| SURFACE MODIFICATION OF BLEND FILMS COMPOSED OF SILK FIBROIN AND POLY（ETHYLENE GLYCOL） MACROMER AND THEIR IN VITRO ANTITHROMBOGENICITY |
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| 作者姓名： | Hua-xinSun SongWang He-sunZhu. |
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| 作者单位： | ResearchCenterofMaterials,Beij＇ingInstituteofTechnology,Beij＇ing100081,China |
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| 基金项目： | 国家重点基础研究发展计划(973计划)
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国家高技术研究发展计划(863计划) |
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| 摘 要： | In order to improve the blood compatibility of silk fibroin (SF), poly(ethylene glycol) macromer (PEGM) in different amounts was added to the SF film to incorporate C=C group into the surface of blend films which were then modified by SO2 gas plasma treatment. ATR-FITR and XPS were used to analyze the chemical change which had occurred on the film‘s surface. When the content of sulfur on the surface of blend films surpasses 1.59%, the antithrombogenicity of plasma treated films increases remarkably due to surface sulfonation. This result implies that SF with blend of PEGM after SO2 plasma treatment have potential use for making blood-contacting biomaterials.
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| 关 键 词： | 表面修饰 聚（乙烯乙二醇） 血浆 抗凝血酶原活性 丝纤蛋白 |
| 收稿时间： | 2003-10-09 |
| 修稿时间： | 2003-12-29 |
SURFACE MODIFICATION OF BLEND FILMS COMPOSED OF SILK FIBROIN AND POLY(ETHYLENE GLYCOL) MACROMER AND THEIR IN VITRO ANTITHROMBOGENICITY* |
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| Hua-xinSun SongWang He-sunZhu..SURFACE MODIFICATION OF BLEND FILMS COMPOSED OF SILK FIBROIN AND POLY(ETHYLENE GLYCOL) MACROMER AND THEIR IN VITRO ANTITHROMBOGENICITY*[J].Chinese Journal of Polymer Science,2004,0(4):399-403. |
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| Authors: | Hua-xin Sun Song Wang He-sun Zhu |
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| Institution: | Research Center of Materials; Beijing Institute of Technology; Beijing 100081; China |
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| Abstract: | In order to improve the blood compatibility of silk fibroin (SF), poly(ethylene glycol) macromer (PEGM) in different amounts was added to the SF film to incorporate C=C group into the surface of blend films which were then modified by SO2 gas plasma treatment. ATR-FITR and XPS were used to analyze the chemical change which had occurred on the film's surface. When the content of sulfur on the surface of blend films surpasses 1.59%, the antithrombogenicity of plasma treated films increases remarkably due to surface sulfonation. This result implies that SF with blend of PEGM after SO2 plasma treatment have potential use for making blood-contacting biomaterials. |
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| Keywords: | Silk fibroin Poly(ethylene glycol) macromer Plasma Antithrombogenicity POLY SILK FIBROIN BLEND FILMS MODIFICATION SURFACE GLYCOL ETHYLENE ANTITHROMBOGENICITY IN VITRO result blend films potential making biomaterials antithrombogenicity plasma treatment surface sulfonation content sulfur used |
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