ε‐Caprolactone polymerization under air by the biocatalyst: Magnesium 2,6‐di‐tert‐butyl‐4‐methylphenoxide |
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| Authors: | Hsin‐Jou Fang Ping‐Shan Lai Jia‐Yun Chen Sodio C N Hsu Wei‐De Peng Siou‐Wei Ou Yi‐Chun Lai Yen‐Jen Chen Hsuan Chung Yun Chen Ta‐Chou Huang Bo‐Sheng Wu Hsuan‐Ying Chen |
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| Institution: | 1. Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, 100, Shih‐Chuan 1st Road, Kaohsiung, 80708, Kaohsiung, Taiwan, Republic of China;2. Department of Chemistry, National Chung Hsing University, Taichung 402, Taiwan, Republic of China |
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| Abstract: | This study investigated the synthesis of the biocatalyst, magnesium 2,6‐di‐tert‐butyl‐4‐methylphenoxide (Mg(BHT)2) complex, and the ring‐opening polymerization (ROP) of ε‐caprolactone (CL). The complex demonstrates high catalytic activity and controllable of molecular weight for the ROP of CL in tetrahydrofuran at room temperature, even when polymerization was performed under air. Before this study, the polymerization of CL had never been performed using a magnesium catalyst under air at room temperature. Various forms of alcohols with different purposes were also used as initiators with Mg(BHT)2. The results show that the magnesium complex acts as a perfect catalyst because of its high catalytic activity and control ability without any cytotoxicity in the polymerization of CL, making it suitable for biomedical applications. In addition, nanoparticle formation, cytotoxicity, and phototoxicity of tri‐2‐hydroxyethyl ester Ce6‐(CH2CH2OPCL)3] were also studied in this article and Ce6‐(CH2CH2OPCL)3 formed nanoparticle can act as a nanophotosensitizer for photodynamic therapy. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012 |
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| Keywords: | BHT biomaterials catalysts magnesium catalyst photodynamic therapy polyesters polylactone ring‐opening polymerization |
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