| 一个A环开环型芳基萘内酯类木脂素2D NMR全归属 |
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| 引用本文： | 孙彦君,关延彬,陈虹,赵璇,华会明.一个A环开环型芳基萘内酯类木脂素2D NMR全归属[J].波谱学杂志,2013,30(3):380-386. |
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| 作者姓名： | 孙彦君 关延彬 陈虹 赵璇 华会明 |
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| 作者单位： | 河南中医学院药学院,河南郑州450046;沈阳药科大学,基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016;河南中医学院药学院,河南郑州,450046;武警医学院生药教研室,天津,300162;沈阳药科大学,基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016 |
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| 基金项目： | Doctoral Science Foundation of Henan University of Traditional Chinese Medicine (BSJJ2011-13), the National Natural Science Foundation of China (30873363). |
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| 摘 要： | 采用二维核磁共振技术(1H-1H COSY, DEPT, HSQC, HMBC, NOESY)和CD光谱，确定了A环开环型芳基萘内酯类木脂素3′, 4′-O, O-demethylene-4-O- demethylpodophyllotoxin (1)的结构. 首次对化合物1的13C NMR数据进行了全归属.
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| 关 键 词： | NMR 归属 2D NMR CD 芳基萘内酯类木脂素 |
| 收稿时间： | 2012-11-07 |
NMR Assignments of A Ring A-seco Aryltetralin Lignan |
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| SUN Yan-jun
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GUAN Yan-bin
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CHEN Hong
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ZHAO Xuan
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HUA Hui-ming.NMR Assignments of A Ring A-seco Aryltetralin Lignan[J].Chinese Journal of Magnetic Resonance,2013,30(3):380-386. |
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| Authors: | SUN Yan-jun GUAN Yan-bin CHEN Hong ZHAO Xuan HUA Hui-ming |
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| Institution: | 1. School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China;;
2. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;;
3. Pharmacognosy Division, Medical College of Chinese People's Armed Police Force, Tianjin 300162, China |
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| Abstract: | The 13C and 1H NMR chemical shifts of a ring A-seco aryltetralin lignan, 3′,4′-O, O-demethylene-4-O-demethylpodophyllotoxin, were assigned based on 1D and 2D NMR data, including 1H-1H COSY, DEPT, HMBC, and HSQC. Stereochemistry was established based on 1H coupling constants (J- values), NOESY results and circular dichroism (CD) results. The 13C NMR signals of the compound was completely assigned for the first time. |
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| Keywords: | NMR assignment 2D NMR circular dichroism aryltetralin lignans |
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