充蜡石墨支撑的季铵离子/己二酸混合双层膜上钙离子诱发的离子通道行为

以充蜡石墨电极作为新型支撑体，成功制备了一种季铵离子为内层（包括四丁 基铵TBA，十六烷基三甲基铵CTrMA），己二酸（HDA）为外层的新型自组装混合双 层膜，以循环伏安和电化学交流阻抗方法研究了膜的离子通道行为。该膜能够接受 Ca~(2+)的刺激作用而打开Fe(CN)_6]~(3-/4-)电极氧化还原的离子通道，撤走该 刺激离子则通道关闭。提出了混合双层膜的结构和离子通道作用的模型，指出外层 膜HDA分子可能具有V型和W型两种结构。

Calcium Ion Induced Ion Channel Behavior of Supported Hybrid Bilayer Membranes on a Waxed Graphite Electrode

A new kind of solid substrate, a wax-saturated graphite electrode (WGE), was used to support lipid layer membranes. On the surface of the WGE, a novel self-assembled hybrid bilayer membrane was fabricated by quaternary ammonium ions (including tetrabutyl amine-TBA, cetyl trimethylamine-CTrMA) with hexanedioic acid. From the cyclic voltammetry and ac impedance studies, the ion channel behavior of the supported hybrid bilayer membranes was characterized. In the presence of Ca 2+ as the stimulus and Fe~(CN) 6] 3-/4- as the marker ions, the ion channel effect and distinct channel current were observed. The channel was in closed state in the absence of Ca 2+. Two types of the structure of the hybrid bilayer membrane for the HDA-quaternary ammonium system were proposed: V and W types. This new membrane shows excellent stability and can be prepared easily.