New 19-oxygenated steroid from the South China Sea gorgonian Dichotella gemmacea |
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| Authors: | Fei Cao Hai-Yan Liu Jie Zhao Yu-Chun Fang |
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| Institution: | Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, Shandong, P.R. China |
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| Abstract: | A new 19-oxygenated steroid, 25-acetate-nebrosteroid K (1), and five known steroids (2–6), along with one known 19-hydroxy steroidal glycoside (7) were obtained from the gorgonian Dichotella gemmacea collected from the South China Sea. The structure and relative configuration of 1 were elucidated by using comprehensive spectroscopic data including NOESY spectra. Compound 1 represents the first example of 19-oxygenated steroid with a 19-oic acid methyl ester group isolated from gorgonians. All of the isolated compounds were evaluated for lethal activity to brine shrimp Artemia salina and cytotoxicity against A549 and HL-60 cell lines. Among them, 1 showed strong lethality towards A. salina. |
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| Keywords: | gorgonian Dichotella gemmacea 19-oxygenated steroid structure elucidation |
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