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Ferrofluids of magnetic multicore nanoparticles for biomedical applications |
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| Authors: | Silvio Dutz Joachim H Clement Thorsten Gelbrich Robert Müller Matthias Zeisberger |
| Institution: | a Institute of Photonic Technology, Albert-Einstein-Strasse 9, 07745 Jena, Germany b Department Internal Medicine II, University Clinic Jena, Erlanger Allee 101, 07740 Jena, Germany c Physikalisch-Technische Bundesanstalt, Abbestrasse 2-12, 10587 Berlin, Germany d Institute of Organic Chemistry and Macromolecular Chemistry, Heinrich Heine University, Universitätsstrasse 1, 40225 Düsseldorf, Germany |
| Abstract: | For a variety of magnetically based biomedical applications, it is advantageous to use sedimentation stable suspensions of relatively large (d>20 nm) magnetic core-shell nanoparticles. Water-based suspensions of multicore nanoparticles were prepared by coating of the particles (synthesized by means of a modified alkaline precipitation method) with a carboxymethyldextran shell. The resulting ferrofluids were structurally and magnetically characterized. It was found that these fluids show a specific heating power of about 60 W/g (f=400 kHz, H=10 kA/m). This value was increased up to 330 W/g by a simple fractionation method based on centrifugation. Finally, the cellular uptake of the multicore nanoparticles was demonstrated. |
| Keywords: | Cellular uptake Fractionation Hysteresis Magnetic loss Magnetic nanoparticle Magnetite Multicore particle Specific heating power |
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