Evaluation of the Antioxidant Activity of Copper(II) Complexes containing Tris‐(hydroxymethyl)aminomethane (TRIS) Units |
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| Authors: | Cibele M Canabarro Joice Ceolin Josiéli D Siqueira Bernardo A Iglesias Gelson Manzoni de Oliveira Davi F Back Patrick T Campos |
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| Institution: | 1. Laboratório de Materiais Inorganicos, Department of Chemistry, Federal University of Santa Maria, UFSM, Santa Maria, RS, Brazil;2. +55‐55‐3220‐8031;3. Instituto Federal Sul‐Rio‐Grandense (IFSul), Campus Pelotas, RS, Brazil |
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| Abstract: | The structural analysis and the SOD‐like activity of CuII complexes (Cu)(C16H18N3O5)]ClO4 ( 1 ) and (Cu)4(C36H52N8O12)] ( 2 ) are described with ligands obtained from the condensation of picolinaldehyde and 2‐formylpyrrole with tris(hydroxymethyl)aminomethane (TRIS). Finally, complex 1 catalyzes the dismutation of superoxide efficiently with IC50 values in the range of 0.43 micromolar solution, evaluated through the inhibition of the photoreduction of nitro blue tetrazolium (NBT) (superoxide dismutase assay). |
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| Keywords: | Schiff bases Copper Superoxide dismutase SOD mimics |
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