| CHEMOTHERAPEUTIC POLYMER ⅩⅦ. THE SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYPHOSPHATES CONTAINING BOTH NUCLEIC ACID BASE AND NITROGEN MUSTARD |
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| 引用本文： | 周念恩,陈衢生,卓仁禧.CHEMOTHERAPEUTIC POLYMER ⅩⅦ. THE SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYPHOSPHATES CONTAINING BOTH NUCLEIC ACID BASE AND NITROGEN MUSTARD[J].高分子科学,1986,0(4):316-321. |
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| 作者姓名： | 周念恩 陈衢生 卓仁禧 |
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| 作者单位： | Department of Chemistry，Wuhan University，Wuhan，Department of Chemistry，Wuhan University，Wuhan，Department of Chemistry，Wuhan University，Wuhan |
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| 摘 要： | Seven new polyphosphates containing both nucleic acid base and nitrogen mustard were preparedby reacting the monomers, i.e. 1,3-dihydroxyalkyl-5-fluorouracil(II_(a.,b, g)), 1,3-dihydroxyalkyluracil(II_(c,d)) and 1, 3-dihydroxyalkylthymine (II_(e,f)) with W, N,N-bis(2-chloroethyl)phosphoramide dichlo-ride (I). The monomers and polymers were characterized by ~1H-NMR, IR spectra and elementalanalysis. All of the polymers obtained are soluble in water. The antitumor activity of some of thesepolymers were tested against Ehrlish Ascites in mice. The results showed that the polyphosphatescontaining both 5-fluorouracil and nitrogen mustard exhibit lower toxicity and higher antitumor ac-tivity. The inhibition ratio of the polymer (III_a) is 66%.
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| 收稿时间： | 1985-04-23 |
CHEMOTHERAPEUTIC POLYMER ⅩⅦ. THE SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYPHOSPHATES CONTAINING BOTH NUCLEIC ACID BASE AND NITROGEN MUSTARD |
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| ZHOU Nianen,CHEN Qusheng,ZHUO Renxi.CHEMOTHERAPEUTIC POLYMER ⅩⅦ. THE SYNTHESIS AND ANTITUMOR ACTIVITY OF POLYPHOSPHATES CONTAINING BOTH NUCLEIC ACID BASE AND NITROGEN MUSTARD[J].Chinese Journal of Polymer Science,1986,0(4):316-321. |
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| Authors: | ZHOU Nianen CHEN Qusheng ZHUO Renxi |
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| Institution: | Department of Chemistry; Wuhan University. Wuhan |
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| Abstract: | Seven new polyphosphates containing both nucleic acid base and nitrogen mustard were preparedby reacting the monomers, i.e. 1,3-dihydroxyalkyl-5-fluorouracil(IIa.,b, g), 1,3-dihydroxyalkyluracil(IIc,d) and 1, 3-dihydroxyalkylthymine (IIe,f) with W, N,N-bis(2-chloroethyl)phosphoramide dichlo-ride (I). The monomers and polymers were characterized by 1H-NMR, IR spectra and elementalanalysis. All of the polymers obtained are soluble in water. The antitumor activity of some of thesepolymers were tested against Ehrlish Ascites in mice.The results showed that the polyphosphates containing both 5-fluorouracil and nitrogen mustard exhibit lower toxicity and higher antitumor activity.The inhibition ratio of the polymer(Ⅲa) is 66%. |
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