以研究生为主体力量构建化学科普平台的探索与实践

有效利用高校的科研和人才资源优势，依托陕西省"工科化学"实践教学示范中心，创建主要面向中小学生的化学科普平台。通过在科研团队基础上建设以研究生为主体、教师为指导的科普团队，并打造集知识学习、实践探索及兵器特色于一体的"ABC"科普课程体系，开设各类趣味化学及相关学科的实践项目，促进公众正确理解和认识化学，培养他们的科学精神进而提高科学素养。同时，参与科普工作也有效提升了研究生的实践能力，激发了他们从事科研的兴趣，也为研究生的培养开拓了一条新途径。     

化学类研究生培养国际化的研究——以青岛大学材料学科为例

以青岛大学化学类材料学科研究生培养国际化的研究为例,提出化学类研究生培养国际化的有效策略：（1）人才流动规模化;（2）平台建设国际化。以国内、国际产科教融合协同育人实训平台为依托,构建国内国际全方位产科教深度融合协同育人实训平台。形成了“平台搭建-学科建设-人才培养-反馈完善”的动态良性知识产业链循环,实现了研究生培养反馈、管理、评价机制,可作为全国省属高等院校化学类研究生培养国际化的推广模式。     

讲台与实验台互跨式研究生双语教学模式探索与实践

研究生双语教学是研究生教育国际化进程的必然要求。针对目前研究生双语教学中存在的问题,本文提出了一种新的研究生双语教学模式,即讲台与实验台互跨式研究生双语教学。以生物无机化学研究生双语课程为例,我们探索了讲台与实验台互跨式双语教学的实施方法。实践表明,讲台与实验台互跨式研究生双语教学模式解决了研究生培养中理论与实践相脱节的问题,不但可以全面提高研究生科研素质,而且可以提升教师科研水平。     

以“理-工-医”交叉融合实现源头创新——生物医学工程交叉学科研究生培养实践探索

针对科学技术和国家社会发展对生物医学创新型人才的需求，依托于学校的重大项目培育和新兴交叉学科研究课题，建立了生物医学工程与化学、物理、材料、电子和医学等"理-工-医"多学科交叉科研平台。基于"以人为本""全面发展"等现代教育理念和"以学生发展为中心"的高等教育思想，通过组建跨学科的研究生导师团，多导师联合指导，夯实学生多学科基础知识，加强学生对知识的理解和使用，拓宽研究生知识广度，着力培养研究生源头创新能力，打造研究生解决多学科交叉重要问题的能力。实践表明，多学科交叉科研平台在激发研究生源头创新思维、拓展专业知识、培养工程实践能力等方面起到重要的作用。对继续完善多学科交叉的研究生培养体系建设给出了建议。     

生物材料类大学生创新实验初探

为促进大学生积极参与国家大学生创新性实验计划项目,我院特推出“学业导师制”的管理模式,组织本科生按兴趣参加“科研训练”,并以科研小组为单位组织申报。以培养科研兴趣、加强科研训练、提高科研素养、实现科学理论与实验操作相结合为目的,就生物材料类项目的申请、组织实施、成果展示等方面提出相应的实施方案。     

本科生与研究生互动实验模式的探索与实践

提出了本科实验教学中本科生与研究生互动的实验教学“一二三模式”,旨在发挥科研与研究生的优势,为本科实验教学服务,提高本科实验教学质量,培养创新型人才。     

培养教育硕士专业学位研究生教学与科研技能的创新实践

为提高教育硕士专业学位研究生的培养质量,切实有效地解决人才培养中存在的实际问题,在内蒙古师范大学进行了“理论学习-实践训练-科学研究”三位一体的课程群教学改革与实践。通过任课教师和指导教师的教研合力,将多样化的有利于研究生教学能力和研究能力提高的实践活动有机地融合到专业学位课程的理论学习过程中,形成了教育硕士专业学位研究生教学和科研技能并重的创新培养模式。     

研究生参与实验室大型仪器管理的探索

阐述了研究生参与大型仪器管理的必要性、运行机制及实施环节,建立了"统一管理,专人负责,用管结合,开放使用"的管理模式.实践证明,这一措施的实施对规范大型仪器管理、提高仪器利用率以及实验室科研项目顺利进行起到了积极促进作用.     

中国科学院上海有机化学研究所

<正>中国科学院上海有机化学研究所成立于1950年5月,是一所历史悠久、集科研与教育为一体的国内外著名综合性研究机构。目前我所在学研究生441名。新建成的实验大楼、完备的实验条件、先进     

化学专业学术型硕士研究生培养与本科科研训练有效衔接的探究

阐述了高水平学术型硕士研究生培养与本科科研体验衔接的基本情况,以化学专业为例,就学术型硕士培养与本科创新性科研实践的衔接模式进行了详细的剖析,指出2者的衔接有助于高层次、高科研水平与高创新能力的硕士研究生培养。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.     

Chemistry of heterocyclic compounds at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, over 50 years (Review)

The review contains a concise historical account and information on the most significant researches undertaken by the staff at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences on the Chemistry of Heterocyclic Compounds. Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1502, October, 2008.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.