共查询到20条相似文献,搜索用时 109 毫秒
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在所有的相衬成像方法中,X射线同轴轮廓成像由于光路简单、不需要任何光学元件而备受关注.其缺点是无法直接消除散射的影响,从而限制了它在生物医学等领域中的应用.利用数字模拟方法研究了引入散射前后轮廓像的质量随样品到探测器距离的变化情况.模拟结果表明直接轮廓成像存在一个最佳成像距离,因而无法通过改变样品到探测器距离来减小散射的影响.利用定量相衬成像不受成像距离限制的特点,研究了远距离成像时散射的影响.结果表明,样品到探测器的距离增大到一个临界值时,散射对重构像的影响可降到一个极值,此时成像质量得到了明显改善.
关键词:
散射
X射线同轴轮廓成像
定量相衬成像 相似文献
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基于 Zernike相衬成像原理和光瞳切趾原理,提出一种将相位板和切趾光子筛集成为一个相衬显微物镜的 X射线相衬成像光子筛的设计方法.这种 X射线相衬成像物镜可以实现生物体组织或者其他弱吸收材料的高分辨率和高衬度成像.通过优化光子筛透镜的衍射结构,可以抑制成像系统的点扩展函数的旁瓣和消除高阶衍射焦点,从而提高成像分辨率;另外,将光子筛透镜和变相板合为一体,克服了成像透镜和变相板难以对准的缺陷.以高斯切趾光子筛为例,实验验证了设计方法的可行性.
关键词:
X射线显微技术
相衬成像
光瞳切趾
光子筛 相似文献
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在临床实际应用中,X射线源是一个具有有限尺寸的多色光源.基于Fresnel-Kirchhoff衍射理论,考虑空间相干的影响,新的类同轴X射线相衬成像公式被导出.分别代表吸收效应与相位效应的吸收衬度传递函数和相位衬度传递函数从新公式得到.吸收衬度传递函数和相位衬度传递函数的曲线由Matlab给出,不同源半径的最佳成像位置也被计算.理论分析结果如下:1)当光源半径足够大时空间相干效应须被考虑,减小源半径可以增强相位效应|2)源半径与最佳成像位置间有确定关系,并在本文中给出|3)源尺寸效应对相位效应影响不是无限的|4)减小入射X射线光子能量将会显著增强相位效应,但不会对最佳成像位置有影响,因此,上述结论可以被拓展到多色光情况.为了验证理论结果,本文给出了对一个表面破损的光学玻璃微聚焦相衬成像的实验结果.其中一些实验结果与理论分析符合很好,但也有一些实验未达到预期,相关的解释文中也已给出. 相似文献
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YU Bin PENG Xiang TIAN Jindong NIU Hanben DIAO Luhong & LI Hua . Key Laboratory of Optoelectronic Devices Systems of Ministry of Education Institute of Optoelec- tronics Shenzhen University Shenzhen China . State Key Laboratory of Precision Measuring Technology Instruments Tianjin University Tianjin China . Key Laboratory of Intelligent Information Processing Institute of Computing Technology Chinese Academy of Sciences Beijing China 《中国科学G辑(英文版)》2005,48(4):450-458
X-ray phase contrast imaging (XPCI) is a novel method that exploits the phase shift for the incident X-ray to form an image. For light elements such as carbon, hydrogen and oxygen, the phase-shift term can be up to 1000 times greater than the absorption term in the hard X-ray energy region. So XPCI has attracted much attention in recent years. Various methods for XPCI have been proposed and demonstrated on synchrotron devices and other X-ray sources[1―13], particularly the in-line metho… 相似文献
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A variable-wavelength-based approach of phase retrieval for contrast transfer function based methods
Kashyap YS Agrawal A Sarkar PS Shukla M Roy T Sinha A 《Journal of synchrotron radiation》2010,17(6):799-803
X-ray phase-contrast imaging has emerged as an important method for improving contrast and sensitivity in the field of X-ray imaging. This increase in the sensitivity is attributed to the fact that, in the hard X-ray regime, the phase shift is more prominent as compared with the attenuation for materials having a low X-ray absorption coefficient. Among all the methods using the X-ray phase-contrast technique, in-line phase-contrast imaging scores over the other methods in terms of ease of implementation and efficient use of available X-ray flux. In order to retrieve the projected phase map of the object from the recorded intensity pattern, a large number of algorithms have been proposed. These algorithms generally use either the transport of intensity or contrast transfer function based approach for phase retrieval. In this paper it is proposed to use multiple wavelengths for phase retrieval using the contrast transfer function based formalism. 相似文献
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A new method for information retrieval in two-dimensional grating-based X-ray phase contrast imaging 下载免费PDF全文
Grating-based X-ray phase contrast imaging has been demonstrated to be an extremely powerful phase-sensitive imaging technique.By using two-dimensional(2D) gratings,the observable contrast is extended to two refraction directions.Recently,we have developed a novel reverse-projection(RP) method,which is capable of retrieving the object information efficiently with one-dimensional(1D) grating-based phase contrast imaging.In this contribution,we present its extension to the 2D grating-based X-ray phase contrast imaging,named the two-dimensional reverseprojection(2D-RP) method,for information retrieval.The method takes into account the nonlinear contributions of two refraction directions and allows the retrieval of the absorption,the horizontal and the vertical refraction images.The obtained information can be used for the reconstruction of the three-dimensional phase gradient field,and for an improved phase map retrieval and reconstruction.Numerical experiments are carried out,and the results confirm the validity of the 2D-RP method. 相似文献
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Most papers in the field of optical phase retrieval either consider only the intensity (or amplitude) profile of the object under inspection (or scatterer location in the X-ray version), or a uniform tilt/rotation of the object beam. However, phase retrieval is able to recover the phase profile of the object (beam) as well, which theoretically makes the observable interference of phase retrieved object waves possible. In this paper we demonstrate this principle experimentally on centimeter sized deformable reflective objects (as large as 40 mm by 40 mm) and corresponding simulations are also presented. When the CCD camera is moved along the optical axis in the Fresnel region, the interference fringes of the displacement field have low contrast. On the other hand, when an imaging setup is built, and the camera moves near the image plane, high fringe contrast can be obtained. These fringes however suffer from some phase error. In our work the iterative modulus projection algorithm was used as a simply implementable phase retrieval method. 相似文献
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Since the invention of Zernike phase contrast method in 1930,it has been widely used in optical microscopy and more recently in X-ray microscopy.Considering the image contrast is a mixture of absorption and phase information,we recently have proposed and demonstrated a method for quantitative phase retrieval in Zernike phase contrast X-ray microscopy.In this contribution,we analyze the performance of this method at different photon energies.Intensity images of PMMA samples are simulated at 2.5 keV and 6.2 keV,respectively,and phase retrieval is performed using the proposed method.The results demonstrate that the proposed phase retrieval method is applicable over a wide energy range.For weakly absorbing features,the optimal photon energy is 2.5 keV,from the point of view of image contrast and accuracy of phase retrieval.On the other hand,in the case of strong absorption objects,a higher photon energy is preferred to reduce the error of phase retrieval.These results can be used as guidelines to perform quantitative phase retrieval in Zernike phase contrast X-ray microscopy with the proposed method. 相似文献
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Heng Chen Zhili Wang Kun Gao Qiyue Hou Dajiang Wang Ziyu Wu 《Journal of synchrotron radiation》2015,22(4):1056-1061
In recent years, increasing attention has been devoted to X‐ray phase contrast imaging, since it can provide high‐contrast images by using phase variations. Among the different existing techniques, Zernike phase contrast microscopy is one of the most popular phase‐sensitive techniques for investigating the fine structure of the sample at high spatial resolution. In X‐ray Zernike phase contrast microscopy, the image contrast is indeed a mixture of absorption and phase contrast. Therefore, this technique just provides qualitative information on the object, which makes the interpretation of the image difficult. In this contribution, an approach is proposed for quantitative phase retrieval in X‐ray Zernike phase contrast microscopy. By shifting the phase of the direct light by π/2 and 3π/2, two images of the same object are measured successively. The phase information of the object can then be quantitatively retrieved by a proper combination of the measured images. Numerical experiments were carried out and the results confirmed the feasibility of the proposed method. It is expected that the proposed method will find widespread applications in biology, materials science and so on. 相似文献
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Based on the propagation X ray phase contrast imaging theory, a spatial domain constraint iterative phase retrieval method is described in detail. This algorithm limits the object spatial domain according to the actual sample size firstly, and modify the image plane data with the actual test data, then the iteration can be terminated until iteration precision or the number of iterations meet the preset requirements. Finally the numerical simulation is made to evaluate the rapid phase retrieval algorithm performance, and a real column fiber material experiment is carried out using a micro focus X ray phase contrast imaging experiment platform, the phase distribution image of the column fiber is calculated out by this algorithm. The results show that this phase retrieval algorithm is effective, and the method has a potential stability and accuracy for X ray phase contrast imaging technology. 相似文献
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We develop an element-specific x-ray microscopy method by using Zernike phase contrast imaging near absorption edges, where a real part of refractive index changes abruptly. In this method two phase contrast images are subtracted to obtain the target element: one is at the absorption edge of the target element and the other is near the absorption edge. The x-ray exposure required by this method is expected to be significantly lower than that of conventional absorption-based x-ray elemental imaging methods. Numerical calculations confirm the advantages of this highly efficient imaging method. 相似文献
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M. Kageyama S. Tasaki M. Hino T. Ebisawa D. Yamazaki H. Hayashida Y. Abe 《Physica B: Condensed Matter》2009,404(17):2615-2619
We present an imaging technique utilizing a neutron spin interferometer. Neutron spin phase contrast is achieved in spatial resolved measurements of the phase difference between two superposed neutron spin states introduced by passing through a magnetic sample. Since the phase difference of spin states parallel and anti-parallel to the magnetic field is proportional to the magnetic field integral, it is possible to record images of the internal magnetic field distribution of the sample. Taking advantage of high transmission probabilities, neutron spin phase contrast provides non-destructive images of internal magnetic structures. 相似文献