| 吡柔比星的伏安行为及其应用 |
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| 引用本文： | 胡劲波,欧阳波,黄清泉,李启隆.吡柔比星的伏安行为及其应用[J].分析试验室,2001,20(1):19-21. |
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| 作者姓名： | 胡劲波 欧阳波 黄清泉 李启隆 |
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| 作者单位： | 1. 北京师范大学化学系,
2. 中国药品生物制品检定所, |
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| 基金项目： | 国家自然科学基金!资助课题 ( 98750 0 3 |
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| 摘 要： | 吡柔比星在 0 .1 mol/L HAc- Na Ac缓冲溶液 (p H4.3)中 ,出现一灵敏的示波极谱导数还原峰 ,峰电位为 - 0 .39V(vs.SCE) ,峰电流与吡柔比星浓度在 2 .0× 1 0 -7～ 4.0× 1 0 -6mol/L范围内成正比。检出限为 1 .0× 1 0 -8mol/L。用于病人尿样的测定。用线性扫描和循环伏安法研究体系的性质。体系属具有吸附性的可逆过程。
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| 关 键 词： | 吡柔比星 单扫示波极谱 伏安行为 抗肿瘤药物 尿样 测定 |
| 文章编号： | 1000-0720(2001)01-0019-03 |
Study on Voltammetric Behavior of Pirarubicin and Its Determination |
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| HU Jing bo,OU Yang bo,LI Qi long.Study on Voltammetric Behavior of Pirarubicin and Its Determination[J].Chinese Journal of Analysis Laboratory,2001,20(1):19-21. |
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| Authors: | HU Jing bo OU Yang bo LI Qi long |
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| Abstract: | In a 0.1 mol/L HAc-NaAc (pH 4.3) buffer solution, a sensitive reduction peak of pirarubicin was obtained by single-sweep oscillopolarography. The peak potential is -0.39 V(vs.SCE). A linear relationship is held between the peak current and pirarubicin concentration in the range of 2.0×10-7～4.0×10-6 mol/L with detection limit of 1.0×10-8 mol/L. The method was applied to determination of trace pirarubicin in urine. The voltammetric behavior of the system was studied by linear sweep and cyclic voltammetry. The system belongs to the reversible process with adsorptive characteristics. |
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| Keywords: | Pirarubicin Single sweep oscillopolarography Voltammetric behavD |
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