| 4-氨基吡啶催化6-烷氧基取代嘌呤衍生物的合成 |
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| 引用本文： | 陆鸿飞,武鼎铭,孙垒垒,高玉华.4-氨基吡啶催化6-烷氧基取代嘌呤衍生物的合成[J].应用化学,2012,29(4):402-409. |
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| 作者姓名： | 陆鸿飞 武鼎铭 孙垒垒 高玉华 |
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| 作者单位： | (江苏科技大学生物与化学工程学院 镇江 212003) |
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| 基金项目： | 江苏省自然科学基金(BK2009721);江苏科技大学青年骨干教师支持计划(37060902)资助项目 |
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| 摘 要： | 以6-氯嘌呤为底物,4-氨基吡啶为催化剂,甲醇为溶剂合成了6-烷氧基取代嘌呤化合物。当反应条件为n(6-氯嘌呤)∶n(4-氨基吡啶)∶n(三乙胺)=10∶1∶4,回流反应5～7 h时,6-烷氧基嘌呤化合物的收率大于85%。研究表明,体系中6-氯嘌呤、4-氨基吡啶和三乙胺的相对量对反应有很大影响,用4-氨基吡啶-三乙胺混合催化剂体系催化效果更好。
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| 关 键 词： | 氨基吡啶 嘌呤 催化 烷氧基化 合成 |
| 收稿时间： | 2011-06-14 |
Synthesis of O6-Substituted Purine Derivatives Catalyzed by 4-Amino-pyridine |
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| LU Hongfei
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WU Dingming
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SUN Leilei
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GAO Yuhua.Synthesis of O6-Substituted Purine Derivatives Catalyzed by 4-Amino-pyridine[J].Chinese Journal of Applied Chemistry,2012,29(4):402-409. |
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| Authors: | LU Hongfei WU Dingming SUN Leilei GAO Yuhua |
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| Institution: | (School of Biological and Chemical Engineering,Jiangsu University of ;
Science and Technology,Zhenjiang 212003,China) |
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| Abstract: | A series of O6-substituted purine derivatives was designed and prepared through an efficient and convenient method with 4-amino-pyridine as the catalyst in methanol solvent.Under optimized conditions: n(6-chloropurine)∶n(4-amino-pyridine)∶n(triethylamine)=10∶1∶4,refluxing for 5~7 h,the yield of 6-alkoxy purine was greater than 85%.Studies showed that,the relative amount of 6-chloropurine,4-amino-pyridine and triethylamine in the system had a great influence on the reaction,and the highest catalytic activity was achieved using a mixture of 4-amino-pyridine and triethylamine as the catalyst. |
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| Keywords: | amino-pyridines purine catalyst oxyalkylation synthesis |
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