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A. C. D. de Medeiros N. A. B. de Cervantes A. P. B. Gomes R. O. Macêdo 《Journal of Thermal Analysis and Calorimetry》2001,64(2):745-750
TG and DSC data were used to determine the thermal parameters of prednisone drug and tablets. Two formulations of prednisone
20 mg were analysed in the form of tablets. The TG curves of prednisone drug and tablets A and B displayed six, eight and
seven thermal decomposition processes, respectively. Analysis of the DSC data pointed to chemical interactions between prednisone
drug and the excipients of tablets A and B, suggested by alterations in the melting temperature of prednisone. The analysis
revealed that prednisone drug is more stable than tablets A and B.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
2.
F. Santos de Souza A. P. Gomes Barreto R. O. Macêdo 《Journal of Thermal Analysis and Calorimetry》2001,64(2):739-743
The present work proposes evaluation of the gelatinization processes of starch by means of DSC coupled with a photovisual
system. The use of DSC, TG and DTA for a fast and efficient evaluation of the starch is suggested. The DSC curves of starch
gels with water contents of 20, 30, 40 and 50% (mass/v) exhibited different phase transitions, corresponding to the gelatinization
processes at the different water contents for the different lots. The DSC-photovisual system confirmed calorimetric behaviour
differences between the starch lots studied.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
3.
de Souza Nadábia A. B. de Souza F. S. Basílio I. D. Medeiros Ana C. D. Oliveira E. J. Santos Ana F. O. Macwdo R. O. Macędo R. O. 《Journal of Thermal Analysis and Calorimetry》2003,72(2):535-538
TG and DSC data were used to determine the thermal parameters of metronidazole drug and tablets. Three tablets A, B and C
were analysed. The TG curves of metronidazole drug and tablets A and B displayed five and C four thermal decomposition processes,
respectively. Analysis of the DSC data pointed to chemical interactions between metronidazole drug and the excipients of tablets,
suggested by alterations in the melting point of metronidazole. The rate constants obtained from the isothermal TG data presents
following sequence of the thermal stability: tablet A>tablet C>metronidazole drug>tablet B.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
4.
Thermal characterization is proposed as analytical methodology for the purity assay of lapachol, and for determination of
the quality parameters of capsules containing this molecule. The TG data revealed that lapachol is more stable in the presence
of adjuvants, showing the good quality of the formulation. The kinetic parameters obtained were lower for lapachol drug than
for the formulated lapachol. The DSC data demonstrated good compatibility between lapachol drug and the adjuvant in the formulated
lapachol, and did not reveal impurities such as secondary products of the isolation and recrystallization processes. The data
were confirmed by the DSC-photovisual findings.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
5.
Macêdo R. O. Gomes do Nascimento T. Veras J. W. E. 《Journal of Thermal Analysis and Calorimetry》2002,67(2):483-489
This study demonstrates the thermalanalysis applications in compatibility and stability studies of the propranolol binary
mixture sand tablets A and B. The propranolol binary mixtures were prepared in the laboratory and compared to the fully formulated
tablets using the thermogravimetric (TG) and calorimetric(DSC) methods. DSC of binary mixtures showed similar phase transition
to propranolol drug. The tablets phase transition decreased and there was no detectable significant interaction in propranolol–lactose
mixture and tablets. The DSC-photovisual test revealed an interaction similar to the Maillard reaction. The TG isothermal
study showed a difference in the profile between the drug and tablets due excipients quality and problems in manufacture process.
The kinetic parameters indicated a lower stability for the tablets than propranolol drug. The thermal techniques thermally
differentiated the propranolol preparations demonstrating the importance in the design development of pharmaceuticals solid-dosage
form.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
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