| 右旋肌醇甲醚唑类核苷类似物的合成 |
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| 引用本文： | 詹天荣,侯万国,徐洁.右旋肌醇甲醚唑类核苷类似物的合成[J].化学研究与应用,2009,21(8). |
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| 作者姓名： | 詹天荣 侯万国 徐洁 |
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| 作者单位： | 青岛科技大学化学与分子工程学院,山东,青岛,266042 |
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| 基金项目： | 山东省"泰山学者"基金，青岛科技大学博士科研启动基金 |
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| 摘 要： | 糖基部分中氧原子被亚甲基代替的碳环核苷是核苷类药物发展的一个重要方向.这类化合物表现出了比较宽的生物活性谱,特别是作为抗肿瘤1]和抗病毒2]药物的开发具有良好的前景.
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| 关 键 词： | 右旋肌醇甲醚 碳环唑类核苷 环氧开环反应 区域选择性 |
Synthesis of 3-O-methyl-D-chiro-inositol azole nucleosides analogus |
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| ZHAN Tian-rong,HOU Wan-guo,XU Jie.Synthesis of 3-O-methyl-D-chiro-inositol azole nucleosides analogus[J].Chemical Research and Application,2009,21(8). |
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| Authors: | ZHAN Tian-rong HOU Wan-guo XU Jie |
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| Institution: | College of Chemistry and Molecular Engineering;Qingdao University of Science and Technology;Qingdao 266042;China |
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| Abstract: | Using 3-O-methyl-D-chiro-inosito as starting material,through acetalation and mesylation the intermediate 3,which was subjected to hydrolysis to afford 3-O-Methyl-4-(methylsulfonyl)oxy]-D-chiro-inositol 4 was obtained.Subsequently,the key epoxide 5 was obtained in excellent yield via an epoxidation from the compound 4.Finally,the process of opening of epoxy ring by azole-bases resulted in the novel carbocyclic azole nucleoside compounds 6-10 in the presence of 1,8-diazabicycloundec-7-ene(DBU) as catalyst,w... |
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| Keywords: | 3-O-Methyl-D-chiro-inositol carbocyclic azole nucleoside opening of epoxy ring reaction regioselectivity |
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