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| 暴露于环境烟气中的大鼠尿样代谢物分析 | |
| 引用本文： | 练文柳,任凤莲,何智慧,罗嘉,刘锋.暴露于环境烟气中的大鼠尿样代谢物分析[J].化学研究与应用,2011,23(4):502-508. |
| 作者姓名： | 练文柳 任凤莲 何智慧 罗嘉 刘锋 |
| 作者单位： | 1. 湖南中烟工业有限责任公司技术中心,湖南长沙410014;中南大学化学化工学院,湖南长沙410083 2. 中南大学化学化工学院,湖南长沙,410083 3. 湖南中烟工业有限责任公司技术中心,湖南长沙,410014 |
| 基金项目： | 湖南中烟工业有限责任公司重点项目 |
| 摘 要： | 4-(甲基亚硝胺基)-1-(3-吡啶基)-1-丁醇(NNAL)是烟草特有亚硝胺4-(甲基亚硝胺基)-1-(3-吡啶)-1-丁酮(NNK)在生物体内的一种代谢标记物,分析暴露于烟气中的生物体内NNAL的含量是研究卷烟烟气对生物体健康影响的有效手段.基于人体的个体差异性很大,本文以饲养的大鼠为研究对象,采用LC-MS/MS... |
| 关 键 词： | 代谢标记物 NNAL 尿样 环境烟气 |
Analysis of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in the rat urine exposed to environmental tobacco smoke |
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| LIAN Wen-liu,PEN Feng-lian,HE Zhi-hui,LUO Jia,LIU Feng.Analysis of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in the rat urine exposed to environmental tobacco smoke[J].Chemical Research and Application,2011,23(4):502-508. | |
| Authors: | LIAN Wen-liu PEN Feng-lian HE Zhi-hui LUO Jia LIU Feng |
| Institution: | LIAN Wen-liu1,2,REN Feng-lian2,HE Zhi-hui1,LUO Jia1,LIU Feng1(1.Research Center of China Tobacco Hunan Industrial Co.,Ltd.,Changsha 410014,China,2.School of Chemistry and Chemical Engineering,Central South University,Changsha 410083,China) |
| Abstract: | 4-methylnitrosamino)-1-(3-pyridyl)-1-butanol(NNAL),a metabolite of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone(NNK),was analyzed in the rat urine to assess the exposure of NNK in the tobacco smoke.The rats were exposed to environmental tobacco smoke.Urine samples were collected every month,all in two months.Quantitative analysis of was carried out by combined liquid chromatography-tandem mass spectrometry using a simple cleanup based on a molecularly imprinted polymer... |
| Keywords: | metabolite NNAL urine environmental tobacco smoke |
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