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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (08): 1209-1216. 上一篇    下一篇

综述与进展

手性环氧氯丙烷的制备及其药物应用

卢定强*,a,b; 涂清波a; 凌岫泉a ; 王 俊a ; 李衍亮a; 党安旺a; 任 伟c; 韦 萍c
  

  1. (a南京工业大学药学院 南京 210009)
    (b江苏省药物研究所 南京 210009)
    (c南京工业大学生物与制药工程学院 南京 210009)
  • 收稿日期:2009-02-05 修回日期:2009-04-17 发布日期:2009-08-30
  • 通讯作者: 卢定强

Preparation and Drug Application of Chiral Epichlorohydrin

Lu, Dingqiang*,a,b; Tu, Qingboa; Ling, Xiuquana; Wang, Juna; Li, Yanlianga ; Dang, Anwanga; Ren, Weic; Wei, Pingc
  

  1. (a School of Pharmaceutical Sciences, Nanjing University of Technology, Nanjing 210009) (b Jiangsu Institute of Materia Medica, Nanjing 210009)
    (c College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009)
  • Received:2009-02-05 Revised:2009-04-17 Published:2009-08-30
  • Contact: Lu, Dingqiang

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被引次数

16 | 1

手性环氧氯丙烷作为医药和化工等领域的重要中间体, 可以从廉价的外消旋体中分离得到, 具有广阔的市场前景. 综述了它的生物和化学法制备进展, 及其在药物合成方面的应用, 并展望了其制备工艺的发展趋势.

关键词: 手性, 环氧氯丙烷, 药物, 制备

Chiral epichlorohydrin is an important intermediate in medicine and chemical industry fields, which has a wide market prospect and can be separated from racemate with low price. This review summarizes the progress in biological and chemical preparation of chiral epichlorohydrin and its application to drug synthesis. Furthermore, some promising research trends are proposed.

Key words: preparation, drug, epichlorohydrin, chiral