元素与胃癌的相关性

为研究胃癌患者血清微量元素与胃癌的相关性 ,探讨其在胃癌诊断中的应用 ,取甘肃省武威市 2 0例胃癌患者血清作为胃癌组 (C组 ) ,3 0例当地健康志愿者血清作为对照组 (N组 ) ,用电感耦合等离子体原子发射光谱仪 (ICP -AES)进行了 6种微量元素的测定 ,并将结果用SPSS软件作统计分析。结果表明 ,胃癌组血清微量元素值高于对照组的元素有Cu、Cu/Zn、Fe (P <0 0 1 ) :低于对照组的元素有Zn、Mn (P <0 0 5 )。经Logistic回归分析 ,进入方程的为Zn元素 (P<0 0 5 )。多种微量元素联合诊断胃癌的准确率为 87% ,误诊率为 8%。提示 ,甘肃省武威市胃癌患者血清中Cu、Cu/Zn、Fe的升高以及Zn、Mn的降低与胃癌的发生具有相关性。其中Zn与胃癌的发生关系最为密切 ,且Zn降低可能为胃癌发生的癌前因素。测定血清微量元素值可以作为早期诊断胃癌的一种工具。     

与年龄有关的Logistic回归理论及应用

本文发展了无条件和条件Ad-logistic回归模型理论,同时实现病例与对照,以及不同发病年龄之病例间的比较分析,所估计的复相对危险度和复归因危险度,包括了危险因素对于发病与否及发病早晚两方面的方差贡献,因而更为客观地评价了其在病因学和发病学中的作用。现有的logistic回归模型,只是本文方法在忽略病例发病年龄差异时的一种特例。为说明方法的应用,文中给出了食管癌和肺癌病例——对照研究的分析实例,并与现有logistic回归结果进行了比较。     

血清铜、铜/锌比值作为胃癌患者肿瘤标志物的应用价值

对１９８例胃癌患者同时检测的血清铜、锌及癌胚抗原（ＣＥＡ）结果进行了分析,发现联合应用血清铜、铜／锌比值及ＣＥＡ对判断胃癌患者有无肿瘤负荷有较高价值。     

Basal Cell Carcinoma: What’s New Under the Sun

Basal cell carcinoma (BCC) is the most common skin cancer in white populations with an increasing incidence worldwide, thereby imposing an important public health problem. Its etiology is still unclear, but existing data indicate that the risk for BCC development is of multifactorial origin and results from the interplay of both constitutional and environmental factors. Yet, UV radiation (UVR) is believed to be the predominant causative risk factor in the pathogenesis of BCC. For years, BCC and squamous cell carcinoma (SCC) have been grouped together as “nonmelanoma skin cancer.” However, it seems that there are considerable biologic differences between BCC and SCC, and thus each type of epithelial cancer should be addressed separately. The present review provides an overview of the intriguing etiologic link of BCC with UVR and attempts a comprehensive review of recent epidemiologic and molecular evidence that supports this association.     

桥本氏甲状腺炎合并甲状腺乳头状微小癌患者的超声特点与临床参数的相关性分析

本文探讨了桥本氏甲状腺炎合并甲状腺乳头状微小癌患者的超声特点与临床参数的相关性。选择2010年1月~2018年12月我院收治的桥本氏甲状腺炎合并甲状腺乳头状微小癌患者75例作为研究组,单纯桥本甲状腺炎患者696例作为对照组,分析了两组患者的临床病理特征、二维超声图像特征及内部血流图像特征。结果显示,两组平均年龄、肿块直径、病灶数量、甲状腺结构、形态、晕圈比较无统计学差异(P>0.05);研究组的性别构成、病灶钙化情况、内部回声情况、内部血流情况与对照组有统计学差异(P<0.05)。多因素Logistic回归分析显示,女性、微钙化、边缘回声不清晰、内部极低回声、内部无血流是桥本氏甲状腺炎合并甲状腺乳头状微小癌的危险因素(P<0.05)。说明超声能够对桥本氏甲状腺炎合并甲状腺乳头状微小癌进行有效诊断。     

Raman spectroscopic analysis of apoptosis of single human gastric cancer cells

A drug (5-FU) was employed to treat the gastric carcinoma cells and induce apoptosis of the cancer cells. Raman spectra obtained from single gastric carcinoma cells and the induced apoptotic cells through scan-excitation mode were used to analyze the effectiveness of the treatment. The major difference of the apoptotic cells from the cancer cells are the reduction in intensities of vibration bands generated by cellular lipids, proteins and nucleic acids. In particular, large intensity reduction in nucleic vibrations at 782, 1092, 1320, 1340, and 1578 cm⁻¹ was observed upon apoptosis of the gastric carcinoma cells. Up to 45% reduction in the magnitude of the 782 cm⁻¹ peak in Raman spectra of the apoptotic cells was observed, which suggests the breakdown of phosphodiester bonds and DNA bases. We showed that the principal components analysis (PCA), a multivariate statistical tool, can be used to distinguish single apoptotic cells and gastric carcinoma cells based on their Raman spectra.     

胃癌患者胃液的荧光研究

利用外加荧光物质在肿瘤部位的特征吸附,或通过恶性肿瘤的自体荧光进行临床诊断及治疗均有报道,但对外加或自体荧光物质的认识大都集中于卟啉类分子。我们在利用胃液对胃癌特征荧光物质的研究中,首次提出了黄素蛋白类为胃癌胃液的特征荧光物质及存在形式,为胃癌的临床诊断和治疗及癌变机理的阐明提供了新的依据。     

Basal and squamous cell carcinoma risks for golfers: an assessment of the influence of tee time for latitudes in the Northern and Southern hemispheres

This study investigates the influence of tee time to determine the relative basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) risk for weekly single round competition golfers located in the Northern and Southern latitude ranges between 25°, 35°, 45° and 55°. A comparative risk methodology, employing annual erythemally effective ultraviolet (UVE) exposure calculations was used to determine BCC and SCC risk factors for golfers using a regular weekly tee time. Relative risk was found to be proportional to golf tee time with mid morning tee times generally presenting the greatest risk in each latitude range. The greatest contribution toward the risk of developing basal and squamous cell carcinoma was found to occur for golfers beginning weekly rounds mid to late morning, with specific risk factors of 1.47 (BCC) and 1.98 (SCC) in the Northern hemisphere compared with similar maximum risk factors of 1.51 (BCC) and 2.08 (SCC) in the Southern hemisphere occurring at comparable morning tee times. Differences in annual UVE exposure between the golfer and non-golfer were the largest determinant of BCC and SCC risk. Generally, these risks were found to decrease with lower latitude although contribution toward overall risk was influenced strongly by the global time zone of each studied golf course site.     

Real-time Quantitative RT-PCR for CT9 Level in Human Cancer

Introduction Malignantdiseasesarecharacterizedbytheunreg ulatedgrowthoftransformedcells.Inrecentyears,dramaticinsightsintothemolecularmechanismsofthis phenomenonhavebeenachievedfrombasiccancerre search.Manycellularfunctionsareregulatedbychan gesingeneexpr…     

A modeling study of the oxidation of propionaldehyde in the negative temperature coefficient regime

A chemical kinetic reaction mechanism has been developed which describes the oxidation of propanal within the temperature range 400–700 K. This mechanism has been tested against data obtained by four experimental groups over a wide range of initial conditions. The induction period and the absolute rate of propanal consumption are predicted to within a factor of 2 for initial densities of oxygen and propanal ranging over factors of 400. The existence and location of the negative temperature coefficient in the consumption of propanal are also simulated properly. The yields of all major and most minor products are predicted to within a factor of 2 for the wide variety of initial conditions tested. Sensitivity analyses were carried out at 553 and 713 K to identify the reactions primarily responsible for controlling the rate of propanal consumption and the distribution of products.     

Presence of autocrine hepatocyte growth factor-Met signaling and its role in proliferation and migration of SNU-484 gastric cancer cell line

Autocrine stimulation via coexpression of hepatocyte growth factor (HGF) and its receptor (Met) has been reported in many human sarcomas, but few in carcinomas. In this report, we found that one gastric cancer cell line, SNU-484, among 11 gastric cell lines tested has an autocrine HGF- Met stimulation. RT-PCR, ELISA and scattering assay using MDCK cells revealed that SNU-484 cells secreted a significant amount of active HGF (about 1.25 +/- 0.41 ng/24 h/10(6) cells) into conditioned medium. Resultantly, Met in this cell line was constitutively phosphorylated. Neutralizing antibodies against HGF reduced the tyrosine phosphorylation of Met, resulting in the inhibition of cell proliferation and migration (P <0.005). To the best of our knowledge, this is the first report on autocrine HGF-Met signaling in a gastric cancer cell line. Our observations with SNU-484 cells suggest that HGF is involved in the development and/or progression of some gastric carcinoma through an autocrine mechanism.     

超声双重造影及MRI对胃癌诊断及术前T分期的对比研究

选取2017年8月~2019年2月我院收治的胃癌患者130例作为研究对象,依据患者病理诊断结果作为金标准,分析磁共振成像(magnetic resonance imaging,MRI)与超声双重造影对胃癌的诊断价值及术前T分期的价值。结果显示,超声双重造影共检出120例胃癌患者,出现10例漏诊,MRI共检出109例胃癌患者,出现21例漏诊。金标准共检出52例T1期、32例T2期、26例T3期、20例T4期患者,超声双重造影诊断出T1期48例,符合率92.31%;T2期30例,符合率93.75%;T3期24例,符合率92.31%;T4期18例,符合率90.00%,进一步分析显示,超声双重造影对不同胃癌T分期的诊断价值均高于MRI。因此,超声双重造影对胃癌的诊断价值及对术前T分期诊断价值均高于MRI。