含2-三氟甲基苯并咪唑杂环化合物的合成

以2-三氟甲基苯并咪唑-1-乙酰肼为原料,在不同条件下合成了一系列新的1,3,4-(丰刀女)二唑啉及均三唑并噻二唑衍生物,所得化合物的结构经元素分析,IR,¹HNMR和MS确证,并对其波谱性质进行了讨论.     

Facile Synthesis of Some 3-(Benzimidazol-2-yl)- and 3,6-Di(Benzimidazol-2-yl)-9-ethyl-9H-carbazoles

A simple and efficient synthesis of novel 3-(benzimidazol-2-yl)- and 3,6-di(benzimidazol-2-yl)-9-ethyl-9H-carbazoles is described. The synthetic approach for the preparation of 2-substituted benzimidazoles 4–8 and bis-benzimidazoles 9–12 was achieved by the condensation of carbazole-3-carbaldehyde 2 and carbazole-3,6-dicarbaldehyde 3 with o-phenyldiamines in dimethylformamide or dimethylsulfoxide in moderate to excellent yield. The identities of synthesized compounds were confirmed using ¹H NMR, ¹³C NMR, infrared (IR), and high-resolution mass spectrometry (HRMS).     

Novel Aspects of the Reaction of 3-(Benzimidazol-2-yl)-2-iminocoumarins with Aromatic Aldehydes

The reaction of 3-(benzimidazol-2-yl)-2-iminocoumarins with aromatic aldehydes has been studied. The condensation products 7-aryl-7H-benzo[4,5]imidazo[1,2-c]benzopyrano[3,2-e]pyrimidines or 3-(benzimidazol-2-yl)coumarins are formed depending on the nature of the substituent in the starting 2-iminocoumarin and aldehyde. In DMF medium, 7-aryl-7H-benzo[4,5]imidazo[1,2-c]benzopyrano[3,2-e]pyrimidines isomerize to the corresponding 7-aryl-14H-benzo[4,5]imidazo[1,2-c]benzopyrano[3,2-e]pyrimidines. The effect of the substituent on the isomerization process has been studied and the reaction mechanisms are discussed.     

Polymere,die Benzimidazol- und Chinazolindion-Einheiten in der Hauptkette enthalten

Ohne Zusammenfassung     

Synthesis,Crystal Structure and DNA Interaction of N-（Benzimidazol- 2-ylmethyl）-5-chlorosalicylideneimine

The title compound, N-（benzimidazol-2-ylmethyl）-5-chlorosalicylideneimine, has been synthesized and characterized by X-ray single-crystal diffraction. It crystallizes in the monoclinic system, space group P21/n, with a = 8.3765（2）, b = 18.1398（4）, c = 9.4764（3）А, β= 112.141（2）°, V= 1333.74（6）А^3, Mr = 285.73, Z = 4, Dc = 1.423 g/cm^3, F（000） = 592,/z = 0.285 mm^-1, the final R = 0.0538 and wR = 0.1456 for 1917 observed reflections with I〉2σ-（I）. The fluorescence quenching of the title compound by DNA with Stern-Volmer constant of 2.8×104 M^-1 indicates that it binds to double-stranded DNA in a partial intercalation mode.     

Synthesis and Characterization of A Nickel(II) Complex With Bis(Benzimidazol-2-Ylmethyl) (2-Hydroxyethyl)Amine

This paper reports the synthesis, crystal structure and properties of two new mononuclear nickel(II) complexes, [NiL(phen)][ClO₄]₂(1) and [NiL(bpy)][ClO₄]₂(2), where L is bis(benzimidazol-2-ylmetheyl)(2-hydroxyethyl)amine and phen and bpy are 1,10-phenanthroline and 2,2'-bipyridine, respectively. The crystal structure of 1 ·2EtOH has been determined by single-crystal X-ray analysis. It crystallizes in the monoclinic system, space group C2/c, a= 24.279(2), b= 20.864(2), c= 17.635(1)Å, g = 121.730(2)°, Z= 8, R ₁= 0.064, wR ₂= 0.167. The Ni(II) ion in 1 ·2EtOH is coordinated to three nitrogen atoms and one oxygen atom of the ligand L and two nitrogen atoms of phen to form a distorted octahedron. Spectroscopic properties of 1 and 2 are reported.     

Polymere, die Benzimidazol- und Chinazolindion-Einheiten in der Hauptkette enthalten

Ohne Zusammenfassung     

2-(Benzimidazol-2-yl)-1,10-phenanthrolyl metal (Fe and Co) complexes and their catalytic behaviors toward ethylene oligomerization

The N^∧N^∧N-tridentate metal complexes, LMCl₂ (M = Fe or Co; L represents a ligand of 2-(benzimidazol-2-yl)-1,10-phenanthrolines), were synthesized and fully characterized with spectroscopic and elemental analysis. The single-crystal X-ray crystallographic analyses revealed complex 1a with a distorted octahedron geometry due to incorporating one methanol molecule, and complexes 5a and 9b with a distorted trigonal-bipyramidal geometry. Upon activation with modified methylaluminoxane (MMAO), these complexes showed good to high catalytic activities toward ethylene oligomerization. The detailed investigations were carried out to disclose the influences of various reaction conditions and nature of ligands on their performing activities of metal complexes.     

tris-(Benzimidazol-2-yl-methyl)-amine as a Versatile Building Block in Ru(II) Polypyridyl Chemistry

Summary.  tris-(Benzimidazol-2-yl-methyl)-amine, H₃ ntb, was prepared and used in the synthesis of dinuclear Ru(II) polypyridyl and polynuclear Ru(II)–Co(III) complexes of the type [Ru₂(H₂ ntb) (bpy)₄]³⁺, [Ru₂(Hntb)(phen)₄]²⁺, [(Ru₂(H₂ ntb)(bpy)₄)₂Co(en)₂]⁹⁺, and [(Ru₂(Hntb)(phen)₄)₂ Co(en)₂]⁷⁺ (bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline, en = 1,2-diaminoethane). The complexes were characterized by elemental analysis as well as spectroscopic and redox data. The luminescent properties of the complexes were also studied. The complexes showed significant antitumour and anti-HIV activities. Received May 9, 2001. Accepted (revised) June 7, 2001     

[1-(Benzimidazol-2-yl)-2-(dimethylamino)vinyl]triphenylphosphonium Chloride,A New Reagent for Heterocyclizations

Russian Journal of General Chemistry -     

Two Approaches to the Transformation of (Benzimidazol-2-ylmethyl)triphenylphosphonium Chloride into the Derivatives of Pyrimido[1,6-a]benzimidazole

The reaction of readily accessible (benzimidazol-2-ylmethyl)triphenylphosphonium chloride with acyl isothiocyanates in the presence of triethylamine, as well as consecutive treatment of the above phosphonium salt first with N,N-dimethylformamide dimethyl acetal and then with phenyl or allyl isothiocyanate gives two types of phosphorus-containing derivatives of pyrimido[1,6-a]benzimidazole with the thione group in position 3 or 1 of the condensed system. The structure of one of compounds of the first type, 3-thioxo-1-p-tolyl-3,4-dihydropyrimido[1,6-a]benzimidazol-4-ylidenetriphenylphosphorane, was determined by single crystal X-ray diffraction.     

New syntheses of condensed heterocycles from isoxazole derivatives. IV. Benzimidazol-2(3H)ones and 1-H-1,5-benzodiazepin-2(3H)one

A new synthesis of the title compounds is described. Catalytic hydrogenation of 3-R-5-R'-2-nitro-4-isoxazolecarboxanilides (III) yield compounds IV which were cyclized by refluxing in toluene with traces of p-toluenesulphonic acid. In contrast to IVa which gave directly 3-acetyl-4-phenyl-1H-1,5-benzodiazepin-2(3H)one (Va), compounds IVb and IVc afforded instead the 1-substituted benzimidazolones VIb and VIc, respectively. The structure of VIa, b, and c, VIIb and VIIc has been elucidated by chemical and spectral means including mass and nmr spectra.     

(Benzimidazol-1-yl)methyl]benzamides as bifunctional reagents for reliable inorganic-organic supramolecular synthesis

A series of ligands that utilize five-membered N-heterocycles as coordination sites, and the self-complementarity of the carboxamide functionality, have been employed in the supramolecular synthesis of Ag(I)-based extended networks. The crystal structures of eight compounds are reported: bis[4-(2-methylbenzimidazol-1-yl)methylbenzamide]silver(I) tetrafluoroborate hydrate methanol, 1; bis[3-(2-methylbenzimidazol-1-yl)methylbenzamide]silver(I) tetrafluoroborate, 2; bis[4-(5,6-dimethylbenzimidazol-1-yl)methylbenzamide]silver(I) tetrafluoroborate, 3; bis[4-(2-methylbenzimidazol-1-yl)methylbenzamide]silver(I) hexafluoroarsenate methanol, 4; bis[3-(2-methylbenzimidazol-1-yl)methylbenzamide]silver(I) hexafluoroarsenate methanol(0.5), 5; bis[4-(5,6-dimethylbenzimidazol-1-yl) methylbenzamide]silver(I) hexafluoroarsenate, 6; bis[4-(2-methylbenzimidazol-1-yl)methylbenzamide]silver(I) hexafluoroantimonate, 7; and bis[3-(2-methylbenzimidazol-1-yl)methylbenzamide]silver(I) hexafluoroantimonate, 8. An analysis of motifs and structural patterns that result from the primary intermolecular interactions in these structures, reveals that this family of ligands is capable of providing quite reliable means for propagating the linear geometry of the complex ions into extended 1-D architectures via ligand-ligand, N-H...O, hydrogen-bond interactions.     

On the Electrochemical Behaviour of Some 2,3-Dihydrothiazolo[3,2-a]Benzimidazol-3-One and 1-Ethylmercapto-3(4H)-Isoquinolones Derivatives

The electrochemical behaviour of several derivatives containing the sequence S-C-CO-N in their structure presented as such or in masked form in both aqueous and non-aqueous media are reported. The results of electrooxidation indicated that when the S atom is present as hetero atom in the structure of the molecule the main product will be the sulphone derivative, on the other hand when present in the form C=S the preferential product is the dimer. The overall redox study indicated that the azo group at C-2 is very active in both aqueous and non aqueous media. On the other hand derivatives substituted at C-2 the preferential electrochemical step is the attack of the hetero ring itself.     

1-亚甲基苯并咪唑-1,4,7-三氮环壬烷配体及其铜配合物[Cu(C14H21N5)Br]2•[CuBr4]的合成与晶体结构

采用新的方法合成了1-亚甲基苯并咪唑-1,4,7-三氮环壬烷配体, 利用该配体合成了一个新的铜配合物[Cu(C₁₄H₂₁N₅)Br]₂•[CuBr₄] ([Cu(C₁₄H₂₁N₅)Br]^＋•[CuBr₄]^2－•[Cu(C₁₄H₂₁N₅)Br]^＋), 并测定了它的晶体结构, 结果表明: 该配合物的晶体属于单斜晶系的C2/c空间群, 晶胞参数a＝1.96209(15) nm, b＝0.82319(5) nm, c＝2.39249(15) nm, α＝90.00°, β＝102.996(2)°, γ＝90.00°, V＝3.7653(4) nm³, Z＝4, μ(Mo Kα)＝8.083 mm^－1, D_c＝2.097 Mg/m³, F(000)＝2308, R＝0.0417, wR＝0.0945, GOF＝0.933. 该配合物由两个1-亚甲基苯并咪唑-1,4,7-三氮环壬烷一溴合铜配阳离子和一个四溴合铜配阴离子组成. 在两个配阳离子中, 每个Cu(II)离子与五个配位原子配位(四个氮原子和一个溴阴离子), 位于一个变形四方锥的中心. 在配阴离子中, Cu(II)离子与四个溴阴离子配位, 位于一个稍变形四面体的中心.     

Sc2MgGa2 and Y2MgGa2

Scandium magnesium gallide, Sc₂MgGa₂, and yttrium magnesium gallide, Y₂MgGa₂, were synthesized from the corresponding elements by heating under an argon atmosphere in an induction furnace. These intermetallic compounds crystallize in the tetragonal Mo₂FeB₂‐type structure. All three crystallographically unique atoms occupy special positions and the site symmetries of (Sc/Y, Ga) and Mg are m2m and 4/m, respectively. The coordinations around Sc/Y, Mg and Ga are pentagonal (Sc/Y), tetragonal (Mg) and triangular (Ga) prisms, with four (Mg) or three (Ga) additional capping atoms leading to the coordination numbers [10], [8+4] and [6+3], respectively. The crystal structure of Sc₂MgGa₂ was determined from single‐crystal diffraction intensities and the isostructural Y₂MgGa₂ was identified from powder diffraction data.