| 生理液中血卟啉溶液状态的光谱研究 |
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| 引用本文： | 何锡文,冯喜增,张贵珠,杨万龙,于贵英,史慧明.生理液中血卟啉溶液状态的光谱研究[J].高等学校化学学报,1994,15(4):503. |
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| 作者姓名： | 何锡文 冯喜增 张贵珠 杨万龙 于贵英 史慧明 |
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| 作者单位： | 南开大学化学系, 天津, 300071 |
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| 摘 要： | 本文通过对血卟啉在生理条件下(pH=7.2,I=0.5mol/LNaCl)水溶液中的光谱变化研究,探讨了其在溶液中的聚集状态。应用Kasha理论推算出血卟啉二聚体的面-面间距离为0.528nm,面间夹角为20°,平衡常数为2.85×10-6.研究了在光作用下,血卟啉-人血清白蛋白溶液体系的光谱特性,讨论了光谱特性与血卟啉在癌瘤光化学治疗机制间的关系。
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| 关 键 词： | 血卟啉 人血清白蛋白 溶液状态 光化学机理 |
| 收稿时间： | 1993-05-04 |
Studies on the State of Hematoporphyrin(HP) in Physiological Condition Solution |
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| HE Xi-WEn, FENG Xi-Zeng, ZHANG Gui-Zhu, YANG Wan-Long,YU Gui-Ying, SHI Hui-Ming.Studies on the State of Hematoporphyrin(HP) in Physiological Condition Solution[J].Chemical Research In Chinese Universities,1994,15(4):503. |
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| Authors: | HE Xi-WEn FENG Xi-Zeng ZHANG Gui-Zhu YANG Wan-Long YU Gui-Ying SHI Hui-Ming |
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| Institution: | Department of Chemistry, Nankai University, Tianjin, 300071 |
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| Abstract: | The polymeric state of hematoporphyrin (HP) under physiological conditions and in aqueous solution has been studied by spectrum analysis.From application of Kasha's theory on the difference spectrum between HPmonomer and dimer, we have estimated that the distance between xanthene planes of HPis 0.528 nm and these planes form the cross angle 20°in dimer molecules (Fig.3).The relationship between the energy transmission of HPHSAand the solution state is discussed.The relationship between the photochemical mechanism of curing malignant tumours and the fluorescence character of HP-HSAis discussed. |
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| Keywords: | Hematoporphyrin(HP) Human serum albumin (HSA) Solution state Photochemical mechanism |
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