Novel constrained beta-turn dipeptide mimetics, 8-phenyl thiaindolizidinone amino acids 3, have been synthesized stereoselectively and incorporated into Leu-enkephalin peptides as a replacement of dipeptide Gly3-Phe4 to afford four individual isomers of Leu-enkephalin analogues 6. 相似文献
In this paper, a generalized strong vector quasi-equilibrium problem with set-valued mapping and domination structure is presented, and under the condition of cone-continuity, existence of solutions and the compactness of solution set are established. As applications, existence of solutions for strong vector F-implicit variational inequality problem and strong vector F-implicit complementarity problem is derived, and Khan’s main results are corrected. 相似文献
Initial‐boundary value problems for the coupled nonlinear Schrödinger equation on the half‐line are investigated via the Fokas method. It is shown that the solution can be expressed in terms of the unique solution of a matrix Riemann–Hilbert problem formulated in the complex k‐plane, whose jump matrix is defined in terms of the matrix spectral functions and that depend on the initial data and all boundary values, respectively. If there exist spectral functions satisfying the global relation, it can be proved that the function defined by the above Riemann–Hilbert problem solves the coupled nonlinear Schrödinger equation and agrees with the prescribed initial and boundary values. The most challenging problem in the implementation of this method is to characterize the unknown boundary values that appear in the spectral function . For a particular class of boundary conditions so‐called linearizable boundary conditions, it is possible to compute the spectral function in terms of and given boundary conditions by using the algebraic manipulation of the global relation. For the general case of boundary conditions, an effective characterization of the unknown boundary values can be obtained by employing perturbation expansion. 相似文献
Metabolic profiles from human urine reveal the significant difference of carnitine and acylcarnitines levels between non‐small cell lung carcinoma patients and healthy controls. Urine samples from cancer patients and healthy individuals were assayed in this metabolomic study using ultra high performance liquid chromatography coupled to quadrupole time‐of‐flight mass spectrometry. The data were normalized by the sum of all intensities and creatinine calibration, respectively, before orthogonal partial least squares discriminant analysis. Twenty differential metabolites were identified based on standard compounds or tandem mass spectrometry fragments. Among them, some medium‐/long‐chain acylcarnitines, for example, cis‐3,4‐methylene heptanoylcarnitine, were found to be downregulated while carnitine was upregulated in urine samples from the cancer group compared to the control group. Receiver operating characteristic analysis of the two groups showed that the area under curve for the combination of carnitine and 11 selected acylcarnitines was 0.958. This study suggests that the developed carnitine and acylcarnitines profiling method has the potential to be used for screening non‐small cell lung carcinoma. 相似文献
In this study, a novel quad-stable energy harvester (QEH) is developed, in which its coordinates of equilibrium points can be user-defined like programming. This programmable feature distinguishes the proposed QEH from all reported magnet-type or buckling-type vibration energy harvesters. It has the advantage that it is easy to develop a high-performance QEH by appropriately programming these coordinate points and customizing a personalized QEH for different vibration environments. The dynamic model is established by the Ritz method and the Lagrange equation. The analytical steady periodic response is obtained by the average method. When the excitation acceleration is 2 m/s2, the peak power is 575 μW at 8.5 Hz. Also, the influence of the coordinate arrangement of the equilibrium points on the energy harvesting performance is studied. A formula that can quickly determine the equilibrium point coordinates is given, and the QEH designed according to this formula has superior performance. At last, the performance of the designed QEH is compared with other reported vibration energy harvesters. It shows that the QEH has a high average output power (287 μW), high normalized power density (59.8 μW/cm3/g2), and wide operating frequency range (8.4 Hz) among these harvesters.