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Thermal stability of metronidazole drug and tablets |
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| Authors: | de Souza Nadábia A B de Souza F S Basílio I D Medeiros Ana C D Oliveira E J Santos Ana F O Macwdo R O Macędo R O |
| Institution: | (1) Unidade de Desenvolvimento e Ensaios de Medicamentos/Laboratório de Tecnologia Farmacęutica-Universidade Federal da Paraíba-Campus I-Joăo Pessoa, Paraíba, ZIP 58059-900, Brasil;(2) Unidade de Desenvolvimento e Ensaio de Medicamentos, Laboratório de Tecnologia Farmacwutica, Universidade Federal da Paraíba, Campus I, Joăo, Pessoa, PB 58059-900, Brazil;(3) Unidade de Desenvolvimento e Ensaio de Medicamentos, Laboratório de Tecnologia Farmacwutica, Universidade Federal da Paraíba, Campus I, Joăo, Pessoa, PB 58059-900, Brazil;(4) Unidade de Desenvolvimento e Ensaios de Medicamentos/Laboratório de Tecnologia Farmacęutica-Universidade Federal da Paraíba-Campus I-Joăo, Pessoa Paraíba, ZIP 58059-900, Brasil |
| Abstract: | TG and DSC data were used to determine the thermal parameters of metronidazole drug and tablets. Three tablets A, B and C were analysed. The TG curves of metronidazole drug and tablets A and B displayed five and C four thermal decomposition processes, respectively. Analysis of the DSC data pointed to chemical interactions between metronidazole drug and the excipients of tablets, suggested by alterations in the melting point of metronidazole. The rate constants obtained from the isothermal TG data presents following sequence of the thermal stability: tablet A>tablet C>metronidazole drug>tablet B. This revised version was published online in July 2006 with corrections to the Cover Date. |
| Keywords: | dissolution rate constants DSC-photovisual pharmaceutical equivalence cimetidine metronidazole thermal analysis |
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