Fabrication linalool-functionalized hollow mesoporous silica spheres nanoparticles for efficiently enhance bactericidal activity |
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| Institution: | 1. College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China;2. College of Food Science and Technology, Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai), Ministry of Agriculture and Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai Ocean University, Shanghai 201306, China;1. The State Key Laboratory of Molecular Engineering of Polymers, Department of Chemistry, Fudan University, Shanghai 200433, China;2. Department of Physics & Department of Chemistry, College of Science, Shanghai University, Shanghai 200444, China;1. College of Food Science and Technology, Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai), Ministry of Agriculture and Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation Shanghai Ocean University, Shanghai 201306, China;2. School of Basic Medicine, Xinxiang Medical University, Xinxiang 453003, China;3. College of Bioengineering and Food, Hubei University of Technology, Wuhan 430068, China;1. College of Food Science and Technology, Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai), Ministry of Agriculture and Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation Shanghai Ocean University, Shanghai 201306, China;2. Shanghai Agricultural Product Quality and Safety Center, Shanghai 201306, China;3. Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia;4. Department of Chemistry, Fudan University Shanghai 200433, China;5. State Key Lab of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China;1. NEST Lab, Department of Chemistry, College of Science, Shanghai University, Shanghai 200444, China;2. Coll Food Sci & Technol, Shanghai Ocean Univ, Shanghai 201306, China;3. State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China;1. Chemical Biology Lab (ASK-II), School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur-613401, Tamilnadu, India;2. Biofilm Biology Lab, School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur-613401, Tamilnadu, India |
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| Abstract: | To develop a novel food preservation technology for efficiently enhance bactericidal activity in a long term, hollow mesoporous silica spheres (HMSS) with regular nanostructures were applied to encapsulate natural organic antimicrobial agents. The chemical structures, morphologies and thermal stabilities of linalool, HMSS and linalool-functionalized hollow mesoporous silica spheres (L-HMSS) nanoparticles were evaluated by polarimeter, field emission scanning electron microscope (FE-SEM), transmission electron microscope (TEM), fourier transform infrared (FT-IR), thermal gravimetric analyzer (TGA), nitrogen adsorption-desorption, zeta potential and small angle X-ray diffraction (SXRD). The results show that the linalool was successfully introduced into the cavities of HMSS, and the inorganic host exhibited a high loading capacity of about 1500 mg/g. In addition, after 48 h of incubation, the minimum bactericidal concentrations (MBC) of L-HMSS against Escherichia coli (E. coli), Salmonella enterica (S. enterica) and Staphylococcus aureus (S. aureus), Listeria monocytogenes (L. monocytogenes) were decreased to be 4 (< 5) mg/mL and 8 (< 10) mg/mL, respectively. These results revealed linalool-functionalized hollow mesoporous spheres could efficiently improve the bactericidal activities of the organic component. Furthermore, SEM images clearly showed that L-HMSS indeed had an extremely inhibitory effect against gram-negative (E. coli) and gram-positive (S. aureus) by breaking the structure of the cell membrane. This research is of great significance in the application of linalool in nano-delivery system as well as food industry. |
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| Keywords: | Linalool Hollow mesoporous silica spheres Encapsulation Bactericidal activity Antimicrobial mechanism |
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