| 6-芳氧基-4-羟基-3-喹啉羧酸乙酯的合成及抗球虫活性的研究 |
| |
| 引用本文： | 邹燕,吴凯群,杨祖幸,WANG,Yu-Liang,侯太平,陈淑华.6-芳氧基-4-羟基-3-喹啉羧酸乙酯的合成及抗球虫活性的研究[J].有机化学,2007,27(8):981-984. |
| |
| 作者姓名： | 邹燕 吴凯群 杨祖幸 WANG Yu-Liang 侯太平 陈淑华 |
| |
| 作者单位： | 1. 四川大学化学学院,成都,610064
2. 四川大学生命科学学院,成都,610064 |
| |
| 基金项目： | 国家自然科学基金（No.20372052）资助项目. |
| |
| 摘 要： | 设计并合成了8个新的6-芳氧基-4-羟基-3-喹啉羧酸乙酯类化合物. 合成路线短, 产率高, 原料易得, 易实现工业化. 所有化合物的结构均经1H NMR, MS, IR和元素分析所证实. 并选择了其中3个化合物进行抗球虫活性实验, 结果表明. 化合物6-(2-甲氧苯氧基)-4-羟基-3-喹啉羧酸乙酯具有抗球虫效果, 并有可能作为抗球虫药物使用.
|
| 关 键 词： | 4-羟基-3-喹啉羧酸乙酯 合成 抗球虫活性 |
| 收稿时间： | 2006-10-8 |
| 修稿时间： | 2006-01-082007-01-23 |
Study on the Synthesis and Anticoccidial Activity of Ethyl 6-Aryloxy-4-hydroxy-3-quinolinecarboxylates |
| |
| ZOU,Yan,WU,Kai-Qun,YANG,Zu-Xing,WANG,Yu-Liang,HOU,Tai-Ping,CHEN,Shu-Hua.Study on the Synthesis and Anticoccidial Activity of Ethyl 6-Aryloxy-4-hydroxy-3-quinolinecarboxylates[J].Chinese Journal of Organic Chemistry,2007,27(8):981-984. |
| |
| Authors: | ZOU Yan WU Kai-Qun YANG Zu-Xing WANG Yu-Liang HOU Tai-Ping CHEN Shu-Hua |
| |
| Institution: | 1. College of Chemistry, Sichuan University, Chengdu 610064 2. College of Life Science, Sichuan University, Chengdu 610064 |
| |
| Abstract: | Eight ethyl 6-aryloxy-4-hydroxy-3-quinolinecarboxylates have been designed and synthesized. The new process is characterized by short synthetic route,high yield and cheap raw materials,which is con- venient for the commercial production.Structures of the new compounds have been confirmed by ~1H NMR, MS,IR spectra and elemental analysis.Three of the new compounds were chosen for the anticoccidial activ- ity test and the result had shown that ethyl 4-hydroxy-6-(2-methoxyphenoxy)-3-quinolinecarboxylate(4f) has anticoccidial activity and can be used as an anticoccidial medicine. |
| |
| Keywords: | ethyl 6-aryloxy-4-hydroxy-3-quinolinecarboxylate synthesis anticoccidial activity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《有机化学》浏览原始摘要信息 |
| 点击此处可从《有机化学》下载免费的PDF全文 |
|
