氢键作用驱动原花青素构筑水基抗菌黏合剂北大核心CSCD

水下黏合剂在生物医学和工程应用领域的需求越来越大。然而,目前报道的大多数水下黏合剂的制备方法中通常需要复杂的化学偶联或修饰,以及昂贵的构筑基元。本文利用低成本的葡萄籽提取物原花青素(PA)和商业化的聚乙二醇寡聚物(PEG)为构筑基元,发展了一种简单且经济的水下黏合剂的构筑策略,实现了在氢键作用下诱导仿生黏合剂生成。此黏合剂既可以在水上又可以在水下黏附不同材质的基底,且可重复使用。此外,易于制备的PA/PEG黏合剂也具有良好的抗菌活性和生物相容性。由于PA/PEG黏合剂具有制备简单、广谱黏附性、可循环使用和抗菌性等优点,将在医疗器械和制药应用中得到广泛应用。

Hydrogen Bond Interaction Driven Procyanidine Assembly into Underwater Adhesive with Antibacterial Activity

The demand of biomimetic underwater adhesives in biomedical and engineering applications is getting larger and larger. However， most of the reported preparation methods of biomimetic adhesives usually require complex chemical coupling or modification， and expensive constructing motifs. In this study， we develop a simple and economical construction strategy for the preparation of underwater adhesives using low-cost procyanidins （PA） extracted from grape seed and commercial polyethylene glycol oligomers （PEG） as building blocks， and realize the formation of biomimetic adhesives initiated by hydrogen bonding interaction. The adhesive can adhere to different substrates in both air and underwater， and can be reused at least three times. In addition， the PA/PEG adhesives are easy to prepare， have good antibacterial activity and biocompatibility. The PA/PEG adhesives could be widely used for pharmaceutical applications due to simple preparation， reusability， broad spectrum adhesion and antibacterial activity.