毛细管电泳分离过程的不可逆热力学模型及优化控制仿真

以非平衡热力学分离理论为框架,建立了毛细管电泳分离大系统的分离模型。以分离过程的操作电压U为控制量,以溶质体系的净分离熵S~S作为目标函数,通过对分离大系统的优化设计,得到了最优操作电压控制轨线U^*(t)。通过仿真,证明了分离大系统在此最优控制规律作用下,分离效果最好。

Irreversible thermodynamics in capillary electrophoresis separation process and optimal control

In this paper, on the basis of nonequilibrium thermodynamics separation theory, the separation model of capillary electrophoresis is established. Taking the operating voltage U as controllable parameter, the net separation entropy Ss of solute system as objective function, by optimal design of the separation big system, the optimizing control orbit U* (t )can be obtained. By simulation, the separation efficiency of the system under the control of U * (t) can reach to the expected results.