| 一个镍(Ⅱ)配合物的合成、晶体结构及其与鲱鱼精DNA/BSA作用的光谱学研究 |
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| 引用本文： | 彭程佳,王克华,陆为学,管纯倩,胡雅静,马双,朱明昌,高恩君.一个镍(Ⅱ)配合物的合成、晶体结构及其与鲱鱼精DNA/BSA作用的光谱学研究[J].光谱学与光谱分析,2019,39(2):559-564. |
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| 作者姓名： | 彭程佳 王克华 陆为学 管纯倩 胡雅静 马双 朱明昌 高恩君 |
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| 作者单位： | 鞍山师范学院化学与生命科学学院,辽宁 鞍山,114007;沈阳化工大学配位化学研究室,辽宁 沈阳,110142 |
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| 基金项目： | 国家自然科学基金项目（21671138），鞍山市科技计划项目（2014MS15）和辽宁省大学生创新创业项目（201610169004）资助 |
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| 摘 要： | 合成了配合物Ni(2,2′-biby)(H2O)4]·(Htba)2·5H2O单晶，分子式中2,2′-biby为2,2′-联吡啶，H2tba为2-硫代巴比妥酸。通过红外光谱、元素分析和单晶X-射线衍射表征其结构，单晶X-射线衍射结果表明，该配合物单晶属于正交晶系，Pbca 空间群，晶胞参数为a=13.662(2) Å，b=19.470(4)Å，c=21.590(4) Å。应用紫外光谱和荧光光谱研究了其与鲱鱼精DNA/牛血清白蛋白(BSA)的相互作用，研究结果表明，标题化合物与DNA为静电结合，对牛血清白蛋白发生静态猝灭作用。
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| 关 键 词： | 配合物 DNA作用 BSA作用 晶体结构 |
| 收稿时间： | 2017-10-25 |
Synthesis,Crystal Structure and DNA/BSA Interaction of a Ni(Ⅱ) Coordination Compound |
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| PENG Chen-jia,WANG Ke-hua,LU Wei-xue,GUAN Chun-qian,HU Ya-jing,MA Shuang,ZHU Ming-chang,GAO En-jun.Synthesis,Crystal Structure and DNA/BSA Interaction of a Ni(Ⅱ) Coordination Compound[J].Spectroscopy and Spectral Analysis,2019,39(2):559-564. |
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| Authors: | PENG Chen-jia WANG Ke-hua LU Wei-xue GUAN Chun-qian HU Ya-jing MA Shuang ZHU Ming-chang GAO En-jun |
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| Institution: | 1. School of Chemistry and Life Science, Anshan Normal University, Anshan 114007, China
2. Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang 110142, China |
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| Abstract: | A Ni(Ⅱ) coordination complex Ni(2,2′-biby) (H2O)4]·(tba)2·5H2O(2,2′-biby=2,2′-dipyridine, H2tba=2-thiobarbituric acid ) has been synthesized and structurally characterized by IR, element analysis and single crystal X-ray diffractometry. The results of single crystal X-ray diffractometry displayed that the title compound belongs to orthorhombic with space group of Pbca, and its cell parameters are a=13.662(2)Å，b=19.470(4)Å，c=21.590(4)Å. The binding of title compound with Herring sperm DNA/BSA has been investigated by absorption and fluorescence spectra, and the results displayed that the title compound binds with DNA in electrostatic interaction mode, and quenches the intrinsic fluorescence of BSA by a static quenching mechanism. |
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| Keywords: | Coordination complexes DNA binding BSA binding Crystal structure |
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