Mathematical modeling and parametric investigation of blood flow through a stenosis artery

In this study, a mathematical model is formulated to examine the blood flow through a cylindrical stenosed blood vessel. The stenosis disease is caused because of the abnormal narrowing of flow in the body. This narrowing causes serious health issues like heart attack and may decrease blood flow in the blood vessel. Mathematical modeling helps us analyze such issues. A mathematical model is considered in this study to explore the blood flow in a stenosis artery and is solved numerically with the finite difference method. The artery is an elastic cylindrical tube containing blood defined as a viscoelastic fluid. A complete parametric analysis has been done for the flow velocity to clarify the applicability of the defined problem. Moreover, the flow characteristics such as the impedance, the wall shear stress in the stenotic region, the shear stresses in the throat of the stenosis and at the critical stenosis height are discussed. The obtained results show that the intensity of the stenosis occurs mostly at the highest narrowing areas compared with all other areas of the vessel, which has a direct impact on the wall shear stress. It is also observed that the resistive impedance and wall shear pressure get the maximum values at the critical height of the stenosis.

     

Hydromagnetic free convection flow with induced magnetic field effects

An exact solution is presented for the hydromagnetic natural convection boundary layer flow past an infinite vertical flat plate under the influence of a transverse magnetic field with magnetic induction effects included. The transformed ordinary differential equations are solved exactly, under physically appropriate boundary conditions. Closed-form expressions are obtained for the non-dimensional velocity (u), non-dimensional induced magnetic field component (B _x ) and wall frictional shearing stress i.e. skin friction function (τ _x ) as functions of dimensionless transverse coordinate (η), Grashof free convection number (G _r ) and the Hartmann number (M). The bulk temperature in the boundary layer (Θ) is also evaluated and shown to be purely a function of M. The Rayleigh flow distribution (R) is derived and found to be a function of both Hartmann number (M) and the buoyant diffusivity parameter (ϑ ^*). The influence of Grashof number on velocity, induced magnetic field and wall shear stress profiles is computed. The response of Rayleigh flow distribution to Grashof numbers ranging from 2 to 200 is also discussed as is the influence of Hartmann number on the bulk temperature. Rayleigh flow is demonstrated to become stable with respect to the width of the boundary layer region and intensifies with greater magnetic field i.e. larger Hartman number M, for constant buoyant diffusivity parameter ϑ ^*. The induced magnetic field (B _x ), is elevated in the vicinity of the plate surface with a rise in free convection (buoyancy) parameter G _r , but is reduced over the central zone of the boundary layer regime. Applications of the study include laminar magneto-aerodynamics, materials processing and MHD propulsion thermo-fluid dynamics.     

Elastic stresses in bodies with elliptic,parabolic, and tunnel cracks

The paper gives explicit expressions of the elastic T-stress components T _I, T _II, and T _III for an elliptic crack in an unbounded body under uniform pressure and bending and expressions of all the T-stress components for parabolic and tunnel cracks under uniform loading. These formulas are derived by analyzing the asymptotic behavior of the stress components near the crack front using special harmonic functions. The dependence of the T-stresses on Poisson’s ratio, semiaxes and parametric angle of the elliptic crack is studied. The expressions of T _I, T _II, and T _III for a penny-shaped crack under arbitrary uniform pressure and bending follow as a special case from the respective expressions for an elliptic crack __________ Translated from Prikladnaya Mekhanika, Vol. 43, No. 8, pp. 57–70, August 2007.     

Pulsatile flows in a lateral aneurysm anchored on a stented and curved parent vessel

We present particle tracking velocimetry measurements and flow visualization of pulsatile flow fields in a stented cerebrovascular lateral aneurysm model with a wide ostium anchored on a curved parent vessel. Among the stent parameters, the blocking ratioC _α ranging from 0% to 75% was selected to study its effect on the changes of intra-aneurysmal hemodynamics for the reference of minimally invasive endovascular aneurysm treatment. The Womersley number was 3.9 and the mean, peak, and minimal Reynolds numbers based on the bulk average velocity and diameter of the parent vessel were 600, 850, and 300, respectively. The results are characterized in terms of velocity vector field, coded streak images, region averaged velocity, vorticity, and wall shear stress. A critical range ofC _α related to the inflow location as well as the shape and number of intra-aneurysmal vortices is identified. The intra-aneurysmal flow activity, vortex strength, and wall shear stress are found to decrease with increasingC _α. Among theC _α examined,C _α=75% is the most favorable in attenuating the risk of aneurysmal rupture and promoting intra-aneurysmal thrombus.     

Measurements and scaling of wall shear stress fluctuations

Measurements of velocity and wall shear stress fluctuations were made in an external turbulent boundary layer developed over a towed surface-piercing flat plate. An array of eight flush-mounted wall shear stress sensors was used to compute the space-time correlation function. A methodology for in situ calibration of the sensors for ship hydrodynamic applications is presented. The intensity of the wall shear stress fluctuations, τ _rms/τ _avg was measured as 0.25 and 0.36 for R _θ =3,150 and 2,160 respectively. The probability density is shown to exhibit positive skewness, and lack of flow reversals at the wall. Correlations between velocity and wall shear stress fluctuations are shown to collapse with outer boundary layer length and velocity scales, verifying the existence of large-scale coherent structures which convect and decay along the wall at an angle of inclination varying from 10 to 13° over the range of Reynolds numbers investigated. The wall shear stress convection velocity determined from narrow band correlation measurements is shown to scale with outer variables. The space-time correlation of the wall shear is shown to exhibit a well-defined convective ridge, and to decay 80% over approximately 3δ for R _θ =3,150. Published online: 7 November 2002     

Viscoelastic properties of ultra-high viscosity alginates

Ultra-high viscosity alginates were extracted from the brown seaweeds Lessonia nigrescens (UHV_N, containing 61% mannuronate (M) and 2% guluronate (G)) and Lessonia trabeculata (UHV_T, containing 22% M and 78% G). The viscoelastic behavior of the aqueous solutions of these alginates was determined in shear flow in terms of the shear stress σ ₂₁, the first normal stress difference N ₁, and the shear viscosity η in isotonic NaCl solutions (0.154 mol/L) at T = 298 K in dependence of the shear rate [(g)\dot]\dot{\gamma} for solutions of varying concentrations and molar masses (3–10 × 10⁵ g/mol, homologous series was prepared by ultrasonic degradation). Data obtained in small-amplitude oscillatory shear (SAOS) experiments obey the Cox–Merz rule. For comparison, a commercial alginate with intermediate chemical composition was additionally characterized. Particulate substances which are omnipresent in most alginates influenced the determination of the material functions at low shear rates. We have calculated structure–property relationships for the prediction of the viscosity yield, e.g., η–M _w–c–[(g)\dot]\dot{\gamma} for the Newtonian and non-Newtonian region. For the highest molar masses and concentrations, the elasticity yield in terms of N ₁ could be determined. In addition, the extensional flow behavior of the alginates was measured using capillary breakup extensional rheometry. The results demonstrate that even samples with the same average molar mass but different molar mass distributions can be differentiated in contrast to shear flow or SAOS experiments.     

Thermocapillary convection in an annular cylindrical container

The liquid–gas interface of a liquid in an annular container is subjected to a temperature gradient. Since shear stress on the free liquid surface depends on the temperature it shall create a variable shear stress on the surface which in turn yields by viscous traction a thermocapillary convection in the bulk of the liquid. For constant temperature T ₂ > T ₁ on the outer cylindrical wall and T ₁ on the inner wall a steady convection shall emerge. The morphology of the ensuing flow is investigated as a function of the diameter ratio and the liquid height ratio and exhibits the growth of bottom rim vortex rings, which unite to single vortex rings of opposite flow direction to the original single strong vortex ring above it. The results also show how such a system depends on the magnitude of the diameter ratio and the liquid height ratio. The evaluation of the results exhibits the evolution of vortex rings.     

Rheo-PIV of a shear-banding wormlike micellar solution under large amplitude oscillatory shear

We explore the behavior of a wormlike micellar solution under both steady and large amplitude oscillatory shear (LAOS) in a cone–plate geometry through simultaneous bulk rheometry and localized velocimetric measurements. First, particle image velocimetry is used to show that the shear-banded profiles observed in steady shear are in qualitative agreement with previous results for flow in the cone–plate geometry. Then under LAOS, we observe the onset of shear-banded flow in the fluid as it is progressively deformed into the non-linear regime—this onset closely coincides with the appearance of higher harmonics in the periodic stress signal measured by the rheometer. These harmonics are quantified using the higher-order elastic and viscous Chebyshev coefficients e _n and v _n , which are shown to grow as the banding behavior becomes more pronounced. The high resolution of the velocimetric imaging system enables spatiotemporal variations in the structure of the banded flow to be observed in great detail. Specifically, we observe that at large strain amplitudes (γ ₀ ≥ 1), the fluid exhibits a three-banded velocity profile with a high shear rate band located in-between two lower shear rate bands adjacent to each wall. This band persists over the full cycle of the oscillation, resulting in no phase lag being observed between the appearance of the band and the driving strain amplitude. In addition to the kinematic measurements of shear banding, the methods used to prevent wall slip and edge irregularities are discussed in detail, and these methods are shown to have a measurable effect on the stability boundaries of the shear-banded flow.     

Simulation of heat and chemical reactions on Reiner Rivlin fluid model for blood flow through a tapered artery with a stenosis

In the present article, we have analyzed the effects of heat and mass transfer on Reiner Rivlin fluid model for blood flow through a tapered artery with a stenosis. The constitutive equations for a Reiner Rivlin fluid have been modelled in cylindrical coordinates. A perturbation series in dimensionless Reiner Rivlin fluid parameter (λ ₁ ≪ 1) have been used to obtain explicit forms for the velocity, temperature, concentration, resistance impedance, wall shear stress and shearing stress at the stenosis throat. The graphical results of different type of tapered arteries i.e. converging tapering, diverging tapering, non-tapered artery have been examined for different parameters of interest.     

One Equation Model for Turbulent Channel Flow with Second Order Viscoelastic Corrections

A modified second order viscoelastic constitutive equation is used to derive a k–l type turbulence closure to qualitatively assess the effects of elastic stresses on fully-developed channel flow. Specifically, the second order correction to the Newtonian constitutive equation gives rise to a new term in the momentum equation involving the time-averaged elastic shear stress and in the turbulent kinetic energy transport equation quantifying the interaction between the fluctuating elastic stress and rate of strain tensors, denoted by P _w , for which a closure is developed and tested. This closure is based on arguments of isotropic turbulence and equilibrium in boundary layer flows and a priori P _w could be either positive or negative. When P _w is positive, it acts to reduce the production of turbulent kinetic energy and the turbulence model predictions qualitatively agree with direct numerical simulation (DNS) results obtained for more realistic viscoelastic fluid models with memory which exhibit drag reduction. In contrast, P _w  < 0 leads to a drag increase and numerical breakdown of the model occurs at very low values of the Deborah number, which signifies the ratio of elastic to viscous stresses. Limitations of the turbulence model primarily stem from the inadequacy of the k–l formulation rather than from the closure for P _w . An alternative closure for P _w , mimicking the viscoelastic stress work predicted by DNS using the Finitely Extensible Nonlinear Elastic-Peterlin fluid model, which is mostly characterized by P _w  > 0 but has also a small region of negative P _w in the buffer layer, was also successfully tested. This second model for P _w leads to predictions of drag reduction, in spite of the enhancement of turbulence production very close to the wall, but the equilibrium conditions in the inertial sub-layer were not strictly maintained.     

Effect of couple stresses on the flow in a constricted annulus

The flow of an incompressible couple stress fluid in an annulus with local constriction at the outer wall is considered. This configuration is intended as a simple model for studying blood flow in a stenosed artery when a catheter is inserted into it. The effects couple stress fluid parameters α and σ, height of the constriction (ε), and ratio of radii (k) on the impedance and wall shear stresses are studied graphically. Graphical results show that the resistance to the flow as well as the wall shear stress increases as the ratio of the radii increases and decreases as the couple stress fluid parameters increases.     

Further Study on Pure Shear

It is known that the Cauchy stress tensor T is a pure shear when trT = 0. An elementary derivation is given for a coordinate system such that, when referred to this coordinate system, the diagonal elements of T vanish while the off-diagonal elements τ ₁, τ ₂, τ ₃, are the pure shears. The structure of τ _i (i = 1, 2, 3) depends on one non-dimensional parameter q = 54(detT)² / [tr(T ²)]³, 0 ≤ q ≤ 1. When q = 0, one of the three τ _i vanishes. A coordinate system can be chosen such that the remaining two have the same magnitude or one of the remaining two also vanishes. When q = 1, all three τ _i have the same magnitude. However, there is a one-parameter family of coordinate systems that gives the same three τ _i . For q ≠ 0 or 1, none of the three τ _i vanishes and the three τ _i in general have different magnitudes. Nevertheless, a coordinate system can be chosen such that two of the three τ _i have the same magnitude. ^★Professor Emeritus of University of Illinois at Chicago and Consulting Professor of Stanford University.     

Analytical Solution for Radial Deformations of Functionally Graded Isotropic and Incompressible Second-Order Elastic Hollow Spheres

We analytically analyze radial expansion/contraction of a hollow sphere composed of a second-order elastic, isotropic, incompressible and inhomogeneous material to delineate differences and similarities between solutions of the first- and the second-order problems. The two elastic moduli are assumed to be either affine or power-law functions of the radial coordinate R in the undeformed reference configuration. For the affine variation of the shear modulus μ, the hoop stress for the linear elastic (or the first-order) problem at the point R=(R _ou R _in (R _ou +R _in )/2)^1/3 is independent of the slope of the μ vs. R line. Here R _in and R _ou equal, respectively, the inner and the outer radius of the sphere in the reference configuration. For μ(R)∝R ⁿ , for the linear problem, the hoop stress is constant in the sphere for n=1. However, no such results are found for the second-order (i.e., materially nonlinear) problem. Whereas for the first-order problem the shear modulus influences only the radial displacement and not the stresses, for the second-order problem the two elastic constants affect both the radial displacement and the stresses. In a very thick homogeneous hollow sphere subjected only to pressure on the outer surface, the hoop stress at a point on the inner surface depends upon values of the two elastic moduli. Thus conclusions drawn from the analysis of the first-order problem do not hold for the second-order problem. Closed form solutions for the displacement and stresses for the first-order and the second-order problems provided herein can be used to verify solutions of the problem obtained by using numerical methods.     

磁场和Hall电流对狭窄动脉中血液流动的影响

A micropolar model for blood simulating magnetohydrodynamic flow through a horizontally nonsymmetric but vertically symmetric artery with a mild stenosis is presented. To estimate the effect of the stenosis shape, a suitable geometry has been considered such that the horizontal shape of the stenosis can easily be changed just by varying a parameter referred to as the shape parameter. Flow parameters, such as velocity, the resistance to flow （the resistance impedance）, the wall shear stress distribution in the stenotic region, and its magnitude at the maximum height of the stenosis （stenosis throat）, have been computed for different shape parameters, the Hartmann number and the Hall parameter. This shows that the resistance to flow decreases with the increasing values of the parameter determining the stenosis shape and the Hail parameter, while it increases with the increasing Hartmann number. The wall shear stress and the shearing stress on the wall at the maximum height of the stenosis possess an inverse characteristic to the resistance to flow with respect to any given value of the Hartmann number and the Hall parameter. Finally, the effect of the Hartmann number and the Hall parameter on the horizontal velocity is examined.     

An investigation of electromagnetic wave propagation in plasma by shock tube

This paper presents the electromagnetic wave propagation characteristics in plasma and the attenuation coefficients of the microwave in terms of the parameters he, v, w, L, wb. The φ800 mm high temperature shock tube has been used to produce a uniform plasma. In order to get the attenuation of the electromagnetic wave through the plasma behind a shock wave, the microwave transmission has been used to measure the relative change of the wave power. The working frequency is f = (2-35)GHz (ω=2πf, wave length A =15cm-8mm). The electron density in the plasma is ne = (3&#215;10^10-1&#215;10^14) cm^-3. The collision frequency v = (1&#215;10^8-6&#215;10^10) Hz. The thickness of the plasma layer L = (2-80)cm. The electron circular frequency ωb=eBo/me, magnetic flux density B0 = (0-0.84)T. The experimental results show that when the plasma layer is thick (such as L/λ≥10), the correlation between the attenuation coefficients of the electromagnetic waves and the parameters ne,v,ω, L determined from the measurements are in good agreement with the theoretical predictions of electromagnetic wave propagations in the uniform infinite plasma. When the plasma layer is thin (such as when both L and A are of the same order), the theoretical results are only in a qualitative agreement with the experimental observations in the present parameter range, but the formula of the electromagnetic wave propagation theory in an uniform infinite plasma can not be used for quantitative computations of the correlation between the attenuation coefficients and the parameters ne,v,ω, L. In fact, if ω&lt;ωp, v^2&lt;&lt;ω^2, the power attenuations K of the electromagnetic waves obtained from the measurements in the thin-layer plasma are much smaller than those of the theoretical predictions. On the other hand, if ω&gt;ωp, v^2&lt;&lt;ω^2 (just v≈f), the measurements are much larger than the theoretical results. Also, we have measured the electromagnetic wave power attenuation value under the magnetic field and without a magnetic field. The result indicates that the value measured under the magnetic field shows a distinct improvement.     

Detection and quantification of industrial polyethylene branching topologies via Fourier-transform rheology,NMR and simulation using the Pom-pom model

The significance of sparse long-chain branching in polyolefines towards mechanical properties is well-known. Topology is a very important structural property of polyethylene, as is molecular weight distribution. The method of Fourier-transform rheology (FTR) and melt state nuclear magnetic resonance (NMR) is applied for the detection and quantification of branching topology (number of branches per molecule), for industrial polyethylenes of various molecular weight and molecular weight distributions. FT rheology consists of studying the development of higher harmonics contribution of the stress response to a large amplitude oscillatory shear deformation. In particular, when applying large-amplitude oscillatory shear (LAOS), one observes the development of mechanical higher harmonic contributions at 3ω ₁, 5ω ₁,..., in the shear stress response. We correlate the relative intensity, I _3/1, and phase Φ ₃ of these harmonics with structural properties of industrial polyethylene, i.e. polymer topology and molecular weight distribution. Experiments are complemented by numerical simulations, using a multimode differential Pom-pom constitutive model (DCPP formulation), by fitting to the experimental linear and nonlinear viscoelastic behaviours. Simulation results in the nonlinear regime are correlated with molecular properties of the “pom-pom” macromolecular architecture. Qualitative agreement is found between predicted and experimental FT rheology results.     

On a Free Convection Problem Over a Vertical Flat Surface in a Porous Medium

The problem of the free convection boundary-layer flow over a semi-infinite vertical flat surface in a porous medium is considered, in which the surface temperature has a constant value T₁ at the leading edge, where T₁ is above the ambient temperature, and takes a value T₂ at a given distance L along the surface, varying linearly between these two values and remaining constant afterwards. Numerical solutions of the boundary-layer equations are obtained as well as solutions valid for both small and large distance along the surface. Results are presented for the three cases, when the temperature T₂ is greater, equal or less than the ambient temperature T_∞. In the first case, T₂ > T_∞, a boundary-layer flow develops along the surface starting with a flow associated with the temperature difference T₁ − T_∞ at the leading edge and approaching a flow associated with the temperature difference T₂ − T_∞ at large distances. In the second case, T₂ = T_∞, the convective flow set up on the initial part of the surface drives a wall jet in the region where the surface temperature is the same as ambient. In the final case, T₂ < T_∞, a singularity develops in the numerical solution at the point where the surface temperature becomes T_∞. The nature of this singularity is discussed.     

An experimental study of a two-dimensional plane turbulent wall jet

 Laser-Doppler measurements were conducted in a plane turbulent wall jet at a Reynolds number based on inlet velocity, Re ₀, of 9600. The initial development as well as the fully developed flow was studied. Special attention was given to the near-wall region, including the use of small measuring volumes and the application of specific near-wall data corrections, so that wall shear stresses were determined directly from the mean velocity gradient at the wall using only data below y ⁺=4. It was possible to resolve the inner peak in the streamwise turbulence intensity as well as the inner (negative) peak in the shear stress. Limiting values of (u′)⁺ and uv ⁺ were determined. Turbulence data from the outer region of the flow were compared to earlier hot wire measurements and large differences in the normal turbulence intensity and the shear stress were found. These differences can be attributed to high turbulence intensity effects on the hot-wires. Received: 17 October 1996 / Accepted: 8 December 1997     

The laminar hole pressure for Newtonian fluids

For flows with wall turbulence the hole pressure, P _H , was shown empirically by Franklin and Wallace (J Fluid Mech, 42, 33–48, 1970) to depend solely on R ₊, the Reynolds number constructed from the friction velocity and the hole diameter b. Here this dependence is extended to the laminar regime by numerical simulation of a Newtonian fluid flowing in a plane channel (gap H) with a deep tap hole on one wall. Calculated hole pressures are in good agreement with experimental values, and for two hole sizes are well represented by: (P _H −P _HS )/τ _w = √(k ² + c ² R ₊²)−k, where the Stokes hole pressure P _HS /τ _w = s (b/H)³, k, c, s are fitted constants, and τ _w is the wall shear stress.     

Rheo-dielectric behavior of low molecular weight liquid crystal 2. Behavior of 8CB in nematic and smectic states

Rheo-dielectric behavior was examined for 4−4^′−n-octyl-cyanobiphenyl (8CB) having large dipoles parallel to its principal axis (in the direction of the C≡N bond). In the quiescent state at all temperatures (T) examined, orientational fluctuation of the 8CB molecules was observed as dielectric dispersions at characteristic frequencies ω_c>10⁶ s⁻¹. In the isotropic state at high T, no detectable changes of the complex dielectric constant ɛ^*(ω) were found under slow flow at shear rates ˙γ≫ω_c. In the nematic state at intermediate T, the terminal relaxation intensity of ɛ^*(ω) was decreased under such slow flow. In the smectic state at lower T, the flow effect became much less significant. These results were related to the flow-induced changes of the liquid crystalline textures in the nematic and smectic states, and the differences of the rheo-dielectric behavior in these states are discussed in relation to a difference of the symmetry of molecular arrangements in the nematic and smectic textures. Received: 1 October 1998 Accepted: 13 January 1999