Hydroxyapatite-poly(d,l-lactide) Nanografts. Synthesis and Characterization as Bone Cement Additives |
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| Authors: | Kristina L Goranova Anne Kathrine Kattenhj Sloth Overgaard Ivan Gitsov |
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| Institution: | 1.Department of Chemistry, State University of New York-ESF, Syracuse, NY 13210, USA; (K.L.G.); (A.K.K.S.O.);2.Coloplast, Holtedam 1-3, DK-3050 Humlebǽk, Denmark;3.The Michael M. Szwarc Polymer Research Institute, Syracuse, NY 13210, USA |
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| Abstract: | This paper reports the creation of hydroxyapatite/polyester nanografts by “graft-from” polymerization of d,l-lactide with Ca5(OH)(PO4)3]2 as the initiator and tin(II)-2-ethylhexanoate as the catalyst. Model polymerizations were performed with cyclooctanol as initiator to confirm the grafting on the surface of the hydroxyapatite nanocrystals. Polymers with the highest molecular mass (Mn) between 4250 Da (cyclooctanol) and 6100 Da (hydroxyapatite) were produced. In both cases the molecular mass distributions of the polymers formed were monomodal. The materials obtained were characterized by size-exclusion chromatography, NMR and FT-IR spectroscopy, and thermal methods. Their suitability as additives for commercial bone cement (Simplex P Speedset, Stryker Orthopaedics) has been confirmed by thermal analysis techniques and mechanical testing. The results obtained show that addition of the hydroxyapatite/ polyester nanografts improved both thermal and mechanical properties of the bone cement. |
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| Keywords: | hydroxyapatite lactide ring-opening polymerization polyesters biomaterials bone cement |
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