The blood flow and the motion of vessel wall

The correlation problem between the blood flow and the motion of vessel wall in the mammalian circulatory system is discussed in this paper. Supposing the blood flow is under the stable oscillatory condition, a set of formulas for velocity distribution, pressure distribution, displacement of vessel wall and constraining stress are obtained. Kuchar’s formulas are extended from steady flow to unsteady oscillatory flow by means of the formulas obtained in this paper. The problem of elasticity effect of vessel wall is also discussed.     

Role of response to changes in flow rate in the regulation of vessel radius and blood flow

Estimates are presented for the effect of susceptibility of the inner surface of the blood vessel wall to shear stress on changes in diameter and volume blood flow rate. The model of thin-walled vessel with radius controlled by two parameters is used. The effect of rheological factors, hematocrit, and oxygen content in blood on the value of vessel response to a change in shear stress is considered. The estimates showed that the contribution of the vessel response in question to a change in blood volume flow rate amounts tens per cent. The influence of rheological (Fahraeus and Fahraeus-Lindqvist) effects on flow rate lies within several per cent. The role of the vessel response considered increases with anaemia: at low hematocrit its contribution to increase in flow rate exceeds 10%. Variation of oxygen concentration within the normal range has almost no effect on the hemodynamic parameters. With hypoxia, on the contrary, the participation of this response on changes in flow rate weakens: in severe hypoxia decrease in blood flow rate owing to a change in oxygen concentration equals approximately 9%.     

局部扩张动脉管血液振荡流的切应力分布

本文求解局部缓慢扩张动脉管中血液振荡流的基本方程，得到血管内血液的流速与压力梯度的关系。通过导出压力梯度沿局部扩张管轴向的变化特性。建立利用扩张段上游血管均匀段中心流速波形确定局部扩张管中血液流的速度和切应力分布的方法，文章以人体颈动脉余弦扩张为例进行分析。详细讨论了局部扩张对血管壁切应力及其梯度分布的影响。数值结果表明，在与刚性均匀管中管壁切应力沿轴向保持不变不同，在局部扩张段，管壁切应力将随着血管半径的增大而减小，因而管壁切应力梯度一般不为零，甚至在某些位置达到相当大的数值。另外，随着血管扩张程度的增加，管壁切应力还将进一步减小，而且管壁切应力梯度也将进一步增大，血管扩张导致管壁切应力的这些变化将直接影响血管壁的结构和功能，使其产生适应性的变化。     

THE COUPLE MOTION BETWEEN VESSEL WALL AN DBLOOD IN THE ENTRANCE REGION OF A TAPERED VESSEL

ＴＨＥＣＯＵＰＬＥＭＯＴＩＯＮＢＥＴＷＥＥＮＶＥＳＳＥＬＷＡＬＬＡＮＤＢＬＯＯＤＩＮＴＨＥＥＮＴＲＡＮＣＥＲＥＧＩＯＮＯＦＡＴＡＰＥＲＥＤＶＥＳＳＥＬＣｅｎＲｅｎ－ｊｉｎｇ（岑人经）ＱｉｎＣｈａｎ（秦婵）ＴａｎＺｈｅ－ｄｏｎｇ（谭哲东）（ＳｏｕｔｈＣ...     

A calculation method for blood flow velocity distribution in smallep elocd vessels

The calculative method presented in this paper is based on an improvement of boundary conditions for a micro-continuum fluid model with blood flow assuming that the blood cell velocity at blood vessel wall is unequal to zero. As for steady state flood flow equation (flow in vitre—a rigid circular tube) presented by Eringen, the magnitude of the blood cell gyroscopic velocity at blood vessel wall and the slope of the blood cell gyroscopic velocity distribution curve at the axis of the blood vessel are assumed. From the above mentioned assumptions the calculating method of velocity distribution curve in blood vessel is derived. The curve calculated by this method is compared with the test curve measured by Bugliarello and Hayden. The results obtained by Turk, Sylvester and Ariman as well as with this method are compared with each other, too.     

Mathematical modeling and parametric investigation of blood flow through a stenosis artery

In this study, a mathematical model is formulated to examine the blood flow through a cylindrical stenosed blood vessel. The stenosis disease is caused because of the abnormal narrowing of flow in the body. This narrowing causes serious health issues like heart attack and may decrease blood flow in the blood vessel. Mathematical modeling helps us analyze such issues. A mathematical model is considered in this study to explore the blood flow in a stenosis artery and is solved numerically with the finite difference method. The artery is an elastic cylindrical tube containing blood defined as a viscoelastic fluid. A complete parametric analysis has been done for the flow velocity to clarify the applicability of the defined problem. Moreover, the flow characteristics such as the impedance, the wall shear stress in the stenotic region, the shear stresses in the throat of the stenosis and at the critical stenosis height are discussed. The obtained results show that the intensity of the stenosis occurs mostly at the highest narrowing areas compared with all other areas of the vessel, which has a direct impact on the wall shear stress. It is also observed that the resistive impedance and wall shear pressure get the maximum values at the critical height of the stenosis.

     

Regulation of the lumen of a resistance blood vessel by mechanical stimuli

The flow in a vessel able to regulate its lumen under the action of mechanical stimuli, the variation of the pressure difference between the inner and outer surfaces of the vessel wall and the blood flow velocity, is described. This ability is determined by the effect of the mechanical stimuli on the degree of activation of smooth muscle cells in the vessel wall. In order to describe the active properties of the wall, two controlling parameters which have the sense of the concentration of free calcium ions in the cytoplasm of smooth muscle cells and the average concentration of nitric oxide in the smooth muscle layer, are introduced. The approach proposed makes it possible to estimate both the degree of participation of each mechanical stimulus in vessel lumen regulation and the result of interaction of two differently directed vascular responses. The calculations show that both the magnitude and direction of the radius response to a mechanical stimulus depend on the initial state of the vessel wall. The role of the vessel wall sensitivity to mechanical stimuli in the stabilization of the blood flow-rate and the variation of the radius along the vessel is considered.     

Pulsatile blood flow in a resistance vessel

The quasi-one-dimensional Newtonian fluid flow in an active vessel in which the inlet pressure oscillates about a mean value is considered. The vascular wall is assumed to display the Bayliss effect and a reaction to changes in blood flow. The first is characterized by the dependence of the contractility of the vascular smooth-muscle cells on the intravascular pressure and the second by the sensitivity of the endothelial cells to the wall shear stress. The dependence of the period-average radius and blood flow rate on the mean value and pulsation amplitude and frequency of the inlet pressure is investigated numerically. The characteristics are compared for the passive vessel, the vessel with the Bayliss effect, and the vessel with both reactions.     

受支架支撑的血管管壁变形及应力分析

摘要：为了计算动脉粥样硬化和局部斑块形成的堵塞对血管壁工作状态的影响,本文根据血液流动的连续性方程、运动方程及管壁运动方程,在给定了血压波形函数的基础上,求得了狭窄血管管壁的径向位移及环向应力。分析了不同狭窄程度对血管壁变形及应力的影响;给出了不同狭窄情况下及局部斑块硬化程度不同时,血管植入支架所需的作用力。从而计算出了植入支架后血管壁的径向位移及应力状态。本文的研究结果可供临床上对狭窄血管植入支架后的变形与受力分析,和支架的正确安放参考,可避免发生堵塞严重或血管过渡硬化时,由于安放支架不当而使发生血管破裂的医疗事故。     

Noise Field in the Human Chest Due to Turbulent Flow in a Larger Blood Vessel

An acoustic model of a larger human blood vessel is developed. This model takes into account the main features of the acoustic generation and propagation of noise in the human chest from the source (turbulent pressure fluctuations in blood flow) to a receiver resting on the skin, and allows the consideration of a simple stenotic narrowing in the vessel. The low Mach number turbulent wall pressure models of Corcos, Chase, Ffowcs Williams, and Smol'yakov and Tkachenko are used to describe random sources in the vessel. The relationships obtained permit one to analyse the dependence of the resultant acoustic field in the thorax on the parameters of the blood flow and the vessel, and show the possibility of finding characteristic signs of the presence of a stenosis by comparison of noise fields from intact and diseased arteries. This revised version was published online in July 2006 with corrections to the Cover Date.     

A Two-Layer Mathematical Model of Blood Flow in Porous Constricted Blood Vessels

In this paper, we discussed a mathematical model for two-layered non-Newtonian blood flow through porous constricted blood vessels. The core region of blood flow contains the suspension of erythrocytes as non-Newtonian Casson fluid and the peripheral region contains the plasma flow as Newtonian fluid. The wall of porous constricted blood vessel configured as thin transition Brinkman layer over layered by Darcy region. The boundary of fluid layer is defined as stress jump condition of Ocha-Tapiya and Beavers–Joseph. In this paper, we obtained an analytic expression for velocity, flow rate, wall shear stress. The effect of permeability, plasma layer thickness, yield stress and shape of the constriction on velocity in core & peripheral region, wall shear stress and flow rate is discussed graphically. This is found throughout the discussion that permeability and plasma layer thickness have accountable effect on various flow parameters which gives an important observation for diseased blood vessels.     

The steady/pulsatile flow and macromolecular transport in T-bifurcation blood vessels

IntroductionThefluiddynamicsofbloodcyclesystemplayanimportantroleinthepathogenesisofatherosclerosis.ThephysiologicalanatomyfoundthattheatherosclerosisappearsoftenatthebifurcationorcurvedflowareatoallkindsofRefs.[1 ,2 ] .Theshearstressvariesgreatlyinthoseareaandinfluencesthemacromoleculartransportacrossthebloodwall[3,4].Thus ,theinvestigationoftheflowandmacromoleculartransportinthesecomplexbloodvesselaandthecorrelationbetweenthemareinterestingtoresearchers.Intheseaspect,Liepschstudiedtheflowi…     

Pulsatile blood flow in large arteries: comparative study of Burton’s and McDonald’s models

To get a clear picture of the pulsatile nature of blood flow and its role in the pathogenesis of atherosclerosis, a comparative study of blood flow in large arteries is carried out using the two widely used models, McDonald＇s and Burton＇s models, for the pressure gradient. For both models, the blood velocity in the lumen is obtained analytically. Elaborate investigations on the wall shear stress （WSS） and oscillatory shear index （OSI） are carried out. The results are in good agreement with the available data in the literature. The superiority of McDonald＇s model in capturing the pulsatile nature of blood flow, especially the OSI, is highlighted. The present investigation supports the hypothesis that not only WSS but also OSI are the essential features determining the pathogenesis of atherosclerosis. Finally, by reviewing the limitations of the present investigation, the possibility of improvement is explored.     

An analysis of the flow of blood through thick-walled vessels,considering the effect of tethering

A theoretical analysis of the flow of blood through the blood vessel is presented. Both the radial and longitudinal tetherings are accounted for. By taking the orthotropicity of the wall tissues into consideration, blood is treated as a Newtonian, viscous and incompressible fluid. The applicability of the analysis is illustrated through the numerical computations of the derived analytical expressions by using experimentally determined values of the material parameters and the effect of tethering on the phase velocities of blood flow is thereby quantified.     

Stokes flow through a permeable tube

Pressure-driven Stokes flow through a circular tube with a permeable wall is considered as a model of blood flow through a capillary vessel. Fluid penetrates the tube wall over a test section according to Starling law relating the normal fluid velocity to the transmural pressure defined as the difference between the wall and the uniform ambient pressure. The problem is formulated using the integral representation for Stokes flow, and the solution is computed with high accuracy using a boundary-element method for specified values of the wall permeability and percentage of fluid escaping through the walls. The results illustrate the structure of the flow and validate the predictions of a model based on the assumption of locally unidirectional flow for sufficiently small permeability.     

An analysis model of pulsatile blood flow in arteries

IntroductionTheperiodicallypulsatilebloodflowinthearterycausesthecircumferentialandaxialmotionoftheelasticbloodvesselandinturntheoscillationofthevesselaffectsthatofthebloodflow .Womersley[1]resolvedsuccessfullythisfluid_solidcouplingproblembysolvingbothlinearNavier_Stokesequationsandthemotionequationsofthethin_walledelastictubeandgainedtheexpressionsofthebloodflowvelocitiesandthevasculardisplacements.Histheoryhasbeenthebasisforthequantitativeanalysisoftherelationshipofthearterialstructureandi…     

The stress analysis of vessel wall in the entrance region of a tapered vessel

ＴＨＥＳＴＲＥＳＳＡＮＡＬＹＳＩＳＯＦＶＥＳＳＥＬＷＡＬＬＩＮＴＨＥＥＮＴＲＡＮＣＥＲＥＧＩＯＮＯＦＡＴＡＰＥＲＥＤＶＥＳＳＥＬＣｅｎＲｅｎ－Ｊｉｎｇ（岑人经）ＴａｎＺｈｅ－ｄｏｎｇ（谭哲东）ＣｈｅｎＺｈｅｎｇ－ｚｏｎｇ（陈正宗）（ＳｏｕｔｈＣｈｉｎ...     

Effect of swirling flow on platelet concentration distribution in small-caliber artificial grafts and end-to-end anastomoses

Platelet concentration near the blood vessel wall is one of the major factors in the adhesion of platelets to the wall.In our previous studies,it was found that swirling flows could suppress platelet adhesion in small-caliber artificial grafts and end-to-end anastomoses.In order to better understand the beneficial effect of the swirling flow,we numerically analyzed the near-wall concentration distribution of platelets in a straight tube and a sudden tubular expansion tube under both swirling flow and normal flow conditions.The numerical models were created based on our previous experimental studies.The simulation results revealed that when compared with the normal flow,the swirling flow could significantly reduce the near-wall concentration of platelets in both the straight tube and the expansion tube.The present numerical study therefore indicates that the reduction in platelet adhesion under swirling flow conditions in small-caliber arterial grafts,or in end-to-end anastomoses as observed in our previous experimental study,was possibly through a mechanism of platelet transport,in which the swirling flow reduced the near-wall concentration of platelets.     

一种骨小管中液体流动产生的流量及切应力模型

骨组织受力变形后其内部液体就会流动,同时在其微观结构——骨单元壁中扩散,并进一步产生一系列与骨液流动相关的物理效应,如流体剪切应力、流动电位等,这些物理效应被细胞感知并做出破骨或成骨等反应,来使骨适应外部载荷环境.鉴于骨组织产生的内部液体流动很难实验测定,理论模拟是目前的主要研究手段.基于骨单元的多孔弹性性质建立了骨小管内部液体的流动模型,该模型将骨单元所受的外部载荷与骨小管内部液体的压力、流速、流量和切应力联系起来,并进一步可以研究其力传导与力电传导机制.骨小管模型的建立分别基于中空和考虑哈弗液体的骨单元模型,并考虑了骨单元外壁的弹性约束和刚性位移约束两种边界条件.最终得到骨单元在外部轴向载荷作用下,骨小管内部液体的流量及流体切应力的解析解.结果表明:骨小管中的液体流量与流体切应力都正比于应变载荷幅值和频率,并由载荷的应变率决定.因此应变率可以作为控制流量和流体切应力的一种生理载荷因素.流量随着骨小管半径的增大而非线性增大,而流体切应力则随着骨小管半径的增大而线性增大.此外,在相同的载荷下,含哈弗液体的骨单元的模型中,骨小管中液体的流量和切应力均大于中空骨单元模型.     

Effects of magnetic field,porosity, and wall properties for anisotropically elastic multi-stenosis arteries on blood flow characteristics

A mathematical model for blood flow through an elastic artery with multistenosis under the effect of a magnetic field in a porous medium is presented. The considered arterial segment is simulated by an anisotropically elastic cylindrical tube filled with a viscous incompressible electrically conducting fluid representing blood. An artery with mild local narrowing in its lumen forming a stenosis is analyzed. The effects of arterial wall parameters represent viscoelastic stresses along the longitudinal and circumferential directions T _t and T _θ , respectively. The degree of anisotropy of the vessel wall γ, total mass of the vessel, and surrounding tissues M and contributions of the viscous and elastic constraints to the total tethering C and K respectively on resistance impedance, wall shear stress distribution, and radial and axial velocities are illustrated. Also, the effects of the stenosis shape m, the constant of permeability X, the Hartmann number H _α and the maximum height of the stenosis size δ on the fluid flow characteristics are investigated. The results show that the flow is appreciably influenced by surrounding connective tissues of the arterial wall motion, and the degree of anisotropy of the vessel wall plays an important role in determining the material of the artery. Further, the wall shear stress distribution increases with increasing T _t and γ while decreases with increasing T _θ , M, C, and K. Transmission of the wall shear stress distribution and resistance impedance at the wall surface through a tethered tube are substantially lower than those through a free tube, while the shearing stress distribution at the stenosis throat has inverse characteristic through totally tethered and free tubes. The trapping bolus increases in size toward the line center of the tube as the permeability constant X increases and decreases with the Hartmann number Ha increased. Finally, the trapping bolus appears, gradually in the case of non-symmetric stenosis, and disappears in the case of symmetric stenosis. The size of trapped bolus for the stream lines in a free isotropic tube (i.e., a tube initially unstressed) is smaller than those in a tethered tube.