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| 手性环氧氯丙烷的制备及其药物应用 | |
| 引用本文： | 卢定强,涂清波,凌岫泉,王俊,李衍亮,党安旺,任伟,韦萍.手性环氧氯丙烷的制备及其药物应用[J].有机化学,2009,29(8):1209-1216. |
| 作者姓名： | 卢定强 涂清波 凌岫泉 王俊 李衍亮 党安旺 任伟 韦萍 |
| 作者单位： | 1. 南京工业大学药学院,南京,210009;江苏省药物研究所,南京,210009 2. 南京工业大学药学院,南京,210009 3. 南京工业大学生物与制药工程学院,南京,210009 |
| 基金项目： | 国家自然科学基金，国家重点基础研究发展计划 |
| 摘 要： | 手性环氧氯丙烷作为医药和化工等领域的重要中间体, 可以从廉价的外消旋体中分离得到, 具有广阔的市场前景. 综述了它的生物和化学法制备进展, 及其在药物合成方面的应用, 并展望了其制备工艺的发展趋势. |
| 关 键 词： | 手性 环氧氯丙烷 制备 药物 |
| 收稿时间： | 2009-2-5 |
| 修稿时间： | 2009-4-17 |
Preparation and Drug Application of Chiral Epichlorohydrin |
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| Lu Dingqiang,Tu Qingbo,Ling Xiuquan,Wang Jun,Li Yanliang,Dang Anwang,Ren Wei,Wei Ping.Preparation and Drug Application of Chiral Epichlorohydrin[J].Chinese Journal of Organic Chemistry,2009,29(8):1209-1216. | |
| Authors: | Lu Dingqiang Tu Qingbo Ling Xiuquan Wang Jun Li Yanliang Dang Anwang Ren Wei Wei Ping |
| Institution: | (a School of Pharmaceutical Sciences, Nanjing University of Technology, Nanjing 210009) (b Jiangsu Institute of Materia Medica, Nanjing 210009) (c College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009) |
| Abstract: | Chiral epichlorohydrin is an important intermediate in medicine and chemical industry fields, which has a wide market prospect and can be separated from racemate with low price. This review summarizes the progress in biological and chemical preparation of chiral epichlorohydrin and its application to drug synthesis. Furthermore, some promising research trends are proposed. |
| Keywords: | chiral epichlorohydrin preparation drug |
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