| 苯基哌嗪衍生物的NMR波谱研究 |
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| 引用本文： | 肖志会,袁牧,黄建设,吴军.苯基哌嗪衍生物的NMR波谱研究[J].波谱学杂志,2004,21(3):365-369. |
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| 作者姓名： | 肖志会 袁牧 黄建设 吴军 |
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| 作者单位： | 中国科学院南海海洋研究所,广东省海洋药物重点实验室,广东,广州,510301;中国科学院天然产物化学重点实验室,贵州,贵阳,550002 |
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| 摘 要： | 通过1H NMR、13C NMR、及HMBC、HSQC、1H-1H DQFCOSY等2D NMR方法对新合成的10个苯基哌嗪衍生物类抗高血压药物进行结构鉴定， 并对这些化合物的1H NMR和13C NMR信号进行了全归属. 初步探讨了取代基对分子13C化学位移的影响.
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| 关 键 词： | 核磁共振 归属 化学位移 苯基哌嗪 |
| 文章编号： | 1000-4556(2004)03-0365-05 |
| 收稿时间： | 2004-02-19 |
| 修稿时间： | 2004年2月19日 |
A NMR STUDY OF PHENYLPIPERAZINE DERIVATIVES |
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| XIAO Zhi-hui,YUAN Mu,HUANG Jian-she,WU Jun Guangdong Key Laboratory of Marine Materia Medica,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou ,China The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences,Guiyang ,China.A NMR STUDY OF PHENYLPIPERAZINE DERIVATIVES[J].Chinese Journal of Magnetic Resonance,2004,21(3):365-369. |
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| Authors: | XIAO Zhi-hui YUAN Mu HUANG Jian-she WU Jun Guangdong Key Laboratory of Marine Materia Medica South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou China The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences Guiyang China |
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| Institution: | 1.Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301,China; 2.The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002,China |
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| Abstract: | Having the potential of being used as α1-adrenoceptor antagonist and new antihypertensive drugs, ten phenylpiperazine derivatives were synthesized, and their structures were determined by 1H NMR, 13C NMR, HMBC, HSQC and 1H-1H DQF-COSY. The 1H and 13C chemical shifts of these compounds were assigned. The relationship between the substitute groups and the 13C chemical shifts was discussed. |
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| Keywords: | NMR assignments chemical shift phenylpiperazine |
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