| 分散固相萃取-超高效液相色谱-串联质谱法测定鸡肝中磺胺类、喹诺酮类和苯并咪唑类药物及其代谢物的残留量 |
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| 引用本文： | 李锋格,苏敏,李晓岩,张洪霞,姚伟琴,窦辉,张万权.分散固相萃取-超高效液相色谱-串联质谱法测定鸡肝中磺胺类、喹诺酮类和苯并咪唑类药物及其代谢物的残留量[J].色谱,2011,29(2):120-125. |
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| 作者姓名： | 李锋格 苏敏 李晓岩 张洪霞 姚伟琴 窦辉 张万权 |
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| 作者单位： | 1. 新疆出入境检验检疫局技术中心, 新疆 乌鲁木齐 830063; 2. 新疆农业大学食品科学学院, 新疆 乌鲁木齐 830063 |
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| 基金项目： | 国家质量监督检验检疫总局科研项目(No.2007IK174) |
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| 摘 要： | 建立了一种分散固相萃取-超高效液相色谱-串联质谱(QuEChERS-UPLC-MS/MS)测定鸡肝中12种磺胺类、19种喹诺酮类和8种苯并咪唑类药物及其代谢物残留的分析方法。样品用1%乙酸-乙腈溶液提取,NH2吸附剂净化,正己烷脱脂。用Kromasil Eternity C18色谱柱(100 mm×2.1 mm, 2.5 μm)分离,以0.1%甲酸水溶液和甲醇为流动相进行梯度洗脱,电喷雾正离子(ESI+)模式电离,多反应监测模式检测,内标法定量。39种药物在5～100 μg/kg的空白添加浓度范围内线性良好(r2＞0.98);在10～50 μg/kg的添加水平范围内,平均回收率为72%～121%,相对标准偏差(RSD)为1.5%～23.4%; 39种药物的检出限(LOD)为5 μg/kg,定量限(LOQ)为10 μg/kg。该方法简便、快速、灵敏、准确,适合鸡肝中磺胺类、喹诺酮类和苯并咪唑类药物残留的确证和定量测定。
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| 关 键 词： | 分散固相萃取 超高效液相色谱-串联质谱法 磺胺 喹诺酮 苯并咪唑 鸡肝 |
| 收稿时间： | 2010-10-20 |
Determination of sulfonamides,quinolones, benzimidazoles and the metabolites of benzimidazoles in chicken livers by dispersive solid-phase extraction and ultra performance liquid chromatography-tandem mass spectrometry |
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| LI Fengge,SU Min,LI Xiaoyan,ZHANG Hongxia,YAO Weiqin,DOU Hui,ZHANG Wanquan.Determination of sulfonamides,quinolones, benzimidazoles and the metabolites of benzimidazoles in chicken livers by dispersive solid-phase extraction and ultra performance liquid chromatography-tandem mass spectrometry[J].Chinese Journal of Chromatography,2011,29(2):120-125. |
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| Authors: | LI Fengge SU Min LI Xiaoyan ZHANG Hongxia YAO Weiqin DOU Hui ZHANG Wanquan |
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| Institution: | 1. Technical Center of Xinjiang Entry-Exit Inspection and Quarantine Bureau, Urumqi 830063, China; 2. Food Science Institute, Xinjiang Agricultural University, Urumqi 830063, China |
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| Abstract: | A method for the determination of 12 sulfonamides,19 quinolones and 8 benzimidazoles and the metabolites of benzimidazoles in chicken livers by quick,easy,cheap,effective,rugged and safe(QuEChERS) extraction and ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) has been developed.The samples were extracted with 1% acetic acid-acetonitrile solution,cleaned up with amine(NH2) sorbent and defatted with n-hexane.The identification and quantification were achieved by using electrospray... |
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| Keywords: | dispersive solid-phase extraction ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) sulifonamides benzimidazoles quinolones chicken livers |
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