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21.
Marimuthu M Kandasamy K Ahn CG Sung GY Kim MG Kim S 《Analytical and bioanalytical chemistry》2011,401(5):1645-1653
Complementary metal oxide semiconductor (CMOS)-based image sensors have received increased attention owing to the possibility
of incorporating them into portable diagnostic devices. The present research examined the efficiency and sensitivity of a
CMOS image sensor for the detection of antigen–antibody interactions involving interferon gamma protein without the aid of
expensive instruments. The highest detection sensitivity of about 1 fg/ml primary antibody was achieved simply by a transmission
mechanism. When photons are prevented from hitting the sensor surface, a reduction in digital output occurs in which the number
of photons hitting the sensor surface is approximately proportional to the digital number. Nanoscale variation in substrate
thickness after protein binding can be detected with high sensitivity by the CMOS image sensor. Therefore, this technique
can be easily applied to smartphones or any clinical diagnostic devices for the detection of several biological entities,
with high impact on the development of point-of-care applications. 相似文献
22.
Z-scan studies on porphyrin derivative 总被引:2,自引:0,他引:2
K. Kandasamy K. Divakar Rao Rekha Deshpande P.N. Puntambekar Bhanu P. Singh Shankar J. Shetty T.S. Srivastava 《Applied physics. B, Lasers and optics》1997,64(4):479-484
Received: 10 January 1996 / Revised version: 15 June 1996 相似文献
23.
Measurements of the work functions of films of TiHx and ZrHx during the FCC/FCT transition have given the change of Fermi level between these two phases of the hydrides. The results agree with modern calculations of the band structures of these hydrides. 相似文献
24.
25.
Vadapalli Chandrasekhar Kandasamy Gopal Loganathan Nagarajan Palani Sasikumar Pakkirisamy Thilagar 《Journal of Chemical Sciences》2006,118(6):455-462
Phosphonate ligands, [RPO3]2-, are extremely versatile in the assembly of multi-tin and multi-copper architectures. We have used organostannoxane cores
for supporting multi-ferrocene and multi-porphyrin peripheries. The copper-metalated multi-porphyrin compound is an excellent
reagent for facile cleavage of DNA, even in the absence of a co-oxidant. Reaction oft-BuPO3H2 with Cu(C104)2. 6H2O in the presence of 2-pyridylpyrazole (2-Pypz) leads to the synthesis of a decanuclear copper (II) assembly. 相似文献
26.
27.
Zacharias Kohl Martin Regensburger Robert Aigner Mahesh Kandasamy Beate Winner Ludwig Aigner Jürgen Winkler 《BMC neuroscience》2010,11(1):114
Background
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder linked to expanded CAG-triplet nucleotide repeats within the huntingtin gene. Intracellular huntingtin aggregates are present in neurons of distinct brain areas, among them regions of adult neurogenesis including the hippocampus and the subventricular zone/olfactory bulb system. Previously, reduced hippocampal neurogenesis has been detected in transgenic rodent models of HD. Therefore, we hypothesized that mutant huntingtin also affects newly generated neurons derived from the subventricular zone of adult R6/2 HD mice. 相似文献28.
A. Kandasamy R. Mohan M. Lydia Caroline S. Vasudevan 《Crystal Research and Technology》2008,43(2):186-192
Nucleation parameters such as solubility, induction period, interfacial energy and metastable zone width have been investigated for the aqueous solution growth of a semi‐organic nonlinear optical (NLO) material of L‐Proline cadmium chloride monohydrate (L‐PCCM) single crystal. Metastable zone width and induction period values were determined experimentally in order to optimize the growth parameters. The grown crystals are transparent (dimensions: 16 x 8 x 5 mm3) and characterized by powder X‐Ray Diffraction and dielectric studies. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
29.
Swati Chauhan Priyanka Chaudhary Adesh Kumar Singh Pratibha Verma Vandana Srivastava Jeyakumar Kandasamy 《Tetrahedron letters》2018,59(3):272-276
A simple and efficient method for the dimerization of primary thioamides into 1,2,4-thiadiazoles using tert-butyl nitrite is described. The optimized condition was also found to be suitable for the dimerization of benzoselenoamides into 1,2,4-selenadiazoles. All the reactions proceed smoothly at room temperature and gave the desired products in excellent yields in a short span of time. 相似文献
30.
To understand the origin of transmembrane potentials, formation of transient pores, and the movement of anions and cations across lipid membranes, we have performed systematic atomistic molecular dynamics simulations of palmitoyl-oleoyl-phosphatidylcholine (POPC) lipids. A double bilayer setup was employed and different transmembrane potentials were generated by varying the anion (Cl-) and cation (Na+) concentrations in the two water compartments. A transmembrane potential of approximately 350 mV was thereby generated per bilayer for a unit charge imbalance. For transmembrane potential differences of up to approximately 1.4 V, the bilayers were stable, over the time scale of the simulations (10-50 ns). At larger imposed potential differences, one of the two bilayers breaks down through formation of a water pore, leading to both anion and cation translocations through the pore. The anions typically have a short residence time inside the pore, while the cations show a wider range of residence times depending on whether they bind to a lipid molecule or not. Over the time scale of the simulations, we do not observe the discharge of the entire potential difference, nor do we observe pore closing, although we observe that the size of the pore decreases as more ions translocate. We also observed a rare lipid flip-flop, in which a lipid molecule translocated from one bilayer leaflet to the opposite leaflet, assisted by the water pore. 相似文献