| 6-硝基-7-二异丙基香豆素磷酸酯的结构确定 |
| |
| 引用本文： | 陈晓岚,徐少华,屈凌波,袁金伟,李锡勇,王俊亮,李会娜.6-硝基-7-二异丙基香豆素磷酸酯的结构确定[J].波谱学杂志,2010,27(4):635-641. |
| |
| 作者姓名： | 陈晓岚 徐少华 屈凌波 袁金伟 李锡勇 王俊亮 李会娜 |
| |
| 作者单位： | 郑州大学,化学系,河南省化学生物学与有机化学重点实验室,河南,郑州,450052;郑州大学,化学系,河南省化学生物学与有机化学重点实验室,河南,郑州,450052;河南工业大学,化学化工学院,河南,郑州,450051;河南工业大学,化学化工学院,河南,郑州,450051 |
| |
| 基金项目： | 国家自然科学基金，河南省科技创新杰出人才计划资助项目 |
| |
| 摘 要： | 以7-羟基香豆素为原料,与硝酸在乙醇中反应得到了其硝化产物,发现硝化后的香豆素不能通过传统的Atherton-Todd反应实现磷酰化,通过改进反应条件即加入少量碳酸钾,顺利得到其相应的磷酰化产物.利用核磁共振(NMR)技术,确认得到的磷酰化产物是6-硝基-7-二异丙基香豆素磷酸酯.通过2D NMR对目标化合物的1H和13C NMR数据进行了全归属和较详细的解析,其结构进一步被X-ray晶体结构所证实.
|
| 关 键 词： | 核磁共振(NMR) 归属 2D NMR X-ray 6-硝基-7-二异丙基香豆素磷酸酯 |
| 收稿时间： | 2009-11-06 |
Spectroscopic Characterization of 6-Nitryl-7-diisopropyl Coumarin Phosphate |
| |
| CHEN Xiao-lan,XU Shao-hua,QU Ling-bo,YUAN Jin-wei,LI Xi-yong,WANG Jun-liang,LI Hui-na.Spectroscopic Characterization of 6-Nitryl-7-diisopropyl Coumarin Phosphate[J].Chinese Journal of Magnetic Resonance,2010,27(4):635-641. |
| |
| Authors: | CHEN Xiao-lan XU Shao-hua QU Ling-bo YUAN Jin-wei LI Xi-yong WANG Jun-liang LI Hui-na |
| |
| Institution: | 1. Key Laboratory of Chemical Biology and Organic Chemistry, Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China;;
2. School of Chemistry & Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China |
| |
| Abstract: | In this study, 7-hydroxycoumarin was nitrified using nitric acid in ethanol solvent to obtain 6-nitro-7-hydroxycoumarin. Phosphorylation of 6 nitro-7-hydroxycoumarin, however, could not be realized using the traditional Atheron-Todd reaction. By adding a little potassium carbonate into the reaction vessel, the phosphorylation reaction occurred successfully. Complete assignment of the 1H and 13C NMR chemical shifts of phosphorylated 6-nitro-7-hydroxycoumarin was achieved with 2D NMR techniques, including DEPT, 1H-1H COSY, HSQC and HMBC. The structure of the compound was also elucidated by X-ray crystallography. |
| |
| Keywords: | NMR assignment 2D NMR X-ray crystallography 6-nitryl-7-diisopropyl coumarin phosphate |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《波谱学杂志》浏览原始摘要信息 |
| 点击此处可从《波谱学杂志》下载免费的PDF全文 |
|
