| Au(Ⅰ)-Catalyzed 6-endo-dig Cyclizations of Aromatic 1,5-Enynes to 2-(Naphthalen-2-yl)anilines Leading to Divergent Syntheses of Benzo[α]carbazole,Benzo[c,h]cinnoline and Dibenzo[i]phenanthridine Derivatives |
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| 作者姓名： | Jiayue Fu Bingbing Li Xiugui Wang Qida Liang Xiaoshi Peng Lu Yang Tao Wan Xinxiu Wang Bin Lin Maosheng Cheng Yongxiang Liu |
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| 作者单位： | Key Laboratory of Structure-Based Drug Design and Discovery（Shenyang Pharmaceutical University）;Wuya College of Innovation;Institute of Drug Research in Medicine Capital of China;Liaoning Kangboshi Pharmaceutical Co. |
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| 基金项目： | the financial support of the National Natural Science Foundation of China(Grants 21977073);the Liao-ning BaiQianWan Talents Program;Liaoning Revitalization Tale nts Program;the program for the innoyative research team of the Ministry of Education;the program for the Liaoning innovative research team in university. |
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| 摘 要： | A gold(Ⅰ)-catalyzed 6-endo-dig cyclization of aromatic 1,5-enynes was developed to synthesize 2-(naphthalen-2-yl)anilines.The functional group tolerance of this cyclization was examined systematically and a possible mechanism was proposed.The derivatization of 2-(naphthalen-2-yl)aniline was carried out to facile access to benzoα]carbazole,benzoc,h]cinnoline and dibenzoi]phenanthridine derivatives in a divergent way.
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| 关 键 词： | Gold Homogeneous catalysis 6-endo-dig Cyclization Heterocycles Divergent synthesis |
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