Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington's disease |
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| Authors: | Zacharias Kohl Martin Regensburger Robert Aigner Mahesh Kandasamy Beate Winner Ludwig Aigner Jürgen Winkler |
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| Affiliation: | (1) Division of Molecular Neurology, University Hospital Erlangen, Erlangen, Germany;(2) Department of Neurology, University of Regensburg, Regensburg, Germany;(3) Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria;(4) Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, USA |
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| Abstract: | Background Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder linked to expanded CAG-triplet nucleotide repeats within the huntingtin gene. Intracellular huntingtin aggregates are present in neurons of distinct brain areas, among them regions of adult neurogenesis including the hippocampus and the subventricular zone/olfactory bulb system. Previously, reduced hippocampal neurogenesis has been detected in transgenic rodent models of HD. Therefore, we hypothesized that mutant huntingtin also affects newly generated neurons derived from the subventricular zone of adult R6/2 HD mice. |
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