| Voltammetric studies on the interaction of amikacin with methyl blue and its analytical application |
| |
| 作者姓名： | Xue Liang Wang Zhang Yu Yu Kui Jiao |
| |
| 作者单位： | a，b，* |
| |
| 摘 要： | A new method to determine the concentration of amikacin(AMK)using methyl blue(MB)as electrochemical probe was developed in this paper.In pH 4.5 Britton-Robinson(B-R)buffer solution,the MB reacted with AMK to form ion association complexes,which led to the reductive peak current of MB at-0.275 V(versus SCE)to decrease,and the decreases were linear with the concentration of AMK in the range of 1.0-60.0 mg/L,the regression of equation isΔIp(nA)=-8.48 102.36c(mg/L), correlation coefficientγis 0.997.The conditions for determining the concentration of AMK using linear sweep voltammetry(SLV) were optimized.The method was used to determine the content of amikacin commercially available with satisfactory results.
|
| 关 键 词： | 氨基羟丁基卡那霉素A 甲基蓝 相互作用 伏安法 药物含量分析 应用 |
| 收稿时间： | 2006-06-02 |
Voltammetric studies on the interaction of amikacin with methyl blue and its analytical application |
| |
| Xue Liang Wang Zhang Yu Yu Kui Jiao.Voltammetric studies on the interaction of amikacin with methyl blue and its analytical application[J].Chinese Chemical Letters,2007,18(1):94-96. |
| |
| Authors: | Xue Liang Wang Zhang Yu Yu Kui Jiao |
| |
| Institution: | 1. Department of Chemistry and Chemical Engineering, Heze University, Heze 274015, China;2. College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China |
| |
| Abstract: | A new method to determine the concentration of amikacin (AMK) using methyl blue (MB) as electrochemical probe was developed in this paper. In pH 4.5 Britton–Robinson (B–R) buffer solution, the MB reacted with AMK to form ion association complexes, which led to the reductive peak current of MB at −0.275 V (versus SCE) to decrease, and the decreases were linear with the concentration of AMK in the range of 1.0–60.0 mg/L, the regression of equation is ΔIp (nA) = −8.48 + 102.36c (mg/L), correlation coefficient γ is 0.997. The conditions for determining the concentration of AMK using linear sweep voltammetry (SLV) were optimized. The method was used to determine the content of amikacin commercially available with satisfactory results. |
| |
| Keywords: | Methyl blue Amikacin Voltammetry |
| 本文献已被 CNKI 维普 万方数据 ScienceDirect 等数据库收录！ |
