| A New Method of Separation of Four Benzodiazepines by RP-CEC |
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| 作者姓名： | JinLanZHANG TongHuiZHOU |
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| 作者单位： | InstituteofMateriaMedica,ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Beijing100050 |
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| 摘 要： | A new method to separate diazepam, nitrazepam, estazolam, alprazolam was established on both C18 and C8 CEC columns. The influence of separation voltage, Tris concentration, column temperature and the percentage of acetonitrile on the resolution and retention behavior of four benzodiazepines was investigated. The results showed that the percentage of acetonitrile had the largest effect on the resolution and retention behavior of the four benzodiazepines. Other separation conditions had also effects on the resolution and retention behavior, but smaller than the concentration of acetonitrile. Optimum separation conditions were obtained to separate four benzodiazepines on C18 and C8 CEC columns.
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| 关 键 词： | 苯二氮卓 毛细管电色谱分析 安定 硝基安定 三唑氯安定 阿普唑仑 |
A New Method of Separation of Four Benzodiazepines by RP-CEC |
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| JinLanZHANG TongHuiZHOU.A New Method of Separation of Four Benzodiazepines by RP-CEC[J].Chinese Chemical Letters,2004,15(8):935-938. |
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| Authors: | Jin Lan ZHANG Tong Hui ZHOU
Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical
College Beijing |
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| Institution: | Jin Lan ZHANG,Tong Hui ZHOU
Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical
College,Beijing 100050 |
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| Abstract: | A new method to separate diazepam, nitrazepam, estazolam, alprazolam was established on both C18 and C8 CEC columns. The influence of separation voltage, Tris concentration, column temperature and the percentage of acetonitrile on the resolution and retention behavior of four benzodiazepines was investigated. The results showed that the percentage of acetonitrile had the largest effect on the resolution and retention behavior of the four benzodiazepines. Other separation conditions had also effects on the resolution and retention behavior, but smaller than the concentration of acetonitrile. Optimum separation conditions were obtained to separate four benzodiazepines on C18 and C8 CEC columns. |
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| Keywords: | Capillary electrochromatography diazepam nitrazepam estazolam alprazolam |
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