| 一个含苯并咪唑环的酰氨基硫脲NMR研究 |
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| 引用本文： | 李英俊,邱文龙,许永廷,罗潼川,于洋,邵昕.一个含苯并咪唑环的酰氨基硫脲NMR研究[J].波谱学杂志,2013,30(1):131-139. |
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| 作者姓名： | 李英俊 邱文龙 许永廷 罗潼川 于洋 邵昕 |
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| 作者单位： | 辽宁师范大学 化学化工学院，辽宁 大连 116029 |
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| 基金项目： | Natural Science Foundation of Liaoning Province(20102126) |
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| 摘 要： | 该文合成了一个新的在医药方面具有潜在应用价值的含苯并咪唑环的酰氨基硫脲化合物，即4-(4-甲氧基苯基)-1-2-(4-硝基苯氧基甲基)-苯并咪唑-1-基\]甲酰基氨基硫脲，并利用元素分析、IR和NMR对其结构进行了表征. 通过NOESY谱确定了其两种异构体(A和B)的构型，并利用2D NMR技术对它们的1H NMR 和13C NMR谱进行了全归属，给出了相应的偶合常数和两种异构体的含量.
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| 关 键 词： | 核磁共振(NMR) 归属 2D NMR 4-(4-甲氧基苯基)-1-[2-(4-硝基苯氧基甲基)-苯并咪唑-1-基]甲酰基氨基硫脲 构型分析 |
| 收稿时间： | 2012-06-08 |
An NMR Study on An Acylthiosemicarbazide Containing Benzimidazole Moiety |
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| LI Ying-jun,QIU Wen-long,XU Yong-ting,LUO Tong-chuan, YU Yang,SHAO Xin.An NMR Study on An Acylthiosemicarbazide Containing Benzimidazole Moiety[J].Chinese Journal of Magnetic Resonance,2013,30(1):131-139. |
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| Authors: | LI Ying-jun QIU Wen-long XU Yong-ting LUO Tong-chuan YU Yang SHAO Xin |
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| Institution: | College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China |
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| Abstract: | A novel compound with potential pharmaceutical applications, 4-(4-methoxyphenyl)-1-{2-(4-nitrophenoxymethyl)-benzimidazol-1-yl]methyl} carbonylthiosemicarbazide (1) was synthesized. Its structure was determined by elemental analysis, IR and NMR techniques. The existence of two isomers of compound 1 were confirmed by NOESY spectroscopy. The 1H and 13C NMR signals of the isomers were assigned completely using 2D NMR techniques, and the corresponding coupling constants and the tautomeric ratios of isomers were also reported. |
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| Keywords: | NMR assignment 2D NMR 4-(4-methoxyphenyl)-1-{[2-(4-nitrophenoxymethyl)-benzimidazol-1-yl]methyl}-carbonylthiosemicarbazide conformational analysis |
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