Sterols from the Stems of Momordica charantia |
| |
| Authors: | Yun‐Wen Liao Chiy‐Rong Chen Jue‐Liang Hsu Hsueh‐Ling Cheng Wen‐Ling Shih Yueh‐Hsiung Kuo Tzou‐Chi Huang Chi‐I Chang |
| |
| Institution: | 1. Department of Food Science, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan, R.O.C.;2. Department of Life Science, National Taitung University, Taitung 95002, Taiwan, R.O.C.;3. Graduate Institute of Biotechnology, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan, R.O.C.;4. Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University, Taichung 40402, Taiwan, R.O.C. |
| |
| Abstract: | A new sterol, 5α,6α‐epoxy‐3β‐hydroxy‐(22E,24R)‐ergosta‐8,22‐dien‐7‐one ( 1 ), together with eight known sterols, 5α,6α‐epoxy‐(22E,24R)‐ergosta‐8,22‐diene‐3β,7α‐diol ( 2 ), 5α,6α‐epoxy‐(22E,24R)‐ergosta‐8,22‐diene‐3β,7β‐diol ( 3 ), 5α,6α‐epoxy‐(22E,24R)‐ergosta‐8(14),22‐diene‐3β,7α‐diol ( 4 ), 3β‐hydroxy‐(22E,24R)‐ergosta‐5,8,22‐trien‐7‐one ( 5 ), ergosterol peroxide ( 6 ), clerosterol ( 7 ), decortinol ( 8 ), and decortinone ( 9 ), were isolated from the stems of Momordica charantia. Their structures were elucidated by mean of extensive spectroscopic methods, including 1H, 13C, 2D‐NMR and HR‐EI‐MS, as well as comparison with the literature data. Compounds 1 , 4 , 5 , 8 , and 91 were not cytotoxic against the SK‐Hep 1 cell line. |
| |
| Keywords: | Momordica charantia Cucurbitaceae Stem Sterol Ergostane |
|
|
