| 非螯合型手性双膦/钌催化的不对称氢化反应 |
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| 引用本文： | 李庆山,张玉华,殷元骐.非螯合型手性双膦/钌催化的不对称氢化反应[J].高等学校化学学报,2002,23(10):1936-1938. |
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| 作者姓名： | 李庆山 张玉华 殷元骐 |
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| 作者单位： | 1. 中国科学院兰州化学物理研究所, 兰州 730000;
2. 南开大学元素有机化学国家重点实验室, 天津 300071 |
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| 基金项目： | 国家自然科学基金 (批准号 :2 9873 0 61)资助 |
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| 摘 要： | 对RuCl3和手性双膦(2S,5S)-2,5-双-(二苯膦)-1,4∶3,6-双脱水-2,5-双去氧-L-艾杜醇(BDPI)催化的不对称氢化反应进行了研究,反应的转化率为100%,光学收率受双膦]/RuCl3]比值的影响较大.在α-乙酰胺基肉桂酸的催化氢化反应中,双膦]/RuCl3]=2.0时e.e.值最大,为68%;对衣糠酸的催化氢化,双膦]/RuCl3]=3时e.e.值最大,为92%.
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| 关 键 词： | 不对称氢化反应 手性双膦 RuCl3 |
| 文章编号： | 0251-0790(2002)10-1936-03 |
| 收稿时间： | 2001-09-14 |
Asymmetric Hydrogenation Catalyzed by RuCl3 and a Non-chelate Chiral Diphosphine |
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| LI Qing-Shan ,ZHANG Yu-Hua ,YIN Yuan-Qi.Asymmetric Hydrogenation Catalyzed by RuCl3 and a Non-chelate Chiral Diphosphine[J].Chemical Research In Chinese Universities,2002,23(10):1936-1938. |
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| Authors: | LI Qing-Shan ZHANG Yu-Hua YIN Yuan-Qi |
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| Institution: | 1. Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China;
2. State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China |
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| Abstract: | The asymmetric hydrogenation of α-acetaminocinnamic acid and itaconic acid catalyzed by RuCl3 and a non-chelate chiral diphosphine, (2S,5S)-2,5-bis(diphenylphosphine)-1,4∶3,6-dianhydro-2,5-dideoxy-L-iditol(BDPI), was studied. The conversion of both reaction was 100% and the enantiomer excess was strongly affected by the ratio of BDPI] to RuCl3]. The maximum of e.e. value was 68% and 92% for the asymmetric hydrogenation of α-acetaminocinnamic acid and itaconic acid, respectively. |
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| Keywords: | Asymmetric hydrogenation Chiral diphosphine RuCl 3 |
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