| 可生物降解聚[(对羟基苯甲酸甲酯/甘氨酸乙酯)膦腈]的合成及其体外降解 |
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| 引用本文： | 黄小彬,陈奎永,李静,郑元俐,江金贵,唐小真.可生物降解聚[(对羟基苯甲酸甲酯/甘氨酸乙酯)膦腈]的合成及其体外降解[J].中国科学:化学,2011(3):485-490. |
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| 作者姓名： | 黄小彬 陈奎永 李静 郑元俐 江金贵 唐小真 |
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| 作者单位： | 上海交通大学化学化工学院;上海交通大学医学院附属第九人民医院口腔修复科上海市口腔医学重点实验室;上海交通大学金属基复合材料国家重点实验室; |
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| 摘 要： | 以PCl5和NH4Cl为原料,利用一锅法制备了聚二氯膦腈,通过两步亲核取代反应,分别以甘氨酸乙酯和对羟基苯甲酸甲酯为亲核试剂,合成了混合取代可生物降解聚(对羟基苯甲酸甲酯/甘氨酸乙酯)膦腈].用核磁共振波谱及红外光谱等对产物结构进行了表征.研究了甘氨酸乙酯和对羟基苯甲酸甲酯的比例及外界环境对所制备的聚膦腈降解性能的影响,并进行了体外降解实验.研究结果表明,通过改变甘氨酸乙酯和对羟基苯甲酸甲酯的比例,可获得一种降解速率可调节的生物降解膦腈聚合物.
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| 关 键 词： | 聚膦腈 可生物降解 对羟基苯甲酸甲酯 甘氨酸乙酯 |
Synthesis of biodegradable poly(methylparaben/glycine ethyl ester) phosphazene and further research of its degradation in vitro |
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| HUANG XiaoBin,CHEN KuiYong,LI Jing,ZHENG YuanLi,JIANG JinGui,＆ TANG XiaoZhen.Synthesis of biodegradable poly(methylparaben/glycine ethyl ester) phosphazene and further research of its degradation in vitro[J].Scientia Sinica Chimica,2011(3):485-490. |
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| Authors: | HUANG XiaoBin CHEN KuiYong LI Jing ZHENG YuanLi JIANG JinGui ＆ TANG XiaoZhen |
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| Institution: | 1,3 1 College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China 2 Department of Prothodontics, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China 3 State Key Laboratory of Metallic Matrix Composite Material; Shanghai Jiao Tong University, Shanghai 200240, China |
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| Abstract: | Polydichlorophosphazene (PDCP) was synthesized from PCl5 and NH4Cl via a one-pot approach, and then further reacted with glycine ethyl ester and methylparaben via a two-step nucleophilic substitution approach to give poly(methylparaben/glycine ethyl ester)]phosphazene (PMGP), which was a kind of mix-substituted biodegradable polymer. NMR and FT-IR were used to characterize its structure. A series of experiments were conducted to study the effects of the ratio of methylparaben to glycine ethyl ester and the... |
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| Keywords: | polyphosphazene biodegradable methyl parahydroxybenzoats glycine ethyl ester |
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