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A visible-light-promoted cross-dehydrogenative-coupling reaction of N-arylglycine esters with imidazo[1,2-a]pyridines
Authors:Zhi-Qiang Zhu  Li-Jin Xiao  Chun-Cheng Zhou  Han-Lin Song  Zong-Bo Xie  Zhang-Gao Le
Institution:1. State Key Laboratory Breeding Base of Nuclear Resources and Environment, East China University of Technology, Nanchang 330013, PR China;2. School of Chemistry, Biology and Material Science, East China University of Technology, Nanchang 330013, PR China
Abstract:A mild and convenient visible-light-promoted cross-dehydrogenative-coupling reaction between N-arylglycine esters and imidazo1,2-a]pyridines for the construction of C/>C bond was developed. A range of <em>N</em>-arylglycine esters and imidazo1,2-<em>a</em>]pyridines were able to undergo the CDC reaction readily to afford α-heteroaryl substituted α-amino acid derivatives in good to excellent yields. A tentative mechanism for the photoredox reaction was also proposed. Importantly, the use of copper(II) salt as the sole catalyst in this visible-light-promoted transformation makes this reaction sustainable and practical.</td>
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Keywords:Copper  Visible light  Cross-dehydrogenative-coupling  Glycine ester  Corresponding authors at: State Key Laboratory Breeding Base of Nuclear Resources and Environment  and School of Chemistry  Biology and Material Science  East China University of Technology  Nanchang 330013  PR China  
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