| 单手性臂脱氧胆酸分子裂缝的设计与微波合成 |
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| 引用本文： | 彭游,牟其明,杨祖幸,顿珠次仁,陈淑华.单手性臂脱氧胆酸分子裂缝的设计与微波合成[J].有机化学,2004,24(4):399-402. |
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| 作者姓名： | 彭游 牟其明 杨祖幸 顿珠次仁 陈淑华 |
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| 作者单位： | 四川大学化学学院,成都,610064 |
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| 基金项目： | 国家自然科学基金 (No.2 0 2 72 0 38)资助项目 |
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| 摘 要： | 以脱氧胆酸甲酯为隔离基 ,3位构建为非手性单元 ,在 12位引入手性单元 ,合成具有不同手性中心和裂穴的新型单手性臂分子裂缝受体 .结构均经1 HNMR ,IR ,MS及元素分析所确证 ,并且考察了其对中性小分子和D/L 氨基酸甲酯的识别性能 .初步研究表明 ,这类裂缝型受体不仅对中性小分子具有优良的识别性能 ,而且对D/L 氨基酸甲酯具有良好的手性识别能力 .
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| 关 键 词： | 脱氧胆酸 微波辐射 合成 分子裂缝 |
| 修稿时间： | 2003年6月30日 |
Design and Synthesis of Molecular Clefts with Only One Chiral Arm Derived from Cholic Acid under Microwave Irradiation |
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| PENG,You MU,Qi Ming YANG,Zu Xing DUNZHU,Ci Ren CHEN,Shu Hua.Design and Synthesis of Molecular Clefts with Only One Chiral Arm Derived from Cholic Acid under Microwave Irradiation[J].Chinese Journal of Organic Chemistry,2004,24(4):399-402. |
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| Authors: | PENG You MU Qi Ming YANG Zu Xing DUNZHU Ci Ren CHEN Shu Hua |
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| Abstract: | A novel type of molecular cleft with one chiral arm based on deoxycholic acid has been synthesized under microwave irradiation. The structures of these new receptors were characterized by 1H NMR, IR, MS spectra and elemental analysis. Their recognition properties for neutral small molecules and methyl esters of amino acids were investigated. The preliminary results indicate that these molecular clefts not only recognize neutral molecules, but also show good enantio selectivity for D/L amino acid methyl esters. |
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| Keywords: | deoxycholic acid microwave irradiation synthesis molecular cleft |
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