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| L-乳酸齐聚物的制备及其三羰基铼衍生物的合成 | |
| 引用本文： | 朱华,黄立梁,张元庆,沈玉梅.L-乳酸齐聚物的制备及其三羰基铼衍生物的合成[J].有机化学,2011,31(1):87-95. |
| 作者姓名： | 朱华 黄立梁 张元庆 沈玉梅 |
| 作者单位： | 1. 中国科学院上海应用物理研究所,放射性药物研究中心,上海,201800;中国科学院研究生院,北京,100049 2. 中国科学院上海应用物理研究所,放射性药物研究中心,上海,201800 |
| 基金项目： | 中国科学院“百人计划”;国家自然科学基金 |
| 摘 要： | 以L-丙交酯为原料, 通过正交保护基对其羧基、羟基进行修饰, 合成并表征了乳酸3个系列的12个化合物. 同时以合成得到的乳酸六聚体为原料, 合成并表征了羟基封端的聚乳酸-聚乙二醇-三齿螯合剂系列化合物, 并将其与Et4N]2Re(CO)3Br3]配位合成了其冷标记三羰基铼配合物. 产物通过IR, 1H NMR, 13C NMR, ESI-HRMS, MALDI-HRMS或元素分析进行了表征. 该方法为扩展聚乳酸化学修饰法在材料科学中的应用奠定了基础. 此外分子量可控的乳酸-乙二醇结构铼配合物的设计合成扩展了其在分子影像科学的应用. |
| 关 键 词： | 乳酸 乙二醇 齐聚物 三羰基铼 合成 |
| 收稿时间： | 2010-03-02 |
| 修稿时间： | 2010-06-30 |
Synthesis of Molecularly Defined (L)-Lactic Acid Oligomers and Its Tricarbonyl Rhenium Derivatives |
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| Zhu Hua,Huang Liliang,Zhang Yuanqing,Shen Yumei.Synthesis of Molecularly Defined (L)-Lactic Acid Oligomers and Its Tricarbonyl Rhenium Derivatives[J].Chinese Journal of Organic Chemistry,2011,31(1):87-95. | |
| Authors: | Zhu Hua Huang Liliang Zhang Yuanqing Shen Yumei |
| Institution: | (Research Center of Radiopharmaceuticals, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800) (Graduate School of the Chinese Academy of Sciences, Beijing 100049) |
| Abstract: | Modification of the (L)-lactide hydroxyl and carboxylic acid groups was conducted by careful selection of orthogonal protective groups. Three series of lactide oligomers were synthesized for potential industrial production. Starting from Latide-Hexamer, synthesis of hydroxyl tailored biodegradable LA-PEG oligomers, and chelating to tricarbonyl rhenium(I) for medicinal applications were described. The structures of final products and the intermediates were confirmed by IR, 1H NMR, 13C NMR, HRMS, MALDI-HRMS or elemental analysis. The preparation of these lactide oligomers would have a wide range of applications in organic synthesis, molecular imaging and so on. |
| Keywords: | lactic acid ethylene glycol oligomer tricarbony rheniuml synthesis |
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