| 高分子药物研究——ⅪⅤ.含核酸碱基和氮芥的聚磷酸酯的合成及其抗肿瘤活性初步研究 |
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| 引用本文： | 陈衢生,卓仁禧,周念恩.高分子药物研究——ⅪⅤ.含核酸碱基和氮芥的聚磷酸酯的合成及其抗肿瘤活性初步研究[J].高分子学报,1987,0(3):216-221. |
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| 作者姓名： | 陈衢生 卓仁禧 周念恩 |
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| 作者单位： | 武汉大学化学系 武汉
(陈衢生，卓仁禧)，武汉大学化学系 武汉(周念恩) |
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| 摘 要： | 本文通过缩聚反应,合成了十二种新的含5-氟尿嘧啶、尿嘧啶、胸腺嘧啶和氮芥的聚磷酸酯。部分聚合物抗动物肿瘤试验结果表明,既含氮芥又含5-氟尿嘧啶的聚磷酸酯具有较好的抗癌活性,对小鼠艾氏腹水癌的抑制率可达60％。初步研究了这类聚合物组成与抗肿瘤活性的关系。
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| 关 键 词： | 高分子药物 聚磷酸酯 抗肿瘤 5-氟尿嘧啶 氮芥 |
| 收稿时间： | 1985-02-07 |
CHEMOTHERAPEUTIC POLYMER ⅪⅤ.——Synthesis and Antitumor Activity of Polyphosphates Containing Both Nucleic Acid Bases and Nitrogen Mustard |
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| CHEN Qu-sheng,ZHUO Ren-xi,ZHOU Nian-en.CHEMOTHERAPEUTIC POLYMER ⅪⅤ.——Synthesis and Antitumor Activity of Polyphosphates Containing Both Nucleic Acid Bases and Nitrogen Mustard[J].Acta Polymerica Sinica,1987,0(3):216-221. |
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| Authors: | CHEN Qu-sheng ZHUO Ren-xi ZHOU Nian-en |
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| Institution: | Department of Chemistry; Wuhan University; Wuhan |
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| Abstract: | Twelve new polyphosphates were synthesized by reacting the monomers, i.e. N,N'-di(ω-hydroxyalkyl)-5-fluorouracil-1,3-diacetamide, N, N'-di(ω-hydroxyakyl)uracil-1,3-diacetamide, N, N'-di(ω-hydroxyalkyl) thymme-1,3-diacetamide, with bis-(2-chloroethyl) phosphoramidic di-chloride or ethyl dichlorophosphate. The antitumor activity of some of these polymers were tested against EAC, HSC and S18v in mine. The polyphosphates containing both 5-fluorouracil and nitrogen mustard exhibit higher antitumor activity. The inhibition ratio of polymer (IVb) against Ehrlish ascites reaches 60%. The relationship between the component of the polymers and the antitumor activity were also discussed. |
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| Keywords: | Polymeric druy Polyphosphate Antitumor 5-Fluorouracil Nitrogen mustard |
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