Detection of magnetic nanoparticles with magnetoencephalography |
| |
Authors: | Wenyan Jia Guizhi Xu Robert J Sclabassi Jian-Gang Zhu Anto Bagic Mingui Sun |
| |
Institution: | 1. Department of Neurosurgery, University of Pittsburgh, Pittsburgh, PA 15260, USA;2. Department of Biomedical Engineering, Hebei University of Technology, Tianjin, 300130, P.R.China;3. Department of Electrical and Computer Engineering, Carnegie Melon University, Pittsburgh, PA 15213, USA;4. Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15260, USA |
| |
Abstract: | Superconducting quantum interference devices (SQUIDs) have been widely utilized in biomedical applications due to their extremely high sensitivity to magnetic signals. The present study explores the feasibility of a new type of nanotechnology-based imaging method using standard clinical magnetoencephalographic (MEG) systems equipped with SQUID sensors. Previous studies have shown that biological targets labeled with non-toxic, magnetized nanoparticles can be imaged by measuring the magnetic field generated by these particles. In this work, we demonstrate that (1) the magnetic signals from certain nanoparticles can be detected without magnetization using standard clinical MEG, (2) for some types of nanoparticles, only bound particles produce detectable signals, and (3) the magnetic field of particles several hours after magnetization is significantly stronger than that of un-magnetized particles. These findings hold promise in facilitating the potential application of magnetic nanoparticles to in vivo tumor imaging. The minimum amount of nanoparticles that produce detectable signals is predicted by theoretical modeling and computer simulation. |
| |
Keywords: | 85 25 Dq 75 75 +a 07 05 Tp |
本文献已被 ScienceDirect 等数据库收录! |
|