| 离子对缔合物萃取分光光度法测定阿莫西林 |
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| 引用本文： | 段亚丽,杜黎明,陈彩萍.离子对缔合物萃取分光光度法测定阿莫西林[J].光谱学与光谱分析,2005,25(11):1865-1867. |
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| 作者姓名： | 段亚丽 杜黎明 陈彩萍 |
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| 作者单位： | 1.山西师范大学化学与材料科学学院，山西 临汾 041004
2.山西师范大学分析测试中心，山西 临汾 041004 |
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| 基金项目： | 山西省自然科学基金（20011016）资助课题 |
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| 摘 要： | 在弱酸性条件下，阿莫西林能与亚甲蓝(MB)反应生成易被1,2-二氯乙烷萃取的离子对缔合物，其最大吸收波长为λmax=657 nm。据此建立了测定阿莫西林的萃取分光光度法，药物浓度在0.4～6.8 mg·L-1范围内符合比尔定律，在最大吸收波长657 nm处表观摩尔吸光系数ε= 5.0×104 L·mol-1·cm-1，最低检出限为0.01 mg·L-1，回收率为97.5％～101.3％。实验表明该法可成功地用于药物制剂及尿样中阿莫西林含量的测定，结果令人满意。
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| 关 键 词： | 阿莫西林 亚甲蓝 萃取分光光度法 离子对缔合物 |
| 文章编号： | 1000-0593（2005）11-1865-03 |
| 收稿时间： | 2003-11-28 |
| 修稿时间： | 2004-04-20 |
Study on Extractive Spectrophotometry for Determination of Amoxicillin with Ionic Associate |
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| DUAN Ya-li,DU Li-ming,CHEN Cai-ping.Study on Extractive Spectrophotometry for Determination of Amoxicillin with Ionic Associate[J].Spectroscopy and Spectral Analysis,2005,25(11):1865-1867. |
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| Authors: | DUAN Ya-li DU Li-ming CHEN Cai-ping |
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| Institution: | 1. College of Chemistry and Material Science, Shanxi Normal University, Linfen 041004, China2. Center of Analysis and Testing, Shanxi Normal University, Linfen 041004, China |
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| Abstract: | A method of extractive spectrophotometry has been proposed for the determination of amoxicillin (AMO). The ion pairs complex of amoxicillin with methylene blue (MB) can be extracted into 1,2-dichloroethane at pH 3.3 and has absorption maximum at 657 nm. The ratio of amoxicillin to methylene blue in the ion pairs complex is 1:1. The apparent molar obsorptivity of ion pairs complex is 5.0 x 10(4) L x mol(-1) x cm(-1) at 657 nm. The calibration graph generated is linear over the range of 0.4-6.8 mg x L(-1) drug in solution with a correlation of 0.9989. The detection limit is 0.01 mg x L(-1) and the recovery of AMO is 97.5%-101.3%. The present method has been applied to the determination of amoxicillin in pharmaceutical formulations and urine samples with satisfactory results. |
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| Keywords: | Amoxicillin Methylene blue Extractive spectrophotometry Ionic associate |
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